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1.
Childs Nerv Syst ; 38(7): 1377-1380, 2022 07.
Artículo en Inglés | MEDLINE | ID: mdl-34595587

RESUMEN

INTRODUCTION: Central nervous system xanthogranulomas are uncommon clinical entities, and symptomatic bilateral choroid plexus xanthogranulomas are rare. CASE PRESENTATION: We present the case of a 15-year-old male patient with bilateral choroid plexus xanthogranulomas with symptoms of increased intracranial pressure. Gross total resection of the tumor in the left lateral ventricle was performed. The patient improved, and asymptomatic right-sided tumor was monitored at follow-up. CONCLUSION: The main treatment objective in these tumors is gross total resection. Asymptomatic tumors can be followed without intervention. However, surgery should be performed for symptomatic tumors that cause hydrocephalus or symptoms of increased intracranial pressure.


Asunto(s)
Neoplasias del Plexo Coroideo , Hidrocefalia , Hipertensión Intracraneal , Xantomatosis , Adolescente , Niño , Plexo Coroideo/diagnóstico por imagen , Plexo Coroideo/patología , Plexo Coroideo/cirugía , Neoplasias del Plexo Coroideo/diagnóstico por imagen , Neoplasias del Plexo Coroideo/patología , Neoplasias del Plexo Coroideo/cirugía , Granuloma/diagnóstico por imagen , Granuloma/patología , Granuloma/cirugía , Humanos , Hidrocefalia/diagnóstico por imagen , Hidrocefalia/etiología , Hidrocefalia/cirugía , Hipertensión Intracraneal/patología , Ventrículos Laterales/patología , Masculino , Xantomatosis/complicaciones , Xantomatosis/diagnóstico por imagen , Xantomatosis/cirugía
2.
Gen Physiol Biophys ; 40(4): 341-350, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-34350838

RESUMEN

In this study, the effect of high-calorie feeding and aerobic exercise on skeletal and cardiac muscle citrate synthase (CS), carnitine palmitoyltransferase-I (CPT-I), and -II (CPT-II) mRNA expressions were evaluated. Genetically non-obese rats were grouped as normal-high calorie and sedentary-exercising. Gastrocnemius-soleus and heart muscles' CS, CPT-I, and CPT-II expressions and skeletal muscles' histopathological characteristics were evaluated. High-fat diet had increased body weight by 10% and aerobic exercise did not make any difference. Skeletal muscle CS expression was increased significantly in normal-calorie exercising group. Exercise and high-fat diet did not change CPT-I and CPT-II expressions in both heart and skeletal muscle. Histopathological evaluations demonstrated increased cytoplasmic lipid droplets in high-calorie fed sedentary rats, and exercise had reduced lipid droplets in skeletal muscle. Also, both mitochondria and nuclei distribution were impaired in high-calorie groups. In conclusion, aerobic exercise without food restriction was not enough to make significant changes in fat transportation mechanism into skeletal and heart muscle.


Asunto(s)
Carnitina O-Palmitoiltransferasa , Músculo Esquelético , Animales , Carnitina O-Palmitoiltransferasa/genética , Citrato (si)-Sintasa , Miocardio , ARN Mensajero/genética , Ratas
3.
J Reconstr Microsurg ; 31(3): 191-7, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25423028

RESUMEN

BACKGROUND: Complete nerve regeneration and clinical healing remain a challenge despite considerable advances in the treatment of peripheral nerve injuries. To improve nerve regeneration, several experimental molecular procedures have been attempted. This study aimed to investigate the effects of folic acid on peripheral nerve healing after transection and end-to-end suture repair of the tibial nerve in rats. METHODS: In this study, 20 adult male Wistar Albino rats weighing 225 to 250 g were used. The right tibial nerves of 20 rats were explored, transected, and sutured using the end-to-end technique. The rats were randomly allocated to either the intraperitoneally administered folic acid group (test group) or the control group. Preoperative and 6-week postoperative neurophysiological studies were performed by the same researcher. Myelin-sheathed axons were counted. RESULTS: The results demonstrated that the folic acid-treated group exhibited improved electromyographic results compared with the control group. Histological evaluation revealed that the axons were well preserved and that the axon quantity and density were increased in the test group compared with the control group. Quantitative results also increased in the test group compared with the control group (p = 0.001). CONCLUSION: In this study, 6-week intraperitoneal administration of 80 µg/kg of folic acid significantly improved peripheral nerve healing. Histological analysis of the group that received folic acid revealed increased axon myelination with little granular tissue or fibrosis. We propose that folic acid supplementation may be an effective component of peripheral nerve injury treatment.


