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1.
Risk Anal ; 44(2): 439-458, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37357220

RESUMEN

Floods occur frequently in Romania and throughout the world and are one of the most devastating natural disasters that impact people's lives. Therefore, in order to reduce the potential damages, an accurate identification of surfaces susceptible to flood phenomena is mandatory. In this regard, the quantitative calculation of flood susceptibility has become a very popular practice in the scientific research. With the development of modern computerized methods such as geographic information system and machine learning models, and as a result of the possibility of combining them, the determination of areas susceptible to floods has become increasingly accurate, and the algorithms used are increasingly varied. Some of the most used and highly accurate machine learning algorithms are the decision tree models. Therefore, in the present study focusing on flood susceptibility zonation mapping in the Trotus River basin, the following algorithms were applied: forest by penalizing attribute-weights of evidence (forest-PA-WOE), best first decision tree-WOE, alternating decision tree-WOE, and logistic regression-WOE. The best performant, characterized by a maximum accuracy of 0.981, proved to be forest-PA-WOE, whereas in terms of flood exposure, an area of over 16.22% of the Trotus basin is exposed to high and very high floods susceptibility. The performances applied models in the present work are higher than the models applied in the previous studies in the same study area. Moreover, it should be noted that the accuracy of the models is similar with the accuracies of the decision tree models achieved in the studies focused on other areas across the world. Therefore, we can state that the models applied in the present research can be successfully used in by the researchers in other case studies. The findings of this research may substantially map the flood risk areas and further aid watershed managers in limiting and remediating flood damage in the data-scarce regions. Moreover, the results of this study can be a very useful for the hazard management and planning authorities.

2.
Int J Health Plann Manage ; 39(4): 1081-1096, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38348510

RESUMEN

BACKGROUND: Attention to the healthcare workforce has increased, yet comprehensive information on migrant healthcare workers is missing. This study focuses on migrant healthcare workers' experiences and mobility patterns in the middle of a global health crisis, aiming to explore the capacity for circular migration and support effective and equitable healthcare workforce policy. METHODS: Romanian physicians working in Germany during the COVID-19 pandemic served as an empirical case study. We applied a qualitative explorative approach; interviews (n = 21) were collected from mid of September to early November 2022 and content analysis was performed. RESULTS AND DISCUSSION: Migrant physicians showed strong resilience during the COVID-19 crisis and rarely complained. Commitment to high professional standards and career development were major pull factors towards Germany, while perceptions of limited career choices, nepotism and corruption in Romania caused strong push mechanisms. We identified two major mobility patterns that may support circular migration policies: well-integrated physicians with a wish to give something back to their home country, and mobile cosmopolitan physicians who flexibly balance career opportunities and personal/family interests. Health policy must establish systematic monitoring of the migrant healthcare workforce including actor-centred approaches, support integration in destination countries as well as health system development in sending countries, and invest in evidence-based circular migration policy.


Asunto(s)
COVID-19 , Médicos , Investigación Cualitativa , Migrantes , Humanos , COVID-19/epidemiología , Rumanía , Alemania , Masculino , Femenino , Médicos/psicología , Política de Salud , Adulto , Persona de Mediana Edad , Fuerza Laboral en Salud , SARS-CoV-2 , Personal de Salud/psicología , Pandemias
3.
Int J Mol Sci ; 25(2)2024 Jan 22.
Artículo en Inglés | MEDLINE | ID: mdl-38279325

RESUMEN

In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA alleles at the -A, -B, -C, -DRB1, and -DQB1 loci in a cohort of 130 individuals with severe and extremely severe forms of COVID-19, including 44 individuals who died. We compared these findings to a control group consisting of individuals who had either not been diagnosed with COVID-19 or had experienced mild forms of the disease. Using multivariate logistic regression models, we discovered that the B*27 and B*50 alleles were associated with an increased susceptibility to developing a severe form of COVID-19. The A*33 and C*15 alleles showed potential for offering protection against the disease. Furthermore, we identified two protective alleles (A*03 and DQB1*02) against the development of extremely severe forms of COVID-19. By utilizing score statistics, we established a statistically significant association between haplotypes and disease severity (p = 0.021). In summary, this study provides evidence that HLA genotype plays a role in influencing the clinical outcome of COVID-19 infection.


