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1.
Front Neuroendocrinol ; 74: 101145, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38862092

RESUMEN

Understanding emotions in males is crucial given their higher susceptibility to substance use, interpersonal violence, and suicide compared to females. Steroid hormones are assumed to be critical biological factors that affect and modulate emotion-related behaviors, together with psychological and social factors. This review explores whether males' abilities to recognize emotions of others and regulate their own emotions are associated with testosterone, cortisol, and their interaction. Higher levels of testosterone were associated with improved recognition and heightened sensitivity to threatening faces. In contrast, higher cortisol levels positively impacted emotion regulation ability. Indirect evidence from neuroimaging research suggested a link between higher testosterone levels and difficulties in cognitive emotion regulation. However, this notion must be investigated in future studies using different emotion regulation strategies and considering social status. The present review contributes to the understanding of how testosterone and cortisol affect psychological well-being and emotional behavior in males.


Asunto(s)
Regulación Emocional , Hidrocortisona , Testosterona , Humanos , Masculino , Hidrocortisona/metabolismo , Regulación Emocional/fisiología , Testosterona/metabolismo , Testosterona/fisiología , Emociones/fisiología , Estrés Psicológico/metabolismo , Reconocimiento en Psicología/fisiología
2.
Proc Natl Acad Sci U S A ; 119(5)2022 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-35082150

RESUMEN

Aggression is known to be regulated by pheromonal information in many species. But how central brain neurons processing this information modulate aggression is poorly understood. Using the fruit fly model of Drosophila melanogaster, we systematically characterize the role of a group of sexually dimorphic GABAergic central brain neurons, popularly known as mAL, in aggression regulation. The mAL neurons are known to be activated by male and female pheromones. In this report, we show that mAL activation robustly increases aggression, whereas its inactivation decreases aggression and increases intermale courtship, a behavior considered reciprocal to aggression. GABA neurotransmission from mAL is crucial for this behavior regulation. Exploiting the genetic toolkit of the fruit fly model, we also find a small group of approximately three to five GABA+ central brain neurons with anatomical similarities to mAL. Activation of the mAL resembling group of neurons is necessary for increasing intermale aggression. Overall, our findings demonstrate how changes in activity of GABA+ central brain neurons processing pheromonal information, such as mAL in Drosophila melanogaster, directly modulate the social behavior of aggression in male-male pairings.


Asunto(s)
Agresión/fisiología , Conducta Animal/fisiología , Encéfalo/metabolismo , Proteínas de Drosophila/metabolismo , Drosophila melanogaster/metabolismo , Interneuronas/metabolismo , Ácido gamma-Aminobutírico/metabolismo , Animales , Cortejo , Masculino , Neuronas/metabolismo , Feromonas/metabolismo , Conducta Sexual Animal/fisiología , Conducta Social
3.
J Infect Dis ; 2024 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-39213380

RESUMEN

BACKGROUND: Australia introduced a national HPV vaccination program for girls in 2007 and boys in 2013, achieving high coverage in both populations. We assessed HPV prevalence among men who have sex with women (MSW) and men who have sex with men (MSM) aged 18-35 years and examined program effects by vaccination status. METHODS: Men recruited between 2015-2018 self-collected a penile or intra-anal swab for HPV genotyping. HPV vaccination status was confirmed with the National Register. HPV prevalence was examined by age groups and vaccination status. RESULTS: Of 1,625 men included (median age 27 years; IQR [23-30]), 231 (14.2%) were vaccinated, and 1,370 (84.3%) were unvaccinated. Among 984 MSW, the prevalence of quadrivalent vaccine-targeted HPV types (6,11,16,18) was 10.6% (95%CI: 8.7-12.8) in unvaccinated and 10.7% (5.7-19.3%) in vaccinated men (p=0.96). Prevalence was lowest in the youngest age groups regardless of vaccination status. Among MSM, quadrivalent HPV type prevalence was 40.3% (36.0-44.8%) in unvaccinated and 29.9% (23.1-37.8%) in vaccinated men (p=0.02). In unvaccinated MSM, prevalence was high regardless of age, whereas among vaccinated MSM, prevalence was lowest in the youngest age-group (p=0.001). Among those with confirmed doses, quadrivalent HPV types were detected in 0% (0-7.7%; n=46) of men who had their first dose at 13-19 years and 37.2% (27.5-47.8%; n=94) of those who received their first dose at 20 years or older. CONCLUSION: Our data demonstrates the importance of universal adolescent HPV vaccination to ensure MSM receive the same benefits as MSW.