Asunto(s)
Ácido Fólico/administración & dosificación , Nervio Tibial/cirugía , Cicatrización de Heridas/efectos de los fármacos , Animales , Electromiografía , Masculino , Regeneración Nerviosa/fisiología , Distribución Aleatoria , Ratas Wistar , Nervio Tibial/lesiones , Cicatrización de Heridas/fisiología
4.
Turk J Haematol ; 30(4): 413-5, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24385834

RESUMEN

UNLABELLED: Sweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory nodules or papules that occur in association with infection, malignancy, connective tissue disease, or following exposure to certain drugs. Here, we present Sweet syndrome in a case with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) which is a relatively rare co-occurrence. CONFLICT OF INTEREST: None declared.

5.
Rev Assoc Med Bras (1992) ; 69(1): 153-158, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36820722

RESUMEN

OBJECTIVE: Breast cancer is the most common malignancy in women. In the treatment of these patients, pathological complete response is defined as the absence of invasive cancer in breast or lymph node tissue after the completion of neoadjuvant chemotherapy. In this study, we aimed to investigate the relationship of enhancer of zeste homolog 2 and mucin 1 expressions with pathological complete response in patients with breast cancer receiving neoadjuvant chemotherapy. METHODS: A total of 151 patients were included in the study. Enhancer of zeste homolog 2 and mucin 1 expressions were evaluated in the biopsy materials pre-neoadjuvant chemotherapy and post-neoadjuvant chemotherapy surgical material, and their relationship with pathological complete response was investigated. RESULTS: The pathological complete response rates were significantly higher among the hormone receptor-negative patients, those with a high Ki-67 score, and patients with HER2-positive. Higher pathological complete response rates were obtained from patients with enhancer of zeste homolog 2 expression positivity pre-neoadjuvant chemotherapy. In addition, after neoadjuvant chemotherapy, enhancer of zeste homolog 2 expression was found to be completely negative in materials with pathological complete response; that is, in breast tissues considered to be tumor-free. While there was no significant relationship between mucin 1 expression and pathological complete response pre-neoadjuvant chemotherapy, mucin 1 expression was determined to significantly differ between the tissues with and without pathological complete response among the surgical materials examined. CONCLUSION: In our study investigating the relationship between enhancer of zeste homolog 2 and mucin 1 expression and pathological complete response in patients who received neoadjuvant chemotherapy, we found that enhancer of zeste homolog 2 expression could be used as a predictive marker for pathological complete response. However, mucin 1 expression was not associated with pathological complete response.


Asunto(s)
Neoplasias de la Mama , Proteína Potenciadora del Homólogo Zeste 2 , Mucina-1 , Femenino , Humanos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/genética , Proteína Potenciadora del Homólogo Zeste 2/genética , Mucina-1/genética , Estadificación de Neoplasias , Receptor ErbB-2/metabolismo
6.
Curr Med Imaging ; 17(2): 310-317, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33357196