Asunto(s)
COVID-19 , Predisposición Genética a la Enfermedad , Humanos , Rumanía/epidemiología , Frecuencia de los Genes , Cadenas HLA-DRB1/genética , COVID-19/epidemiología , COVID-19/genética , Genotipo , Haplotipos/genética , Alelos
4.
Environ Monit Assess ; 196(2): 186, 2024 Jan 23.
Artículo en Inglés | MEDLINE | ID: mdl-38253920

RESUMEN

To estimate the radiation hazard due to the natural terrestrial radioactivity, 598 samples of soil covering the entire Romanian territory were collected and analyzed for the distribution of natural radionuclides 40K, 228Ac, and 226Ra. The ultra-low background Slanic-Prahova underground laboratory was used to determine the gamma-ray-specific activity of these radioactive isotopes with an uncertainty between 5 and 20%. All these data permitted to establishing a set of 2D maps illustrating the distribution of specific activity of each radionuclide as well as of the resulting air dose rate, all of them illustrating an heterogeneous distribution, increased values being displaced on the western and south-western territory. Mediated over 598 points, these determinations led to a value of annual effective dose of 0.7 ± 0.15 mSv/y and an external hazard index of 0.46 ± 0.1, both attesting to a radioecologically safe environment for human activity.


Asunto(s)
Monitoreo del Ambiente , Laboratorios , Humanos , Rumanía , Rayos gamma , Radioisótopos
5.
Medicina (Kaunas) ; 60(5)2024 May 08.
Artículo en Inglés | MEDLINE | ID: mdl-38792961

RESUMEN

Background and Objectives: Primary malignant bone tumors are rare lesions, and their complex treatment can lead to functional impairment. It is important to have a postoperative assessment tool for patients' functional outcomes to be evaluated and to consequently adapt future treatments in the pursuit of a continuous improvement of their quality of life. The Musculoskeletal Tumor Society Score (MSTS) is a validated specific system score that is used frequently in the follow-up of these patients. We found no information about a valid translated Romanian version of this score neither for the upper limb nor for the lower limb. We proposed in this study to translate the original version of the MSTS Score into Romanian and to perform validation analysis of the Romanian-language MSTS Score. Materials and Methods: We selected 48 patients who underwent limb-salvage surgery after resection of bone sarcomas. Patients were interrogated twice according to the translated Romanian version of the MSTS Score during their follow-up. The translation was performed according to the recommended guidelines. A total number of 96 questionnaires were valid for statistical analysis. Results: Internal consistency and reliability were good for both sets of questionnaires' analytic measurements, with Cronbach's alpha values of 0.848 (test) and 0.802 (retest). The test-retest evaluation proved to be statistically strong for reproducibility and validity with Spearman's rho = 0.9 (p < 0.01, 95% CI). Conclusions: This study permitted the translation of this score and the validation of psychometric data. Our results showed that the Romanian version of the MSTS is a reliable means of assessment of the functional outcome of patients who received limb-salvage surgery for the upper and lower extremities.


Asunto(s)
Neoplasias Óseas , Humanos , Masculino , Femenino , Rumanía , Neoplasias Óseas/cirugía , Adulto , Encuestas y Cuestionarios , Reproducibilidad de los Resultados , Persona de Mediana Edad , Calidad de Vida , Osteosarcoma/cirugía , Comparación Transcultural , Sarcoma/cirugía , Psicometría/instrumentación , Psicometría/métodos , Traducciones , Adolescente , Anciano
6.
Health Qual Life Outcomes ; 21(1): 80, 2023 Jul 29.
Artículo en Inglés | MEDLINE | ID: mdl-37507760