4.
Proc Biol Sci ; 291(2019): 20240099, 2024 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-38503332

RESUMEN

In many species, establishing and maintaining a territory is critical to survival and reproduction, and an animal's ability to do so is strongly influenced by the presence and density of competitors. Here we manipulate social conditions to study the alternative reproductive tactics displayed by genetically identical, age-matched laboratory mice competing for territories under ecologically realistic social environmental conditions. We introduced adult males and females of the laboratory mouse strain C57BL/6J into a large, outdoor field enclosure containing defendable resource zones under one of two social conditions. We first created a low-density social environment, such that the number of available territories exceeded the number of males. After males established stable territories, we introduced a pulse of intruder males and observed the resulting defensive and invasive tactics employed. In response to this change in social environment, males with large territories invested more in patrolling but were less effective at excluding intruder males as compared with males with small territories. Intruding males failed to establish territories and displayed an alternative tactic featuring greater exploration as compared with genetically identical territorial males. Alternative tactics did not lead to equal reproductive success-males that acquired territories experienced greater survival and had greater access to females.


Asunto(s)
Conducta Sexual Animal , Condiciones Sociales , Masculino , Femenino , Ratones , Animales , Conducta Sexual Animal/fisiología , Ratones Endogámicos C57BL , Territorialidad , Reproducción/fisiología
5.
Curr Top Microbiol Immunol ; 441: 139-183, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37695428

RESUMEN

Tuberculosis remains a daunting public health concern in many countries of the world. A consistent observation in the global epidemiology of tuberculosis is an excess of cases of active pulmonary tuberculosis among males compared with females. Data from both humans and animals also suggest that males are more susceptible than females to develop active pulmonary disease. Similarly, male sex has been associated with poor treatment outcomes. Despite this growing body of evidence, little is known about the mechanisms driving sex bias in tuberculosis disease. Two dominant hypotheses have been proposed to explain the predominance of active pulmonary tuberculosis among males. The first is based on the contribution of biological factors, such as sex hormones and genetic factors, on host immunity during tuberculosis. The second is focused on non-biological factors such as smoking, professional exposure, and health-seeking behaviors, known to be influenced by gender. In this chapter, we review the literature regarding these two prevailing hypotheses by presenting human but also experimental animal studies. In addition, we presented studies aiming at examining the impact of sex and gender on other clinical forms of tuberculosis such as latent tuberculosis infection and extrapulmonary tuberculosis, which both appear to have their own specificities in relation to sex. We also highlighted potential intersections between sex and gender in the context of tuberculosis and shared future directions that could guide in elucidating mechanisms of sex-based differences in tuberculosis pathogenesis and treatment outcomes.


Asunto(s)
Tuberculosis Extrapulmonar , Tuberculosis Pulmonar , Tuberculosis , Animales , Femenino , Humanos , Masculino , Factores Sexuales , Tuberculosis/tratamiento farmacológico , Tuberculosis Pulmonar/tratamiento farmacológico
6.
Amino Acids ; 56(1): 8, 2024 Feb 05.
Artículo en Inglés | MEDLINE | ID: mdl-38315260

RESUMEN

Plant-derived proteins are generally believed to possess lesser anabolic properties when compared with animal-derived proteins. This is, at least partly, attributed to the lower leucine content of most plant-derived proteins. Corn protein has a leucine content that is highest among most plant-derived proteins and it even exceeds the levels observed in animal-derived proteins such as whey protein. Therefore, this study aimed to compare muscle protein synthesis rates following the ingestion of 30 g corn protein and a 30 g blend of corn plus milk protein with 30 g milk protein. In a randomized, double blind, parallel-group design, 36 healthy young males (26 ± 4 y) received primed continuous L-[ring-13C6]-phenylalanine infusions and ingested 30 g corn protein (CORN), 30 g milk protein (MILK), or a 30 g proteinblend with 15 g corn plus 15 g milk protein (CORN + MILK). Blood and muscle biopsies were collected for 5 h following protein ingestion to assess post-prandial plasma amino acid profiles and myofibrillar protein synthesis rates. The results show that Ingestion of protein increased myofibrillar protein synthesis rates from basal post-absorptive values in all treatments(P < 0.001). Post-prandial myofibrillar protein synthesis rates did not differ between CORN vs MILK (0.053 ± 0.013 vs 0.053 ± 0.013%∙h-1, respectively; t-test P = 0.90), or between CORN + MILK vs MILK (0.052 ± 0.024 vs 0.053 ± 0.013%∙h-1, respectively; t-test P = 0.92). Ingestion of 30 g corn protein, 30 g milk protein, or a blend of 15 g corn plus 15 g milk protein robustly increases muscle protein synthesis rates in young males. The muscle protein synthetic response to the ingestion of 30 g corn-derived protein does not differ from the ingestion of an equivalent amount of milk protein in healthy, young males. Clinical Trial Registry number. NTR6548 (registration date: 27-06-2017) https://www.trialregister.nl/ .