RESUMEN

BACKGROUND: Silent pituitary adenomas are clinically non-functional (i.e., without clinically evident pituitary hormone production). INTRODUCTION: The aim of this study was to investigate subjects with silent pituitary adenomas for possible variations in their clinical status. METHODS: A total of 102 patients who had undergone surgery for pituitary adenoma and had been diagnosed with silent pituitary adenoma was included in the study. The patients' preoperative and postoperative hormonal parameters and magnetic resonance imaging (MRI) features were collected, and pathological specimens were re-evaluated. RESULTS: Immunohistochemistry results of the 102 patients were as follows: hormone-negative adenomas (n=35) 35.5%; FSH+LH-positivity (n=32) 31.3%; ACTH-positivity (n=11) 10.7%; α-subunit- positivity (n= 9) 8.8%; prolactin-positivity (n=8) 7.8%; GH-positivity (n=6) 5.4%; and plurihormonal adenoma (n=1). The mean sizes of SGA, SGHA, and SCA were 28.0±12.7, 30.0±16.0, and 27.7±8.9mm (p>0.05), respectively. With the exception of silent gonadotroph adenomas (SGAs), female gender dominance was shown in patients with silent growth hormone adenoma (SGHA) and silent corticotroph adenoma (SCA). Although no clinical relevance was observed in relation to hormonal excess, preoperative GH (4.21±4.6, vs. 0.27±0.36 p=0.00) was slightly more elevated in SGHA than in GH-negative adenomas. Additionally, preoperative basal ACTH values (47.3±28.7 vs. 23.9±14.4, p=0.003) were also higher in SCA compared to the other types. Our findings revealed SCAs to be of more aggressive behaviour than SGHAs and SGAs due to invasiveness in radiological imaging, their elevated re-operation, and postoperative ACTH values. CONCLUSION: Silent pituitary adenomas represent a challenging diagnostic tumour group. Careful initial evaluation of patients with pituitary adenomas should consider any mild signs and symptoms of functionality, particularly in cases of GH- and ACTH-secreting adenomas.


Asunto(s)
Adenoma Hipofisario Secretor de ACTH , Adenoma , Neoplasias Hipofisarias , Adenoma/cirugía , Femenino , Humanos , Inmunohistoquímica , Imagen por Resonancia Magnética , Neoplasias Hipofisarias/cirugía
7.
J BUON ; 25(1): 159-167, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32277627

RESUMEN

PURPOSE: Twenty percent of the breast cancers are triple negative (TNBC). Despite the impressive progression in the biology of this subgroup, data is limited as compared to hormone and/or HER2 positive cases. Thus, the aim of this study was to detect the expression levels and to identify the prognostic values of MUC1, EGFR and PD-L1 in TNBC. METHODS: MUC1, EGFR and PD-L1 expressions were detected by immunohistochemistry in 97 cases with TNBC. Associations between clinical and histopathological parameters with overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method and compared by the log-rank test. Prognostic effects were analyzed by Cox proportional hazard models. RESULTS: During a median follow-up of 93 months (0.6-168.7) the mean PFS was 110.1 and OS was 121.8 months. Tumor diameter (T), involved lymph node status (N) and TNM were found to be prognostic for PFS and OS. PD-L1 in microenvironment (PD-L1 ME) and EGFR expression were found to be associated with longer PFS and OS, but MUC1 and tumor PD-L1 (PD-L1 TM) expressions were not. All combined analyses showed that in the subgroups of MUC1, PD-L1 TM or ME positive, EGFR expression was correlated with longer PFS and OS than those who were not. Older age (≥70 years), T and N status and also EGFR expression were found to be independent prognostic factors for OS in Cox regression analysis. CONCLUSION: EGFR expression was found to be one of the most important prognostic factors in addition to T and N status in cases with TNBC.


Asunto(s)
Antígeno B7-H1/biosíntesis , Mucina-1/biosíntesis , Neoplasias de la Mama Triple Negativas/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Antígeno B7-H1/genética , Antígeno B7-H1/metabolismo , Receptores ErbB/biosíntesis , Receptores ErbB/genética , Receptores ErbB/metabolismo , Femenino , Humanos , Persona de Mediana Edad , Mucina-1/genética , Mucina-1/metabolismo , Pronóstico , Estudios Prospectivos , Neoplasias de la Mama Triple Negativas/genética , Neoplasias de la Mama Triple Negativas/patología , Adulto Joven
9.
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(1): 153-158, Jan. 2023. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1422597