RESUMEN

BACKGROUND: The majority of patient reported outcome measures (PROMs) don't have population norms in Romania. This is the case with the EQ-5D as well. Therefore, we aimed to estimate population norms for the Romanian versions of the EQ-5D-5L, EQ-5D-3L, their indexes, and the EQ-VAS. METHODS: A cross-sectional survey was conducted in all regions of Romania from November 2018 to November 2019. A three-stage probability sampling procedure stratified by region and settlement size was used to select a representative sample. Interviews were computer-assisted and conducted in respondents' homes by trained interviewers. Health status was assessed with the EQ-5D-5L, the EQ-5D-3L and the EQ VAS. Descriptive statistics were used to estimate population norms by age groups and sex for the EQ-5D-5L, the EQ-5D-3L, their indexes and the EQ VAS. Population norms were weighted using survey weights. Indexes for the EQ-5D questionnaires were estimated using the recently developed Romanian value sets. RESULTS: Data from 1,649 interviews was analysed in the present study. Survey weights were used so that sex and place of residence ratios for the weighted sample matched the Romanian general population distribution. Participants' mean age was 47.4 years (SE = 1.157) and 50.3% of them reported being in good health. The dimension for which people reported the highest number of problems for both questionnaires was the pain/discomfort dimension. Men aged 35 plus reported fewer problems with pain/discomfort than women for both the EQ-5D-5L and EQ-5D-3L. Health decreased with age as shown by the decrease from age group 18-24 to age group 75 plus in the indexes of both questionnaires: from 0.977 (SE = 0.005) to 0.765 (SE = 0.017) for EQ-5D-5L and from 0.981 (SE = 0.005) to 0.784 (SE = 0.019) for EQ-5D-3L. There was 29.9 points drop in the EQ VAS score between the youngest and oldest group. CONCLUSIONS: Population norms for the Romanian versions of the EQ-5D-5L, EQ-5D-3L, their indexes, and the EQ VAS are now available. These can now be used as reference values by healthcare professionals, researchers and decision-makers leading to a further development of health-related quality of life research in Romania.


Asunto(s)
Estado de Salud , Calidad de Vida , Masculino , Humanos , Femenino , Persona de Mediana Edad , Adolescente , Adulto Joven , Adulto , Rumanía , Estudios Transversales , Encuestas y Cuestionarios , Dolor , Psicometría , Reproducibilidad de los Resultados
7.
BMC Psychiatry ; 23(1): 662, 2023 09 08.
Artículo en Inglés | MEDLINE | ID: mdl-37684591

RESUMEN

BACKGROUND: Stigma related to mental illness is increasingly and more effectively addressed. Although more research is being conducted, there is relatively little from low and middle-income countries, with former Soviet bloc countries identified as a particular contributor to this evidence gap. Romania struggles with mental health stigma at many levels. The aim of this review was to bring together all relevant data regarding stigma and discrimination related to mental illness as well as actions to address these problems in Romania in order to prioritise further stigma research and identify priority targets for stigma reduction. METHODS: A systematic literature search was conducted in three online databases and grey literature. After the analysis of full manuscripts, four were excluded based on lack of relevance or incomplete data reporting. Quality assessment was performed for included studies using the Mixed Methods Appraisal Tool (MMAT) and the narrative was synthesized based on the research questions. RESULTS: The review included fifteen studies, the majority having a cross-sectional design. Stigma related to mental illness in Romania, has an impact on help-seeking attitudes and behaviours, workplace environment and social relationships of people with mental health problems. Negative stereotypes are maintained and validated by mass media reports. Significant stigma in healthcare and mental care settings has also been observed. Self-stigma was less frequently reported than public stigma. Despite a few stigma reduction actions, no rigorous evaluation of content, delivery and effectiveness has been conducted and no empirical evidence has been published. CONCLUSIONS: Based on this review, three lines of action are recommended in Romania. Increase research concerning stigma in healthcare and mental care settings and use behavioural outcomes. Develop and deliver evidence-based tailored interventions to reduce stigma in identified priority subgroups of the population and ensure rigorous evaluation and scientific dissemination. Elaborate guidelines for working with community stigma and advocate for structural changes.