Asunto(s)
Proteínas de la Leche , Proteínas Musculares , Masculino , Proteínas en la Dieta/metabolismo , Ingestión de Alimentos , Leucina/metabolismo , Proteínas Musculares/metabolismo , Músculo Esquelético/metabolismo , Proteínas de Plantas/metabolismo , Zea mays/metabolismo , Humanos , Adulto Joven , Adulto
7.
Cancer Control ; 31: 10732748241237328, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38454302

RESUMEN

INTRODUCTION: Human papillomavirus (HPV) vaccination rates are lower than other recommended adolescent vaccines. Cancer survivor narratives are used to promote cancer prevention and control, but little is known about their impact on adolescent HPV vaccination. OBJECTIVE: This pilot study explored the feasibility and effects of a video education intervention using a cancer survivor narrative to improve parents' attitudes toward and intentions to get the HPV vaccine. METHODS: This study utilized a one-group design; participants completed a pre-intervention survey, watched the video before attending their sons' wellness visits, and completed a post-intervention survey within one week of their appointment. Using the narrative persuasion framework, we developed a 4-minute video of a local HPV-related cancer survivor to promote the HPV vaccine as cancer prevention. We recruited 37 participants between June and October 2020. Participants were parents of males ages 9-17 who had not yet initiated HPV vaccination. RESULTS: After the video, more parents agreed that HPV vaccination is safe (pre: 66% vs. post: 82%; P = .045) and that their child's chances of getting HPV-related cancer in the future are high (pre: 24% vs. post: 46%; P = .014). Overall, 91% of parents felt the cancer survivor story helped them understand the risks of HPV cancers, and 52% said the story influenced their decision to start HPV vaccination for their child. CONCLUSIONS: Our findings suggest that cancer survivor narratives influence parents' vaccine opinions and understanding of their child's risk of HPV infection, leading to increased parental intent to get the HPV vaccine for their adolescent males.


Asunto(s)
Supervivientes de Cáncer , Neoplasias , Infecciones por Papillomavirus , Vacunas contra Papillomavirus , Masculino , Adolescente , Niño , Humanos , Proyectos Piloto , Vacunas contra Papillomavirus/uso terapéutico , Infecciones por Papillomavirus/complicaciones , Infecciones por Papillomavirus/prevención & control , Intención , Neoplasias/prevención & control , Conocimientos, Actitudes y Práctica en Salud
8.
Artículo en Inglés | MEDLINE | ID: mdl-39230833

RESUMEN

PURPOSE: This study aimed to investigate Human papillomavirus (HPV) infection and genotyping in men from Chongqing and analyze age-related trends to provide insights for HPV prevention and vaccination plans tailored for men in Chongqing, China. METHODS: This study is an observational study. We investigated male patients who underwent HPV screening at two hospitals in Chongqing from 2017 to 2022, totaling 4,381 cases, aged 18 to 85. HPV genotyping was conducted using the Hybribio Rapid GenoArray kit. RESULTS: Among the 4,381 men, the overall HPV prevalence was 14.9%, peaking at 19.3% in 2022. Single HPV infection was 11.5%, and multiple infection was 3.4%. The most prevalent genotypes were HPV-52, HPV-16, and HPV-58. Single high-risk HPV infection peaked in the 36-45 age group, while multiple high-risk HPV infection decreased with age (P-trend < 0.01). Prevalence in the ≤ 25 age group was 3.7%. Single low-risk HPV infection also decreased with age (P-trend = 0.03). Genotypes covered by the nonavalent vaccine had the highest prevalence, increasing with age. Co-infection of HPV-16 with HPV-52 and HPV-58 was common. Single HPV infections were prevalent in cases of urethritis (30.8%), anogenital warts (36.4%), and genital warts (26.3%), while multiple HPV infections were significant in anogenital warts (18.2%). CONCLUSIONS: Single HPV infection was predominant in Chongqing, with HPV-52, HPV-16, HPV-58, HPV-53, and HPV-39 being the most prevalent genotypes. The prevalence of genotypes covered by the nonavalent vaccine increased with age. This study offers valuable insights for developing male-specific HPV prevention strategies in Chongqing.

