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Animals exhibit a behavioral response to novel sensory stimuli about which they have no prior knowledge. We have examined the neural and behavioral correlates of novelty and familiarity in the olfactory system of Drosophila. Novel odors elicit strong activity in output neurons (MBONs) of the α'3 compartment of the mushroom body that is rapidly suppressed upon repeated exposure to the same odor. This transition in neural activity upon familiarization requires odor-evoked activity in the dopaminergic neuron innervating this compartment. Moreover, exposure of a fly to novel odors evokes an alerting response that can also be elicited by optogenetic activation of α'3 MBONs. Silencing these MBONs eliminates the alerting behavior. These data suggest that the α'3 compartment plays a causal role in the behavioral response to novel and familiar stimuli as a consequence of dopamine-mediated plasticity at the Kenyon cell-MBONα'3 synapse.
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Drosophila melanogaster/fisiología , Cuerpos Pedunculados/fisiología , Animales , Neuronas Dopaminérgicas/fisiología , Aprendizaje , Memoria , Cuerpos Pedunculados/citología , Odorantes , OlfatoRESUMEN
Learning advances through repetition. A classic paradigm for studying this process is the Hebb repetition effect: Immediate serial recall performance improves for lists presented repeatedly as compared to nonrepeated lists. Learning in the Hebb paradigm has been described as a slow but continuous accumulation of long-term memory traces over repetitions [e.g., Page & Norris, Phil. Trans. R. Soc. B 364, 3737-3753 (2009)]. Furthermore, it has been argued that Hebb repetition learning requires no awareness of the repetition, thereby being an instance of implicit learning [e.g., Guérard et al., Mem. Cogn. 39, 1012-1022 (2011); McKelvie, J. Gen. Psychol. 114, 75-88 (1987)]. While these assumptions match the data from a group-level perspective, another picture emerges when analyzing data on the individual level. We used a Bayesian hierarchical mixture modeling approach to describe individual learning curves. In two preregistered experiments, using a visual and a verbal Hebb repetition task, we demonstrate that 1) individual learning curves show an abrupt onset followed by rapid growth, with a variable time for the onset of learning across individuals, and that 2) learning onset was preceded by, or coincided with, participants becoming aware of the repetition. These results imply that repetition learning is not implicit and that the appearance of a slow and gradual accumulation of knowledge is an artifact of averaging over individual learning curves.
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Memoria a Corto Plazo , Aprendizaje Seriado , Humanos , Teorema de Bayes , Tiempo de Reacción , Curva de AprendizajeRESUMEN
According to the predictive processing framework, perception emerges from the reciprocal exchange of predictions and prediction errors (PEs) between hierarchically organized neural circuits. The nonlemniscal division of the inferior colliculus (IC) is the earliest source of auditory PE signals, but their neuronal generators, properties, and functional relevance have remained mostly undefined. We recorded single-unit mismatch responses to auditory oddball stimulation at different intensities, together with activity evoked by two sequences of alternating tones to control frequency-specific effects. Our results reveal a differential treatment of the unpredictable "many-standards" control and the predictable "cascade" control by lemniscal and nonlemniscal IC neurons that is not present in the auditory thalamus or cortex. Furthermore, we found that frequency response areas of nonlemniscal IC neurons reflect their role in subcortical predictive processing, distinguishing three hierarchical levels: (1) nonlemniscal neurons with sharply tuned receptive fields exhibit mild repetition suppression without signaling PEs, thereby constituting the input level of the local predictive processing circuitry. (2) Neurons with broadly tuned receptive fields form the main, "spectral" PE signaling system, which provides dynamic gain compensation to near-threshold unexpected sounds. This early enhancement of saliency reliant on spectral features was not observed in the auditory thalamus or cortex. (3) Untuned neurons form an accessory, "nonspectral" PE signaling system, which reports all surprising auditory deviances in a robust and consistent manner, resembling nonlemniscal neurons in the auditory cortex. These nonlemniscal IC neurons show unstructured and unstable receptive fields that could result from inhibitory input controlled by corticofugal projections conveying top-down predictions.