Asunto(s)
Trastornos Mentales , Salud Mental , Humanos , Estudios Transversales , Rumanía , Estigma Social
8.
Birth ; 50(1): 205-214, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36408741

RESUMEN

BACKGROUND: Eastern European health system indicators (e.g., number of health workers and care coverage) suggest well-resourced maternity care systems, but maternal health outcomes compare poorly with those in Western Europe. Often, poor maternal health outcomes are linked to inequities in accessing adequate maternal care. This study investigates access-related barriers (availability, appropriateness, affordability, approachability, and acceptability) to maternity care in Romania, Bulgaria, and Moldova. METHODS: This cross-country study (n = 7345) is based on an online survey where women who received maternity care and gave birth in 2015-2018 in Bulgaria (n = 4951), Romania (n = 2018), and Moldova (n = 376) provided information on their experiences with the care received. We used regression analysis to identify factors associated with accessing maternity care across the three countries. RESULTS: Results show high rates of cesarean births (CB) and a low number of antenatal and postnatal care visits. Informal payments and use of personal connections are common practices. Formal and informal out-of-pocket payments create a financial burden for women with health complications. Women who had health complications, those who gave birth by cesarean, and women who gave birth in a public facility and had fewer antenatal check-ups, were more likely to describe facing access-related barriers. CONCLUSIONS: This study identifies several barriers to high-quality maternity care in Romania, Bulgaria and Moldova. More attention should be paid to the appropriateness of care provided to women with complicated pregnancies, to those who have CBs, to women who give birth in public facilities, and to those who receive fewer antenatal care visits.


Asunto(s)
Servicios de Salud Materna , Femenino , Humanos , Embarazo , Bulgaria , Moldavia , Rumanía , Europa (Continente)
9.
Euro Surveill ; 28(35)2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37650907

RESUMEN

Measles cases have recently been increasing in Romania, with 460 confirmed cases by August 2023. From March 2023, measles cases increased, and outbreaks were recorded in Cluj, Bistrita Nasaud, Sibiu and Mures counties. New D8 virus variants were identified, different from the variants detected in Romania before the COVID-19 pandemic. We here provide epidemiological and molecular data on the current increase in measles cases in the context of the measles elimination process in the World Health Organization European Region.


Asunto(s)
COVID-19 , Sarampión , Humanos , Rumanía/epidemiología , COVID-19/epidemiología , Pandemias , Brotes de Enfermedades , Sarampión/epidemiología , Sarampión/prevención & control
10.
Int J Mol Sci ; 24(16)2023 Aug 18.
Artículo en Inglés | MEDLINE | ID: mdl-37629107

RESUMEN

Linguatula serrata (Frölich, 1789) is a widespread parasite known as the tongue worm belonging to the family Linguatulidae. The adult form of the parasite is usually located in the upper respiratory tract of domestic and wild carnivores while the larval forms are located in the visceral organs of intermediate hosts (various herbivorous mammals). Twenty-four European brown hares (Lepus europaeus) were examined in this study, of which two were positive with L. serrata nymphs. The collected nymphs were examined morphologically using electron-microscopic analysis and molecularly by amplification of 18S rRNA and COX1 genes. Lung tissue samples were also collected and histopathological examination was performed. Histopathological examination revealed the following lesions: generalized inflammatory oedema, granulomas with necrosis, calcification and fibrosis in the bronchial tree. The results of molecular sequencing for L. serrata specimens collected from the European brown hares are deposited in GenBank. This study presents the first report on Linguatula serrata nymphs collected from L. europaeus in Romania, using molecular and morphological characterization simultaneously.


Asunto(s)
Gastrópodos , Liebres , Lagomorpha , Pentastomida , Animales , Liebres/genética , Pentastomida/genética , Rumanía , Calcificación Fisiológica , Ninfa
11.
J Environ Manage ; 334: 117513, 2023 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-36821987

RESUMEN

While the analysis of spatio-temporal changes in the net primary productivity (NPP) of forests can provide critical information on carbon cycle and climate change, these ecological trends have remained unclear in many countries worldwide, including Romania. By using complex (satellite, forest and climate) data, many sophisticated (machine learning) algorithms and some widely applied (the Mann-Kendall test and Sen's slope estimator) statistical procedures, this study investigates, for the first time, recent forest NPP trends (1987-2018) that occurred in Romania, in relation to climate change that affected the country over the past decades. Following the modelling, mapping and assessment of NPP dynamics, results showed almost exclusively positive trends for this ecological parameter, which accounts for ∼99% of all forest NPP changes that occurred throughout the country, after 1987. Interestingly, almost three quarters (∼73%) of all NPP increasing trends are statistically significant, which indicates that Romania's forests have recently experienced a large-scale improvement in carbon fluxes and stocks. Investigations of eco-climatic relationships suggest that climate change has partially contributed to these surprising NPP dynamics observed in recent decades. All these findings can provide valuable information for forest management and for many stakeholders and policymakers who operate in the forestry and climate fields in Romania.