9.
Fish Shellfish Immunol ; : 109921, 2024 Sep 23.
Artículo en Inglés | MEDLINE | ID: mdl-39321908

RESUMEN

Sexual dimorphism in immunity has been extensively documented across vertebrates, with marked contrasts observed in immune responses between males and females. These variations are mainly attributed to oestrogens conferring enhanced immune responses in females, while males exhibit greater susceptibility to pathogens. However, in the light of the data, consensus is lacking, as different physiological and environmental factors such, as epigenetics, may impact sex-biased immunity. In fish, the regulation of immune responses through sex hormones is primarily determined by the leucocyte function, which contains sex steroid receptors. However, comparative sex-based research in fish immunity is still very limited. This study aimed to evaluate, for the first time, the disparities between males and females yellowtail kingfish (Seriola lalandi) juveniles in several parameters of local humoral innate immunity related to mucosae (skin mucus and foregut homogenates) and reproductive tissue (ovary and testis homogenates), as well as in serum. We investigated the sexual dimorphism in the expression patterns of genes coding for antimicrobial peptides, antiviral markers, and cytokines. Our findings revealed that the yellowtail kingfish males exhibit significantly higher levels of innate immune parameters, both functionally and transcriptionally, compared to females. These results suggest that females may have a higher susceptibility to pathogen infections, potentially leading to latent infections, which deservers further investigations. Understanding these sex-based differences in immunity could guide breeding strategies improvements and disease management in aquaculture facilities.

10.
BMC Endocr Disord ; 24(1): 50, 2024 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-38654196

RESUMEN

BACKGROUND: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is an endemic chronic disease which is characterized with progressive depletion of CD4 T cells and increased susceptibility to opportunistic infections. Previous studies have associated HIV infection with increased hypogonadism. However, the prevalence of hypogonadism remained poorly defined and widely ranging in various studies. This study aims to evaluate the serum gonadal hormonal levels and hypogonadism in antiretroviral therapy (ART) naïve newly diagnosed HIV infected-males in Mwanza, Tanzania. METHODS: This was a comparison study involving 81 ART naïve newly diagnosed HIV-infected adult males as study group and 81 apparently healthy HIV-negative males as comparison group. The participants in the study group and comparison group were matched by body mass index and age. Serum hormones [Total testosterone (TT), follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E) were estimated. Serum testosterone < 300 ng/dl, or testosterone > 300 ng/dl with high LH and FSH (compensatory hypogonadism) were taken as markers of hypogonadism. Data were analyzed using STATA version 15. RESULTS: The median serum testosterone level among ART naïve newly diagnosed HIV-infected adult males was significantly lower as compared to their comparison group (447 [259-534] versus 517 [396-605]; p = 0.0074) and shown to decrease with decreasing CD4 level. The median [IQR] serum FSH level among ART naïve newly diagnosed HIV-infected adult males was significantly higher than among their comparison group (3.8 [2.1-6.5] versus 2.6 [1.8-4.2]; p = 0.0086). The differences in serum LH and Estradiol were not statistically significant. Furthermore, the proportion of hypogonadism was significantly higher among ART naïve newly diagnosed HIV-infected adult males than in their comparison group (37.0% [30/81] versus 14.8% [12/81]; p = 0.0006). Out of these 30, 24 HIV-infected males had secondary hypogonadism, one had primary, and the remaining five had compensatory hypogonadism. CONCLUSION: Serum testosterone was lower and follicle stimulating hormone was higher among ART naïve HIV-infected males as compared to the HIV negative controls. Hypogonadism, mainly secondary, is common endocrine abnormality among ART naïve HIV-infected male patients in this study. HIV is associated with variations in gonadal hormones which may lead to sexual dysfunction in infected individuals.


Asunto(s)
Infecciones por VIH , Hipogonadismo , Testosterona , Humanos , Masculino , Adulto , Infecciones por VIH/sangre , Infecciones por VIH/complicaciones , Infecciones por VIH/epidemiología , Hipogonadismo/sangre , Hipogonadismo/epidemiología , Hipogonadismo/etiología , Hipogonadismo/diagnóstico , Tanzanía/epidemiología , Testosterona/sangre , Hormona Luteinizante/sangre , Hormona Folículo Estimulante/sangre , Persona de Mediana Edad , Adulto Joven , Hormonas Gonadales/sangre , Estudios de Casos y Controles , Estradiol/sangre , Biomarcadores/sangre , Estudios de Seguimiento
11.
BMC Cardiovasc Disord ; 24(1): 288, 2024 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-38816791

RESUMEN

Clinical risk factors associated obesity and smoking, as well as their combined effect, are not fully understood. This study aims to determine sex differences in risk factors in a population of acute ischemic stroke (AIS) patients who are obese and with a history of previous or current smoking. METHODS: A retrospective analysis of risk factors in male and female AIS patients with baseline data of obesity and current or previous history of smoking, smoking, and obesity alone was determined. The primary predictor and outcome are risk factors associated with male and female AIS patients. Baseline risk factors were analyzed using a multivariate regression analysis to determine specific risk factors linked with the combined effect of obesity and current or previous history of smoking''. RESULTS: Male obese AIS patients who are current or previous smokers were more likely to be older patients(OR = 1.024, 95% CI, 1.022-1.047, P = 0.033) that present with coronary artery disease (OR = 1.806, 95% CI, 1.028-3.174, P = 0.040), a history of alcohol use (OR = 2.873, 95% CI, 1.349-6.166, P = 0.006), elevated serum creatinine (OR = 4.724, 95% CI, 2.171-10.281, P < 0.001) and systolic blood pressure (OR = 1.029, 95% CI, 1.011-1.047, P < 0.002). Females were more associated with depression (OR = 0.432, 95% CI, 0.244-0.764, P = 0.004), previous TIA (OR = 0.319, 95% CI, 0.142-0.714, P < 0.005), and higher levels of HDL (OR = 0.938, 95% CI, 0.915-0.962, P < 0.001). CONCLUSION: Our results reveal sex differences in risk factors in obese AIS patients with a current or past history of smoking. This finding emphasizes the need to develop management strategies to improve the care of obese AIS patients who are either current or former smokers.


