1.
Bioorg Med Chem Lett
; 24(3): 845-9, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24405707
RESUMEN
Calcitonin gene-related peptide (CGRP) has been implicated in acute migraine pathogenesis. In an effort to identify novel CGRP receptor antagonists for the treatment of migraine, we have discovered thiazolidinone 49, a potent (Ki=30 pM, IC50=1 nM), orally bioavailable, CNS-penetrant CGRP antagonist with good pharmacokinetic properties.