Asunto(s)
Agricultura Forestal , Bosques , Rumanía , Ciclo del Carbono , Cambio Climático , Ecosistema , Árboles
12.
Environ Monit Assess ; 195(7): 848, 2023 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-37326743

RESUMEN

To estimate the contribution of Chernobyl 137Cs contamination, in 1993 and especially 2016, its total inventory was determined by gamma-ray high-resolution spectroscopy in 62 and respectively 747 soil samples covering the entire Romanian territory. This permitted to estimate the 137Cs inventory as varying between 0.4 and 187 as well as between 0.2 and 94.2 kBq/m2 for years 1993 and 2016, respectively. By representing the spatial distribution of 137Cs inventory in Voronoi polygons, it was possible to evidence a decrease of the total 137Cs inventory over entire Romanian territory with a factor of about 3 from about 3.6 TBq to less than 1.2 TBq, exceeding in this way the natural decay which suggests that a certain amount of 137Cs was washed out by precipitation and, at a lower extent, was incorporated into plants. At the same time, by evaluating the maximum contribution of 137Cs to the population exposure, in 1993 as well as in 2016, the supplementary annual effective dose did not exceed, in the majority of sampling points the value of 0.2 mSv/year.


Asunto(s)
Accidente Nuclear de Chernóbil , Monitoreo de Radiación , Contaminantes Radiactivos del Suelo , Rumanía , Contaminantes Radiactivos del Suelo/análisis , Radioisótopos de Cesio/análisis
13.
Environ Monit Assess ; 195(12): 1520, 2023 Nov 23.
Artículo en Inglés | MEDLINE | ID: mdl-37994974

RESUMEN

Underwater sea caves form a relatively under-examined habitat type within the marine regions of Europe, although they provide unique physical conditions such as reduced light and wave energy, in addition to reduced temperature amplitude. This study aimed at revealing the characteristics of submerged cavities on the southern Romanian continental shelf where six protected areas exist. We used high-resolution bathymetry data and side-scan sonar imaging to identify limestone outcrops where cavities would be most probable to form and then performed visual observation during SCUBA diving activities. We found that submerged cavities appear in all marine-protected areas and their neighboring unprotected areas from the shore to ~20-m depth mostly in the form of caverns, niches, and overhangs that meet the physical requirements of the habitat type 8330 as defined by the European Commission. We propose that habitat type 8330 should be listed in the Natura 2000 Standard Data Forms of the protected areas where it is missing, and we also propose that some protected areas should be expanded to include important areas with the occurrence of this habitat type. Finally, we note here for the first time the occurrence of Movile-type karst and an associated sulfidic water spring on the southern shore of Lake Techirghiol, similar to the region near Mangalia where it was first described in the literature. Although our finding prompts for a more detailed study, it indicates the existence of an underground ecosystem similar to that from the well-studied Movile Cave, but isolated by a distance of over 20 km.


Asunto(s)
Cuevas , Ecosistema , Rumanía , Monitoreo del Ambiente , Europa (Continente)
14.
J Appl Res Intellect Disabil ; 36(5): 1046-1053, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37191143

RESUMEN

BACKGROUND: Much of the research and program innovation regarding future planning for adults with intellectual disabilities has occurred in countries with well-developed disability service systems. This study explored how family caregivers planned for their adult children's future caregiving needs in Romania, a country with a limited array of disability services. METHOD: In this exploratory qualitative study, we conducted 30 face-to-face interviews with caregivers of adults with intellectual disabilities in Romania. We used thematic analysis to analyse the transcribed and translated interview data. RESULTS: The majority of participants, while believing that future planning was necessary, had not engaged in planning and had no supports for planning. As there were few disability services, the majority of the participants reported that they could not engage in planning, and many avoided thinking about the future. CONCLUSION: Romania and other countries with fewer disability services likely need alternative models of future planning than those that have been developed and tested previously.