Asunto(s)
Accidente Cerebrovascular Isquémico , Obesidad , Fumar , Humanos , Masculino , Femenino , Factores de Riesgo , Obesidad/epidemiología , Obesidad/diagnóstico , Estudios Retrospectivos , Persona de Mediana Edad , Anciano , Factores Sexuales , Fumar/efectos adversos , Fumar/epidemiología , Accidente Cerebrovascular Isquémico/epidemiología , Accidente Cerebrovascular Isquémico/diagnóstico , Accidente Cerebrovascular Isquémico/etiología , Medición de Riesgo , Disparidades en el Estado de Salud , Ex-Fumadores , Anciano de 80 o más Años , Pronóstico
12.
Pacing Clin Electrophysiol ; 47(7): 869-877, 2024 07.
Artículo en Inglés | MEDLINE | ID: mdl-38605573

RESUMEN

BACKGROUND: Several studies have demonstrated that females have a higher risk of arrhythmia recurrence after pulmonary vein (PV) isolation for atrial fibrillation (AF). There are limited data on sex-based differences in PV reconnection rates at repeat ablation. We aimed to investigate sex-based differences in electrophysiological findings and atrial arrhythmia recurrence after repeat AF ablation METHODS: We conducted a retrospective study of 161 consecutive patients (32% female, age 65 ± 10 years) who underwent repeat AF ablation after index PV isolation between 2010 and 2022. Demographics, procedural characteristics and follow-up data were collected. Recurrent atrial tachycardia (AT)/AF was defined as any atrial arrhythmia ≥30 s in duration. RESULTS: Compared to males, females tended to be older and had a significantly higher prevalence of prior valve surgery (10 vs. 2%; P = .03). At repeat ablation, PV reconnection was found in 119 (74%) patients. Males were more likely to have PV reconnection at repeat ablation compared to females (81 vs. 59%; P = .004). Excluding repeat PV isolation, there were no significant differences in adjunctive ablation strategies performed at repeat ablation between females and males. During follow-up, there were no significant differences in freedom from AT/AF recurrence between females and males after repeat ablation (63 vs. 59% at 2 years, respectively; P = .48). CONCLUSIONS: After initial PV isolation, significantly fewer females have evidence of PV reconnection at the time of repeat ablation for recurrent AF. Despite this difference, long-term freedom from AT/AF was similar between females and males after repeat ablation.


Asunto(s)
Fibrilación Atrial , Ablación por Catéter , Venas Pulmonares , Recurrencia , Reoperación , Humanos , Fibrilación Atrial/cirugía , Fibrilación Atrial/fisiopatología , Venas Pulmonares/cirugía , Masculino , Femenino , Ablación por Catéter/métodos , Estudios Retrospectivos , Anciano , Factores Sexuales , Persona de Mediana Edad
13.
Arch Sex Behav ; 53(7): 2765-2775, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38528296

RESUMEN

In the United States, HIV prevalence is increasing in rural areas, specifically among rural adolescent sexual minority males (ASMM). However, it is unclear what HIV sexual risk behaviors rural ASMM engage in and what HIV preventative services they utilize. This study aimed to (1) document the lifetime HIV sexual risk behaviors and service utilization of rural ASMM and (2) compare rural-urban differences in the prevalence of HIV sexual risk behaviors and service utilization. We analyzed data collected from 1615 ASMM who participated in a baseline survey for an online HIV prevention program from April 2018 to June 2020. We compared the prevalence of lifetime HIV sexual risk behaviors and HIV healthcare utilization among rural and urban participants via descriptive statistics, chi-square tests, linear and logistic regressions, and zero-inflated Poisson regressions. These analyses indicated that rural ASMM were more likely than urban ASMM to engage in condomless sex when they had anal sex. Rural ASMM could benefit from offline and online evidence-based HIV prevention interventions, especially interventions that increase condom use.