RESUMEN

SUMMARY OBJECTIVE: Breast cancer is the most common malignancy in women. In the treatment of these patients, pathological complete response is defined as the absence of invasive cancer in breast or lymph node tissue after the completion of neoadjuvant chemotherapy. In this study, we aimed to investigate the relationship of enhancer of zeste homolog 2 and mucin 1 expressions with pathological complete response in patients with breast cancer receiving neoadjuvant chemotherapy. METHODS: A total of 151 patients were included in the study. Enhancer of zeste homolog 2 and mucin 1 expressions were evaluated in the biopsy materials pre-neoadjuvant chemotherapy and post-neoadjuvant chemotherapy surgical material, and their relationship with pathological complete response was investigated. RESULTS: The pathological complete response rates were significantly higher among the hormone receptor-negative patients, those with a high Ki-67 score, and patients with HER2-positive. Higher pathological complete response rates were obtained from patients with enhancer of zeste homolog 2 expression positivity pre-neoadjuvant chemotherapy. In addition, after neoadjuvant chemotherapy, enhancer of zeste homolog 2 expression was found to be completely negative in materials with pathological complete response; that is, in breast tissues considered to be tumor-free. While there was no significant relationship between mucin 1 expression and pathological complete response pre-neoadjuvant chemotherapy, mucin 1 expression was determined to significantly differ between the tissues with and without pathological complete response among the surgical materials examined. CONCLUSION: In our study investigating the relationship between enhancer of zeste homolog 2 and mucin 1 expression and pathological complete response in patients who received neoadjuvant chemotherapy, we found that enhancer of zeste homolog 2 expression could be used as a predictive marker for pathological complete response. However, mucin 1 expression was not associated with pathological complete response.

10.
Acta Orthop Traumatol Turc ; 41(2): 140-6, 2007.
Artículo en Turco | MEDLINE | ID: mdl-17483651

RESUMEN

OBJECTIVES: We investigated the effect of human placental suspension (HPS) on rat sciatic nerve regeneration. METHODS: Eight adult female Sprague-Dawley rats weighing between 250 and 300 g were randomly divided into control and study groups equal in number. Both sciatic nerves were explored under anesthesia, transsected and then immediately repaired. At the end of the operation, and on the second and fifth days, HPS and saline were administered to the operation zone in the test and control groups, respectively. For functional examination, electromyographic activity was measured in posterior extremities of all rats preoperatively and at the end of eight weeks. The rats were then sacrificed to obtain transections from the repaired area and its distal region for histologic examination and the number of myelin-sheathed axons was estimated in both regions. RESULTS: Electromyographic study showed delayed latency and decreased amplitude following operation in both groups, being less severe in the study group without reaching a significant difference from the control group (p>0.05). The most notable histopathologic finding was increased endoneural collagen in the control group and regenerative axonal growth in the HPS group. The number of axons was greater in the distal region in both groups. In both regions, the number of myelin-sheathed axons was greater in the HPS group, but this difference was significant only for the number of axons in the repair zone (p=0.001). CONCLUSION: Our data suggest that HPS may exert a favorable effect on peripheral nerve regeneration.


Asunto(s)
Regeneración Nerviosa/fisiología , Extractos Placentarios/farmacología , Nervio Ciático/lesiones , Nervio Ciático/cirugía , Animales , Modelos Animales de Enfermedad , Femenino , Inyecciones , Regeneración Nerviosa/efectos de los fármacos , Extractos Placentarios/administración & dosificación , Ratas , Ratas Sprague-Dawley
11.
Neuromuscul Disord ; 27(9): 836-842, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28624463