Asunto(s)
Hijos Adultos , Discapacidad Intelectual , Adulto , Humanos , Cuidadores , Rumanía , Necesidades y Demandas de Servicios de Salud
15.
Medicina (Kaunas) ; 59(7)2023 Jun 28.
Artículo en Inglés | MEDLINE | ID: mdl-37512029

RESUMEN

Background and Objectives: Legal compliance is influenced by several factors, including individuals' attitudes about when breaking the law may be acceptable or justifiable. The rule orientation scale provides a measurement capable of predicting an individual's offensive behavior, regardless of the legal punishment. The current research is the first that aims to evaluate the construct validity of the translated Romanian version of the rule orientation scale. Materials and Methods: A cross-sectional study was conducted online among Romanian physicians in Dolj County. A 12-item questionnaire previously validated in the United States was used for this study. Results: A total of 69 physicians responded to the survey with a mean age of 38.53 ± 8.28 and an average experience of 10.49 ± 8.27 years. Physicians were prone to adhere to the law and found only a few instances when legal breaches were acceptable. Nonetheless, they deemed it permissible to violate the law when they did not know its content. These attitudes were not affected by respondents' ages, genders, numbers of years in practice, industries, or specialties. The internal consistency of the questionnaire was high (Cronbach's α = 0.925). Conclusions: The rule orientation scale validated in the Romanian language can be used to determine conditions under which individuals find it acceptable to break the law.


Asunto(s)
Lenguaje , Médicos , Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Proyectos Piloto , Reproducibilidad de los Resultados , Estudios Transversales , Rumanía , Encuestas y Cuestionarios , Psicometría
16.
Medicina (Kaunas) ; 59(5)2023 May 17.
Artículo en Inglés | MEDLINE | ID: mdl-37241202

RESUMEN

Background and Objectives: Groin hernia repair surgery (GHRS) is among the most common elective interventions. The aim of this three-year nationwide study on GHRS is to provide a thorough analysis of the impact that the COVID-19 pandemic had on the Romanian Health System in regard to elective procedures. Materials and Methods: 46,795 groin hernia cases obtained between 2019 and 2021 from the DRG database using ICD-10 diagnostic codes. The data were collected from all 261 GHRS performing hospitals nationwide, including 227 public hospitals (PbH) and 34 private hospitals (PvH). The 42 variables taken into account were processed using Microsoft Excel 2021, applying Chi square, F-Test Two-Sample for variances, and Two Sample t-Test. The significance threshold considered was p < 0.001. Results: Of the grand total of cases, 96.2% were inguinal hernias, 86.8% were performed on men, 15.2% were laparoscopic procedures, and 6.88% were in PvH. Overall, due to the pandemic, the total number of GHRS decreased with 44.45% in 2020 and with 29.72% in 2021 compared to pre-pandemic year 2019. April 2020 shows the steepest decrease in GHRS (91 procedures nationwide). In the private sector, there was an opposite trend with increases in the number of cases by 12.21% and a 70.22% in both pandemic years. The mean admission period (MAP) for all procedures was 5.5 days. There was a significant difference between PbH and PvH (5.75 vs. 2.8 days, p < 0.0001). During the pandemic, the MAP in PbH decreased (6.02 in 2019, 5.82 in 2020 and 5.3 in 2021), remaining stable for PvH (2.9 days in 2019, 2.85 days in 2020 and 2.74 days in 2021). Conclusions: The COVID-19 pandemic significantly reduced the overall number of GHRS performed in Romania in 2020 and 2021, compared to 2019. However, the private sector thrived with an actual increase in the number of cases. There was a significant lower MAP in the PvH compared to PbH throughout the three-year period.