Asunto(s)
Infecciones por VIH , Asunción de Riesgos , Población Rural , Conducta Sexual , Minorías Sexuales y de Género , Población Urbana , Humanos , Masculino , Adolescente , Población Rural/estadística & datos numéricos , Infecciones por VIH/prevención & control , Infecciones por VIH/epidemiología , Población Urbana/estadística & datos numéricos , Minorías Sexuales y de Género/estadística & datos numéricos , Minorías Sexuales y de Género/psicología , Estados Unidos/epidemiología , Conducta Sexual/estadística & datos numéricos , Aceptación de la Atención de Salud/estadística & datos numéricos , Adulto Joven , Conducta del Adolescente/psicología , Sexo Inseguro/estadística & datos numéricos , Prevalencia
14.
World J Surg ; 48(5): 1190-1197, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38517350

RESUMEN

BACKGROUND: While males present with more adverse clinicopathologic features in papillary thyroid carcinoma (PTC), younger age has previously been shown to be a favorable prognostic factor. We examined the combined effect of male sex and young age on PTC outcomes. METHODS: We conducted a retrospective analysis of a prospectively maintained database of thyroid cancer surgery patients (2000-2020) at a single quaternary care institution. We included papillary thyroid carcinoma cases and excluded those with prior cancer-related thyroid surgery. We examined demographics, cancer stage, surgical outcomes, and complications by age and sex, analyzing groups below and above the age of 40 years. RESULTS: A total of 680 patients with PTC were included. Females constituted 68% (age ≥40 years: 44% and <40 years: 24%) and males 32% (≥40 years: 24% and <40 years: 8%). A significant difference (p < 0.001) of N1 disease distribution was found between the groups. N1a metastasis was greater in patients younger than 40 regardless of sex ((M < 40 (15%), F < 40 (15%), M ≥ 40 (12%), and F ≥ 40 (9%)). While, M < 40 had greater N1b metastasis (36%) than all other groups (M ≥ 40 (28%), F < 40 (22%), and F ≥ 40 (10%)). There was no significant difference in the distribution of T stages between groups. Groups showed no differences in 30-day outcomes, recurrence at 1 year, reoperation, mortality, nerve injury, or hypocalcemia. CONCLUSIONS: Young males with PTC face increased occurrence of nodal metastasis yet experience similar recurrence rates as their female and older counterparts. Subgroup analysis underscores the predictive role of sex and age in advanced PTC cases.


Asunto(s)
Cáncer Papilar Tiroideo , Neoplasias de la Tiroides , Tiroidectomía , Humanos , Masculino , Adulto , Cáncer Papilar Tiroideo/cirugía , Cáncer Papilar Tiroideo/patología , Cáncer Papilar Tiroideo/mortalidad , Femenino , Estudios Retrospectivos , Neoplasias de la Tiroides/cirugía , Neoplasias de la Tiroides/patología , Neoplasias de la Tiroides/mortalidad , Tiroidectomía/métodos , Persona de Mediana Edad , Factores de Edad , Factores Sexuales , Estadificación de Neoplasias , Resultado del Tratamiento , Anciano , Complicaciones Posoperatorias/epidemiología , Pronóstico , Recurrencia Local de Neoplasia/epidemiología
15.
BMC Psychiatry ; 24(1): 31, 2024 01 08.
Artículo en Inglés | MEDLINE | ID: mdl-38191340

RESUMEN

OBJECTIVE: With cancer the second deadliest disease in the world, worry about cancer can have mental health or psychiatric implications. This study examines the prevalence, differences, and influence of cancer worry (CW), its interaction effect with age, and other confounders on self-reported depressive symptoms (SRDS) among adult males and females in the US. METHODS: We utilized a nationally representative sample data of 2,950 individuals (males = 1,276; females = 1,674) from Cycle 4 of the Health Information National Trends Survey 5 (HINTS 5) 2020. Using frequencies, bivariate chi-square test, and multivariate logistic regression, we examined the prevalence, difference, and association of CW with SRDS, adjusting for confounders. RESULTS: The prevalence rate of SRDS was found to be 32% among females and 23.5% among males. Among individuals with CW, females had a higher prevalence of SRDS compared to males (40.5% vs. 35.1%). However, there was a significant difference in the likelihood of experiencing SRDS between males and females with CW, with males having 84% increased risk compared to females. Across all age groups, the multivariate analysis of the relationship between CW and SRDS revealed that both males and females showed a significantly decreased likelihood of SRDS compared to those aged 18-34 years. However, males aged 35 years or older exhibited an even more pronounced decrease in likelihood compared to females in the same age group. Nonetheless, when examining the interaction of age and CW, we observed a significantly increased likelihood of SRDS across all age groups. Males, in particular, had a higher increased likelihood of SRDS compared to females across all ages, except for those aged 75 years and older. CONCLUSION: The findings of this study highlight the significant influence of CW on individuals' SRDS and the modifying effect of age, particularly among males. These results are important for a better understanding of the risk of CW on mental health, which can be a preventive strategy or control mechanism.