RESUMEN

Centronuclear myopathies (CNM) are a clinically and genetically heterogeneous group of congenital myopathies, defined histologically by increased number of fibres with centrally located nuclei, and type I fibre predominance in muscle biopsy. Myotubular myopathy, the X-linked form of CNM caused by mutations in the phosphoinositide phosphatase MTM1, is histologically characteristic since muscle fibres resemble myotubes. Here we present two unrelated patients with CNM and typical myotubular fibres in the muscle biopsy caused by mutations in striated muscle preferentially expressed protein kinase (SPEG). Next generation sequencing revealed novel biallelic homozygous mutations in SPEG in both cases. Patient 1 showed the c.1627_1628insA (p.Thr544Aspfs*48) mutation and patient 2 the c.9586C>T (p.Arg3196*) mutation. The clinical phenotype was distinctive in the two patients since patient 2 developed a dilated cardiomyopathy with milder myopathy features, while patient 1 showed only myopathic features without cardiac involvement. These findings expand the genotype-phenotype correlations after the initial report. Additionally, we describe whole body muscle MRI of patient 2 and we argue on the different SPEG isoforms in skeletal muscle and heart as the possible explanation leading to variable phenotypes of SPEG mutations.


Asunto(s)
Estudios de Asociación Genética , Proteínas Musculares/genética , Mutación/genética , Miopatías Estructurales Congénitas/etiología , Miopatías Estructurales Congénitas/genética , Proteínas Serina-Treonina Quinasas/genética , Niño , Preescolar , Humanos , Imagen por Resonancia Magnética , Masculino , Músculo Esquelético/diagnóstico por imagen , Músculo Esquelético/fisiopatología , Miopatías Estructurales Congénitas/diagnóstico por imagen , Miopatías Estructurales Congénitas/patología , Fenotipo
12.
Leuk Lymphoma ; 47(12): 2527-41, 2006 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-17169797

RESUMEN

Thirty-two cases of granulocytic sarcoma (GS) are reported in this paper. Age range was from 16 - 70 years. GS was accompanied by AML in 13 cases, ALL (My+) in one case, CML in 11 cases and MDS in two cases. GS was diagnosed simultaneously with leukemia in five cases and preceded the leukemia in eight. Lymph node and soft tissue were the most commonly detected localizations. Seven cases had first been diagnosed as NHL. Histopathologically blastic, immature and mature variants were found in 11, nine and 11 cases respectively and overall survival was shortest in the blastic type. Myeloperoxidase and lysozyme were found to be positive in 30 and 24 cases respectively. Therapy was radiation in five cases and surgery in three. Systemic chemotherapy was given to the cases. The clinical outcome of the patients after the diagnosis of GS was poor. GS is a unique entity; prognosis is poor but it is important to detect the signaling pathways associated with migration of myeloid cells to the extra-medullary tissues. The critical factors for detecting this interesting tumor are to be aware of this disease, cooperation between clinician and pathologist and the application of special stains to detect the myeloid origin.


Asunto(s)
Sarcoma Mieloide/diagnóstico , Adolescente , Adulto , Anciano , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Leucemia Linfocítica Crónica de Células B/terapia , Linfoma no Hodgkin/terapia , Masculino , Oncología Médica/métodos , Persona de Mediana Edad , Trasplante de Células Madre , Resultado del Tratamiento
13.
Adv Ther ; 23(1): 23-32, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16644604

RESUMEN

This story investigated the effects of interferon-alpha-2b (IFN-alpha2b) on the optic nerves of 17 adult male Wistar albino rats. Animals were divided into 3 groups: 6 rats (group 1) received 7.5 units (5 mIU/m2) IFN-alpha2b-a normal treatment dose, and 6 (groups 2) received 30.0 units (20 mIU/m2)-a high dose; 5 rats (control group) received 0.5 mL saline. Test substances were delivered by intraperitoneal injection 3 times a week for 3 weeks with animals under inhalation anesthesia. After the rats were sacrificed, their optic nerves were dissected, sectioned, and examined under an electron microscope. The mean thicknesses of the basal membranes of blood vessels were 86.354 nm in the control group, 104.297 nm in group 1, and 140.181 nm in group 2. Basal membrane changes in IFN groups were dose dependent. Mitochondrial swelling, degeneration, increased diameter of vacuoles, and vacuolization in the cytoplasm of oligodendrocytes and astrocytes were also observed. IFN-alpha2b has histopathologic effects on blood vessels and cells of the optic nerve.


