Detalles de la búsqueda
1.
Impact of ß-perfluoroalkyl substitution of proline on the proteolytic stability of its peptide derivatives.
Org Biomol Chem
; 20(47): 9337-9350, 2022 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36107003
2.
Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists.
J Enzyme Inhib Med Chem
; 36(1): 1651-1658, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34294008
3.
Exploration of the nitrogen heterocyclic periphery around the core of the advanced FFA1 agonist fasiglifam (TAK-875).
Arch Pharm (Weinheim)
; 354(4): e2000275, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33270252
4.
Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40).
Bioorg Chem
; 99: 103830, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32289588
5.
Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry.
J Enzyme Inhib Med Chem
; 35(1): 306-310, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31797704
6.
Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement.
J Enzyme Inhib Med Chem
; 35(1): 165-171, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31752557
7.
Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4.
J Mol Struct
; 12102020 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32655187
8.
Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization.
J Org Chem
; 84(23): 15106-15117, 2019 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31553875
9.
Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery.
Chemistry
; 24(21): 5444-5449, 2018 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29338097
10.
Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity.
J Org Chem
; 83(23): 14350-14361, 2018 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30358395
11.
Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline.
J Org Chem
; 83(3): 1394-1401, 2018 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29297689
12.
Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors.
Bioorg Med Chem
; 26(12): 3399-3405, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29764756
13.
Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery.
J Org Chem
; 82(18): 9627-9636, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28810741
14.
Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency.
J Enzyme Inhib Med Chem
; 32(1): 29-36, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27781494
15.
Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold.
Bioorg Med Chem
; 24(13): 2954-2963, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27229618
16.
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.
Bioorg Med Chem
; 24(21): 5481-5494, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27647366
17.
Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold.
J Enzyme Inhib Med Chem
; 31(6): 1404-10, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26899762
18.
Discovery of Strecker-type α-aminonitriles as a new class of human carbonic anhydrase inhibitors using differential scanning fluorimetry.
J Enzyme Inhib Med Chem
; 31(6): 1707-11, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26983069
19.
Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy.
Angew Chem Int Ed Engl
; 55(18): 5493-6, 2016 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-27028784
20.
Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40).
Bioorg Med Chem Lett
; 25(16): 3105-11, 2015 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26096679