[Analysis of the otorhinolaryngological doctoral theses submitted in Spain between 1976 and 2005]. / Análisis de las tesis doctorales en otorrinolaringología presentadas en España en el período 1976-2005.

INTRODUCTION AND OBJECTIVE: The importance of otorhinolaryngology as a separate branch of medicine has grown in the last decades. The objective of this work is to analyze the doctoral theses in ENT presented in Spain between 1976 and 2005. METHODS: The TESEO database was searched for theses on otorhinolaryngology produced in Spain between 1976 and 2005. The search criteria used were the terms "Otorhinolaryngology," "Ear, nose, and throat surgery," "Hearing physiology," "Vestibular physiology," "Hearing physics," and "Bioacoustics". RESULTS: 468 theses were found (15.6 theses/year). Of these, 343 (73.6 %) were submitted by otorhinolaryngologists. The Universities of Valencia (Estudi General) (49), Complutense of Madrid (42), Salamanca (39), Barcelona (35), and Autònoma of Barcelona (31) accounted for most of the theses. The name of the supervisor was listed in 376 of the 468 theses (80.4 %); 286 of them had only 1 supervisor (76.1 %) and 90 had 2 (23.9 %). The most frequent topics were otology and audiology (35.1 %). CONCLUSIONS: Otorhinolaryngology in Spain has produced a similar number of theses as other areas of knowledge evaluated. The supervision of theses has tended to be shared in the most recent years studied. The number of theses submitted each year did not have only academic influences but also non-academic reasons.

Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.

Lysyl oxidase-like 2 (Loxl2) interacts with and stabilizes Snai1 transcription factor, promoting epithelial-mesenchymal transition. Either Loxl2 or Snai1 knock-down blocks tumor growth and induces differentiation, but the specific role of each factor in tumor progression is still unknown. Comparison of the gene expression profiles of the squamous cell carcinoma cell line HaCa4 after knocking-down Loxl2 or Snai1 revealed that a subset of epidermal differentiation genes was specifically up-regulated in Loxl2-silenced cells. In agreement, although both Loxl2- and Snai1-knockdown cells showed reduced in vivo invasion, only Loxl2-silenced cells exhibited a skin-like epidermal differentiation program. In addition, we show that expression of Loxl2 and Snai1 correlates with malignant progression in a two-stage mouse skin carcinogenesis model. Furthermore, we found that increased expression of both LOXL2 and SNAI1 correlates with local recurrence in a cohort of 256 human laryngeal squamous cell carcinomas. We describe for the first time that high levels of LOXL2 are associated with decreased overall and disease-free survival in laryngeal squamous cell carcinomas, lung squamous cell carcinoma, and lymph node-negative (N(0)) breast adenocarcinomas. Altogether, our results show that LOXL2 can be used as a new poor prognosis indicator in human squamous cell carcinomas promoting malignant transformation by both SNAI1-dependent and SNAI1-independent pathways.

Kaposiform hemangioendothelioma of the external auditory canal in an adult.

BACKGROUND: Kaposiform hemangioendothelioma is an uncommon vascular tumor initially reported to occur exclusively in children. METHODS: The presentation, pathologic evaluation, and management of an unusual case of kaposiform hemangioendothelioma is presented and discussed. RESULTS: A 27-year-old HIV-negative man was initially seen with a reddish nodule located in the outer third of the external auditory canal. Histologically, the tumor was composed of spindle-shaped cells arranged in short fascicles associated with small endothelial-like vascular spaces, similar in appearance to Kaposi's sarcoma. The lesion was locally excised but recurred 1 month later; then radiation therapy was performed. The patient remains well at 5-year follow-up. CONCLUSIONS: Recognition of kaposiform hemangioendothelioma is important to avoid possible confusion with a variety of vascular neoplasms with different biologic potential. This case presented some diagnostic difficulty because of the age of the patient and the unusual location of the lesion and had to be mainly distinguished from Kaposi's sarcoma.