Asunto(s)
Interferón-alfa/efectos adversos , Vaina de Mielina/efectos de los fármacos , Nervio Óptico/efectos de los fármacos , Animales , Relación Dosis-Respuesta a Droga , Interferón alfa-2 , Masculino , Vaina de Mielina/patología , Vaina de Mielina/ultraestructura , Nervio Óptico/irrigación sanguínea , Nervio Óptico/patología , Ratas , Proteínas Recombinantes
14.
J Pediatr Surg ; 51(3): 354-9, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26411723

RESUMEN

AIM: To evaluate the remote effect of intestinal ischemia reperfusion (IR) injury mediated by tumor necrosis factor alpha (TNF-α) on diaphragm contractility functions and whether administration of NAC may counteract the possible detrimental effects in an experimental neonatal rat model. METHODS: 40 Wistar rat pups were randomized into four groups; ten animals in each. Intestinal ischemia was conducted by obstructing mesentery of intestines by a silk loop. In the control group; only laparotomy was performed. After 1h ischemia, reperfusion was conducted for 1h in 1h group, 24h for 24h group and 24h for 24h+NAC group but administration of NAC (150mg/kg/day) intraperitoneally twice a day was performed. Inflammatory response was evaluated by tissue TNF-α level and contractility functions by mechanic activity studies of the diaphragm. Electrophysiology of the diaphragm and the phrenic nerve was conducted to determine neuropathy or myopathy and transmission electron microscopy was performed to evaluate ultrastructural changes in the phrenic nerve. RESULTS: Diaphragm tissue TNF-α level significantly increased in 1h and 24h groups (P=0.004, P=0.0001; respectively). Diaphragm mechanic activation force and duration significantly decreased at 1h and 24h (P=0.004, P=0.02 and P=0.0001, P=0.0001; respectively). NAC administration significantly prevented decrease in the maximal contraction and the duration (P<0.001). Phrenic nerve compound action potential (CMAP) amplitude significantly decreased in 1h group (P<0.0001) and NAC administration significantly prevented this decrease when compared with 24h group (P<0.001). In diaphragmatic needle electromyography, the duration of motor unit potentials (MUP) was prolonged significantly when compared with control group. Contractility and electrophysiological studies were indicating primarily neuropathy in diaphragm dysfunction. Histopathology revealed axonal and myelin degeneration in the 1h and 24h group, but less injury in the NAC administered group. CONCLUSIONS: Intestinal IR induced elevation of TNF-α level in the diaphragm. Impairment in the diaphragm contractility and neuropathic changes in the phrenic nerve occurred even in the first hour of reperfusion. NAC administration prevented these detrimental effects.


Asunto(s)
Acetilcisteína/uso terapéutico , Antiinflamatorios/uso terapéutico , Diafragma/fisiopatología , Intestinos/irrigación sanguínea , Contracción Muscular/fisiología , Daño por Reperfusión/fisiopatología , Acetilcisteína/farmacología , Animales , Antiinflamatorios/farmacología , Biomarcadores/metabolismo , Diafragma/efectos de los fármacos , Diafragma/metabolismo , Diafragma/patología , Electromiografía , Intestinos/patología , Masculino , Microscopía Electrónica de Transmisión , Contracción Muscular/efectos de los fármacos , Nervio Frénico/efectos de los fármacos , Nervio Frénico/patología , Nervio Frénico/fisiopatología , Distribución Aleatoria , Ratas , Ratas Wistar , Daño por Reperfusión/tratamiento farmacológico , Resultado del Tratamiento , Factor de Necrosis Tumoral alfa/metabolismo
15.
J Matern Fetal Neonatal Med ; 29(12): 1935-40, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26305144