Asunto(s)
Depresión , Neoplasias , Adulto , Masculino , Humanos , Femenino , Anciano , Autoinforme , Depresión/epidemiología , Salud Mental , Análisis Multivariante
16.
Int J Med Sci ; 21(13): 2494-2501, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39439457

RESUMEN

The most general cancer in men is prostate cancer (PCa), with its risk increasing due to age and obesity. Visfatin, a member of adipokines, is related to cancer progression and metastasis, but its relationship in PCa remains undetermined. In addition, no knowledge is available regarding relations between visfatin polymorphisms and clinicopathological characteristics in PCa. We sought to investigate the functions of four visfatin gene polymorphisms and clinicopathological characteristics on the hazard of developing PCa in 695 Taiwanese males with PCa. Carriers of the GA+AA heterozygote of SNP rs61330082 were at a markedly higher risk of biochemical recurrence than those with the GG genotype. Visfatin rs61330082 and rs11977021 were related with a high risk of perineural invasion, lymphovascular invasion, and biochemical recurrence in prostate-specific antigen (PSA) > 10 PCa patients. The Cancer Genome Atlas database noted that visfatin mRNA level did not prominently differ with pathological T/N stage and overall survival. This finding is the first to document a connection between visfatin polymorphisms and clinicopathological characteristics of PCa in Taiwanese males.


Asunto(s)
Nicotinamida Fosforribosiltransferasa , Polimorfismo de Nucleótido Simple , Neoplasias de la Próstata , Humanos , Masculino , Nicotinamida Fosforribosiltransferasa/genética , Neoplasias de la Próstata/genética , Neoplasias de la Próstata/patología , Taiwán/epidemiología , Anciano , Persona de Mediana Edad , Predisposición Genética a la Enfermedad , Genotipo , Estudios de Asociación Genética , Citocinas/genética , Antígeno Prostático Específico/sangre
17.
BMC Public Health ; 24(1): 1285, 2024 May 10.
Artículo en Inglés | MEDLINE | ID: mdl-38730388

RESUMEN

BACKGROUND: Despite growing recognition of loneliness as a global public health concern, research on its occurrence and precipitants among men across different life stages remains limited and inconclusive. This study aims to address this gap by investigating the prevalence and predictors of loneliness among a large, representative data set of Australian adult men. METHODS: The study used longitudinal data from waves 2-21 of the Household, Income and Labour Dynamics in Australia (HILDA) Survey, including men aged 15-98. Estimating linear fixed effects regressions that account for unobserved time-invariant individual heterogeneity, a single-item measure of loneliness was regressed on a set of selected explanatory variables over different parts of the life course. RESULTS: Increased social isolation, romantic partnership dissolution, having a long-term disability, and stronger beliefs that the man, rather than the woman, should be the breadwinner of the household, are associated with greater loneliness. Frequent social connection, having a romantic partner, and high neighbourhood satisfaction are protective against loneliness. The findings also reveal several differences in the predictors of loneliness over the life course. Job security is especially important for younger men, whereas for older men volunteering and less conservative gender role attitudes are important factors that can decrease loneliness. CONCLUSIONS: The results emphasise the need to consider age-specific factors and societal expectations in understanding and addressing loneliness amongst men. Additionally, the findings underscore the importance of raising awareness about the impact of societal norms and expectations on men's mental health. The results offer valuable insights for policymakers, healthcare providers, and researchers to develop effective strategies and support systems to combat loneliness and promote well-being among men.


Asunto(s)
Soledad , Humanos , Soledad/psicología , Masculino , Estudios Longitudinales , Australia , Adulto , Persona de Mediana Edad , Anciano , Adulto Joven , Adolescente , Anciano de 80 o más Años , Factores de Riesgo , Aislamiento Social/psicología
18.
Appetite ; 203: 107727, 2024 Oct 22.
Artículo en Inglés | MEDLINE | ID: mdl-39447648