Asunto(s)
COVID-19 , Hernia Inguinal , Laparoscopía , Masculino , Humanos , Hernia Inguinal/epidemiología , Hernia Inguinal/cirugía , Pandemias , Rumanía/epidemiología , Herniorrafia/métodos , Ingle/cirugía , COVID-19/epidemiología , Laparoscopía/métodos
17.
Medicina (Kaunas) ; 59(10)2023 Oct 13.
Artículo en Inglés | MEDLINE | ID: mdl-37893540

RESUMEN

Background and Objectives: Despite the vast heterogeneity in the genetic defects causing hemophilia A (HA), large intron inversions represent a major cause of disease, accounting for almost half of the cases of severe HA worldwide. We investigated the intron 22 and intron 1 inversion status in a cohort of Romanian unrelated patients with severe HA. Moreover, we evaluated the role of these inversions as relative risk factors in inhibitor occurrence. Materials and Methods: Inverse shifting-a polymerase chain reaction method was used to detect the presence of intron 22 and intron 1 inversions in 156 Romanian patients with HA. Results: Intron inversion 22 was found in 41.7% of the patients, while intron 1 inversion was detected in 3.2% of the patients. Overall, large intron inversions represented the molecular defect in 44.9% of the studied patients. Our findings are in accord with previously published reports from Eastern Europe countries and with other international studies. The risk of inhibitor development was higher in patients with inversion 1 compared to the patients with HA without any inversion detected. Conclusions: The current study demonstrates the major causative role of large intron inversions in severe HA in Romanian patients. Moreover, our study confirms the contribution of intron 1 inversion in inhibitor development.


Asunto(s)
Hemofilia A , Humanos , Hemofilia A/genética , Factor VIII/genética , Intrones/genética , Rumanía , Inversión Cromosómica/genética
18.
Br J Sociol ; 74(4): 717-732, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37656814

RESUMEN

In spite of the existence of an extensive national and supranational legal framework, European Union (EU) citizens who exercise their right to freedom of movement to work in another Member State face numerous hurdles in accessing social protection. While recent scholarship on street-level bureaucracy and on migration and welfare has shed light on the role of discretion and stereotypes in access to rights, little is known about the processes through which such hurdles are overcome. In this article, we focus on a specific strategy which is the recourse to what we call "welfare brokers". These actors offer assistance to EU migrants to overcome specific cross-border administrative challenges in the area of social protection that derive from their use of the right to freedom of movement. Relying on qualitative data collected with brokers and Romanian migrants working in Germany, the article also demonstrates that welfare brokers attempt to transform the norms, bureaucratic practices and representations that condition access to these entitlements. The article concludes by underlining how the existence of a brokerage industry is a sign of existing inequalities in the exercise of freedom of movement within the EU.


Asunto(s)
Migrantes , Humanos , Unión Europea , Alemania , Etnicidad , Política Pública
19.
High Educ (Dordr) ; : 1-19, 2023 Jan 21.
Artículo en Inglés | MEDLINE | ID: mdl-36713136

RESUMEN

The shift to online instruction in higher education related to the COVID-19 pandemic has raised worldwide concerns about an increase in academic misconduct (cheating and plagiarism). However, data to document any increase is sparse. For this study, we collected survey data from 484 students in 11 universities in the USA, and 410 students in five universities in Romania. The data support the conclusions that (1) cheating on exams increased with the shift to online instruction, but plagiarism and cheating on assignments may not have increased, (2) significant differences between the two countries suggest that intervention planning should avoid assuming that results from one context may generalize to another, and (3) influencing student beliefs about rates of AM among their peers may be a fruitful new route for reducing academic misconduct.

20.
J Hist Behav Sci ; 59(2): 129-147, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36251919

RESUMEN

This paper examines the debates around the "miracle of Maglavit", a shepherd's vision of God that took place in 1935 in Romania and attracted much contemporary popular and intellectual interest. The debates drew in arguments from doctors and theologians, who discussed the psychology of divine revelation and tried to elaborate the implications that such an event could have for the life of the Romanian nation. The paper places these debates in the context of wider contemporary discussions about psychology and religion. I argue that what Maglavit shows is that, in Romania at least, public debates about visionary experience in the 1930s were not only debates about its psychology, but of a psychology thoroughly imbricated with political concerns.


Asunto(s)
Disentimientos y Disputas , Religión , Humanos , Rumanía , Religión y Psicología
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