RESUMEN

OBJECTIVE: Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects of ß-estradiol on intestinal injury in rats. METHODS: Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia-re-oxygenation was not performed. In group 2 (saline), the rats were injected with saline after hypoxia-re-oxygenation, and the process was repeated for 5 d. In group 3 (ß-estradiol treatment), the rats were subjected to hypoxia-re-oxygenation and then given ß-estradiol intraperitoneally once a day for 5 d. After these procedures, the terminal ileum was removed for analysis. RESULTS: Statistically significant differences in histological grades were found between groups 1 and 2 (p = 0.000), groups 1 and 3 (p = 0.028), and groups 2 and 3 (p = 0.021). There were also differences in TNF-α and IL-6 levels between groups 2 and 3 (p = 0.000 and p = 0.038, respectively) and between groups 1 and 2 (p = 0.000 and p = 0.000); there was no difference between groups 1 and 3 (p = 0.574 and p = 0.195, respectively). Electron microscopy examination revealed a decrease in lipid droplets at the apical cytoplasm of the columnar cells in group 2; in group 3, the absorption of the lipids as lipid droplets was similar to that of group 1. CONCLUSION: In this study, ß-estradiol was found to decrease the intensity of intestinal injury significantly by inhibiting TNF-α and IL-6.


Asunto(s)
Enterocolitis Necrotizante/tratamiento farmacológico , Estradiol/uso terapéutico , Estrógenos/uso terapéutico , Íleon/efectos de los fármacos , Animales , Animales Recién Nacidos , Evaluación Preclínica de Medicamentos , Estradiol/farmacología , Estrógenos/farmacología , Femenino , Íleon/ultraestructura , Distribución Aleatoria , Ratas Wistar
16.
Neurol Res ; 27(1): 53-6, 2005 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-15829159

RESUMEN

OBJECTIVE: Congenital intracranial tumors are very rare and only account for 0.5-1.5% of all childhood brain tumors. The most common type of these tumors present at birth is teratomas, which represent 0.5% of all intracranial tumors. Most teratomas are midline tumors located predominantly in the sellar and pineal regions. In this study, we report a neonatal intracranial immature teratoma at the lateral ventricle because of its rare location. CASE REPORT: A 3-day-old female neonate presented with a history of irritability, vomiting, and recurrent generalized clonic seizures since birth. A head computed tomographic scan and magnetic resonance imaging disclosed a large tumor filling the right lateral ventricle and extending into the ipsilateral posterior fossa. With right parieto-occipital craniotomy, large grayish-white lobulated vascular mass was encountered and total removal of tumor was performed. Histological examination revealed the diagnosis of immature teratoma. CONCLUSION: The prognosis of congenital intracranial immature teratoma is usually poor because the lesions are extensive when they are identified. Prenatal ultrasonography is necessary for the prenatal diagnosis. Fetal magnetic resonance imaging should be made for the evaluation of intracranial tumor. If the tumor is detected before the 24 week of gestation, termination of the pregnancy should be considered.


Asunto(s)
Neoplasias del Ventrículo Cerebral/congénito , Ventrículos Laterales/patología , Teratoma/congénito , Neoplasias del Ventrículo Cerebral/patología , Preescolar , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Literatura de Revisión como Asunto , Teratoma/patología , Tomografía Computarizada por Rayos X/métodos
17.
Brain Dev ; 27(4): 308-10, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15862197

RESUMEN

Congenital muscular dystrophies (CMD) are heterogeneous group of muscle disorders with autosomal recessive inheritance. Merosin deficiency has been identified in some patients with CMD all of whom also had white matter abnormalities on MRI. In postmortem studies, the brain showed extensive myelin pallor with a spongy appearance of white matter and moderate astrocytosis or demyelination. Direct assessment of neuropathologic aspects of MN-CMD such as demyelination is possible with MR spectroscopy (MRS). Although previous reports have described several neuro-imaging findings of this disease, MRS findings have not been reported in literature. In this case, we report MRS features of a 4-year old girl with MN-CMD. MRS of brain demonstrated that N-acetylaspartate (NAA)/Creatine (Cr) ratio was normal. Increased Choline (Cho)/Cr and Myo-inositol (MI)/Cr ratios were obtained. These findings were interpreted as demyelination and gliosis of white matter.