RESUMEN

Eating behavior can be influenced by external factors; however, there is no consensus on the existence of differences in eating behavior between the sexes in stressful situations, such as the COVID-19 pandemic. This systematic review assessed whether there was a difference in eating behavior between sexes during the COVID-19 pandemic. A search of nine databases (Medline/Pubmed, Embase, Scielo, VHL, Scopus, PsycINFO, Web of Science, ProQuest, Google Scholar) was conducted in October 2023. Studies reporting eating behaviors in males and females during the COVID-19 pandemic were included. Methodological quality was assessed using the Joanna Briggs Institute Critical Appraisal Instrument. Stratified meta-analyses were conducted using the STATA software. Of the 2388 studies identified, 45 were included in the qualitative synthesis, and 36 in the meta-analysis, encompassing a total of 35,792 participants. Validated questionnaires were used to assess eating behavior, including the TFEQ (33.3%), DEBQ (24.4%), EEQ (22.2%), EES (11.1%), EOQ-5 (2.2%), AEBQ (2.2%), EAS (2.2%), and EMAQ (2.2%). Overall, males exhibited lower scores in emotional eating (Cohen's d = -0.32, 95%CI: 0.46 to -0.17) and restrained eating (Hedges'g = -0.11, 95%CI: 0.16 to -0.06) compared to females. However, the subgroup analysis indicated no differences in emotional eating (subgroup difference p = 0.39) or restrained eating (subgroup difference p = 0.30) according to the year of pandemic. These findings underscore the importance of sex-specific interventions, the address eating behaviors during periods of heightened insecurity in worldwide health emergencies, such as the COVID-19 pandemic. Additionally, our results emphasize the necessity for public health strategies to monitor and promote healthy eating behaviors to mitigate their impact on overall health outcomes, even in males, as their eating behavior may be affected over the course of a global health crisis, as well as females.

19.
Adv Exp Med Biol ; 1463: 365-370, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39400849

RESUMEN

The aim of this study was to investigate the skeletal muscle O2 dynamics during body-weight resistance exercise with slow movement and tonic force generation. Thirteen untrained, healthy, young males performed Bulgarian split squats and push-ups until volitional failure. Relative changes from rest in oxygenated haemoglobin (oxy-Hb) and deoxygenated haemoglobin (deoxy-Hb) concentrations were continuously monitored at the vastus lateralis (VL) and rectus femoris (RF) muscles during squats, and pectoralis major (PM) and triceps brachii (TB) muscles during push-ups using spatial resolved near-infrared spectroscopy oximetry. During the squat exercise, deoxy-Hb continuously increased at RF until failure (10.8 ± 7.0 µmol/L), while at VL, deoxy-Hb was relatively maintained during 25-100% of the number of maximum repetitions (18.0 ± 7.4 µmol/L at volitional failure). During the push-up exercise, a significant increase in deoxy-Hb was observed during exercise from rest at PM and TB. We found a significant increase in oxy-Hb during exercise at PM (28.1 ± 15.8 µmol/L at volitional failure), while at TB, no significant difference was observed from rest (-2.7 ± 13.7 µmol/L at volitional failure). Our findings suggest that the deoxygenation patterns during body-weight squat exercise were heterogeneous within the quadriceps muscles. Moreover, differences in O2 dynamics between the trunk and extremity muscles may be partly explained by convective O2 supply during resistance exercise. However, future studies are needed due to inter-individual differences in skills for body-weight resistance exercise.


Asunto(s)
Músculo Esquelético , Entrenamiento de Fuerza , Humanos , Masculino , Músculo Esquelético/metabolismo , Músculo Esquelético/fisiología , Adulto Joven , Adulto , Oxígeno/metabolismo , Ejercicio Físico/fisiología , Consumo de Oxígeno/fisiología , Hemoglobinas/metabolismo , Movimiento/fisiología , Peso Corporal , Espectroscopía Infrarroja Corta , Oxihemoglobinas/metabolismo , Oximetría/métodos
20.
Skeletal Radiol ; 2024 Sep 16.
Artículo en Inglés | MEDLINE | ID: mdl-39284928

RESUMEN

The clinical significance of osteoporosis lies in the occurrence of fragility fractures (FFx), and the most relevant fracture site is the hip. The T-score is defined as follows: (BMDpatient-BMDyoung adult mean)/SDyoung adult population, where BMD is bone mineral density and SD is the standard deviation. When the femoral neck (FN) is measured in adult Caucasian women, a cutpoint value of patient BMD of 2.5 SD below the young adult mean BMD results in a prevalence the same as the lifetime risk of hip FFx for Caucasian women. The FN T-score criterion for classifying osteoporosis in older Caucasian men has been provisionally recommended to be - 2.5, but debates remain. Based on a systematic literature review, we noted that older men suffer from hip FFx at a FN T-score approximately 0.5-0.6 higher than older women. While the mean hip FFx FN T-score of around - 2.9 for women lies below - 2.5, the mean hip FF FN T-score of around - 2.33 for men lies above - 2.5. This is likely associated with that older male populations have a higher mean T-score than older female populations. We propose a new category of low BMD status, osteofrailia, for older Caucasian men with T-score ≤ - 2 (T-score ≤ - 2.1 for older Chinese men) who are likely to suffer from hip FFx. The group with T-score ≤ - 2 for older Caucasian men is comparable in prevalence to the group with T-score ≤ - 2.5 for older Caucasian women. However, older men in such category on average have only half the FFx risk as that of older women with osteoporotic T-score.

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