Asunto(s)
Encéfalo/metabolismo , Encéfalo/patología , Laminina/metabolismo , Espectroscopía de Resonancia Magnética , Distrofias Musculares/metabolismo , Distrofias Musculares/patología , Preescolar , Femenino , Humanos , Imagen por Resonancia Magnética , Protones
18.
J Clin Neurosci ; 12(5): 605-8, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15993076

RESUMEN

A 54 year-old woman presented with severe headache. Neuroimaging showed an enhancing intra-axial mass in the right superior temporal region associated with severe peritumoral oedema. Preliminary diagnosis was cerebral metastasis. The mass was surgically removed. Histopathology and immunohistochemistry showed the mass to be an intraparenchymal meningioma, which is rare. The relevant literature is reviewed.


Asunto(s)
Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Lóbulo Temporal/patología , Aracnoides/patología , Edema Encefálico/etiología , Edema Encefálico/fisiopatología , Quistes del Sistema Nervioso Central/etiología , Quistes del Sistema Nervioso Central/fisiopatología , Arterias Cerebrales/patología , Diagnóstico Diferencial , Femenino , Cefalea/etiología , Cefalea/fisiopatología , Humanos , Imagen por Resonancia Magnética , Neoplasias Meníngeas/fisiopatología , Meningioma/fisiopatología , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos , Piamadre/patología , Lóbulo Temporal/irrigación sanguínea , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
19.
J Clin Neurosci ; 12(3): 318-20, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15851094

RESUMEN

Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.


Asunto(s)
Adenoma/metabolismo , Hormona de Crecimiento Humana/metabolismo , Neoplasias Hipofisarias/metabolismo , Tirotropina/metabolismo , Adenoma/patología , Adenoma/cirugía , Femenino , Prueba de Tolerancia a la Glucosa , Humanos , Inmunohistoquímica , Imagen por Resonancia Magnética , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos , Hormonas Hipofisarias/sangre , Neoplasias Hipofisarias/patología , Neoplasias Hipofisarias/cirugía , Pruebas de Función de la Tiroides
20.
Adv Ther ; 22(4): 368-80, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16418144

RESUMEN

It is well known that angiogenesis and lymphangiogenesis play important roles in tumor occurrence and progression. The vascular endothelial growth factor (VEGF) family is the most important family of proteins involved in angiogenesis, and VEGF-C is the most important molecule in lymphangiogenesis. Lymphangiogenesis plays an important role in lymphovascular invasion, metastasis to regional lymph nodes, and distant organ metastasis. In this study, the rate of VEGF-C was investigated in 217 patients with breast cancer. VEGF-C was evaluated by immunohistochemistry and its expression was compared with that of well-known prognostic indicators, such as tumor stage and grade, axillary lymph node involvement, estrogen and progesterone receptor status, c-erb-B2 expression, and extent of lymphovascular invasion. The patient population included 8 men, in addition to women before (n=108), during (n=9), and after (n=92) menopause. Patients had been diagnosed with invasive ductal (n=181) or invasive lobular (n=22) carcinoma, mixed (n=8) or medullary (n=1) carcinoma, or ductal carcinoma in situ (n=5). Tumors ranged from stage 0 to IV and grade I to III and the distribution of estrogen-positive (n=100) and estrogen-negative (n=110) receptor tumors was almost equal. The number of patients with c-erbB2 tumors ranged from 21 to 49 for each tumor stage, and the number of patients with VEGF-C-negative tumors ranged from 28 to 59 for each tumor stage. No important association between VEGF-C expression and other prognostic indicators was found. However, this may be a result of the lack of standardization among the methods used to determine VEGF-C expression. Also, the lymphangiogenic effect may not be overt because of the variety of VEGFR-3 variants, which included nonfunctional variants. To determine the relationship among angiogenesis, lymphangiogenesis, and prognosis, more standardized methods to demonstrate the angiogenesis, and prospective studies to cover a larger, more homogenous patient population are needed.


Asunto(s)
Neoplasias de la Mama Masculina/metabolismo , Neoplasias de la Mama/metabolismo , Factor C de Crecimiento Endotelial Vascular/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/análisis , Femenino , Humanos , Inmunohistoquímica , Metástasis Linfática , Masculino , Persona de Mediana Edad , Pronóstico
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