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Estimulación Acústica , Percepción Auditiva , Colículos Inferiores , Colículos Inferiores/fisiología , Animales , Estimulación Acústica/métodos , Masculino , Percepción Auditiva/fisiología , Neuronas/fisiología , Femenino , Vías Auditivas/fisiología , Potenciales Evocados Auditivos/fisiología , Macaca mulattaRESUMEN
Repeated exposure to a stimulus results in reduced neural response, or repetition suppression, in brain regions responsible for processing that stimulus. This rapid accommodation to repetition is thought to underlie learning, stimulus selectivity, and strengthening of perceptual expectations. Importantly, reduced sensitivity to repetition has been identified in several neurodevelopmental, learning, and psychiatric disorders, including autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by challenges in social communication and repetitive behaviors and restricted interests. Reduced ability to exploit or learn from repetition in ASD is hypothesized to contribute to sensory hypersensitivities, and parallels several theoretical frameworks claiming that ASD individuals show difficulty using regularities in the environment to facilitate behavior. Using fMRI in autistic and neurotypical human adults (females and males), we assessed the status of repetition suppression across two modalities (vision, audition) and with four stimulus categories (faces, objects, printed words, and spoken words). ASD individuals showed domain-specific reductions in repetition suppression for face stimuli only, but not for objects, printed words, or spoken words. Reduced repetition suppression for faces was associated with greater challenges in social communication in ASD. We also found altered functional connectivity between atypically adapting cortical regions and higher-order face recognition regions, and microstructural differences in related white matter tracts in ASD. These results suggest that fundamental neural mechanisms and system-wide circuits are selectively altered for face processing in ASD and enhance our understanding of how disruptions in the formation of stable face representations may relate to higher-order social communication processes.SIGNIFICANCE STATEMENT A common finding in neuroscience is that repetition results in plasticity in stimulus-specific processing regions, reflecting selectivity and adaptation (repetition suppression [RS]). RS is reduced in several neurodevelopmental and psychiatric conditions including autism spectrum disorder (ASD). Theoretical frameworks of ASD posit that reduced adaptation may contribute to associated challenges in social communication and sensory processing. However, the scope of RS differences in ASD is unknown. We examined RS for multiple categories across visual and auditory domains (faces, objects, printed words, spoken words) in autistic and neurotypical individuals. We found reduced RS in ASD for face stimuli only and altered functional connectivity and white matter microstructure between cortical face-recognition areas. RS magnitude correlated with social communication challenges among autistic individuals.
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Trastorno del Espectro Autista , Trastorno Autístico , Reconocimiento Facial , Masculino , Adulto , Femenino , Humanos , Mapeo Encefálico , Encéfalo , Imagen por Resonancia Magnética/métodosRESUMEN
During goal-directed behavior, humans purportedly form and retrieve so-called event files, conjunctive representations that link context-specific information about stimuli, their associated actions, and the expected action outcomes. The automatic formation, and later retrieval, of such conjunctive representations can substantially facilitate efficient action selection. However, recent behavioral work suggests that these event files may also adversely affect future behavior, especially when action requirements have changed between successive instances of the same task context (e.g., during task switching). Here, we directly tested this hypothesis with a recently developed method for measuring the strength of the neural representations of context-specific stimulus-action conjunctions (i.e., event files). Thirty-five male and female adult humans performed a task switching paradigm while undergoing EEG recordings. Replicating previous behavioral work, we found that changes in action requirements between two spaced repetitions of the same task incurred a significant reaction time cost. By combining multivariate pattern analysis and representational similarity analysis of the EEG recordings with linear mixed-effects modeling of trial-to-trial behavior, we then found that the magnitude of this behavioral cost was directly proportional to the strength of the conjunctive representation formed during the most recent previous exposure to the same task, that is, the most recent event file. This confirms that the formation of conjunctive representations of specific task contexts, stimuli, and actions in the brain can indeed adversely affect future behavior. Moreover, these findings demonstrate the potential of neural decoding of complex task set representations toward the prediction of behavior beyond the current trial.SIGNIFICANCE STATEMENT Understanding how the human brain organizes individual components of complex tasks is paramount for understanding higher-order cognition. During complex tasks, the brain forms conjunctive representations that link individual task features (contexts, stimuli, actions), which aids future performance of the same task. However, this can have adverse effects when the required sequence of actions within a task changes. We decoded conjunctive representations from electroencephalographic recordings during a task that included frequent changes to the rules determining the response. Indeed, stronger initial conjunctive representations predicted significant future response-time costs when task contexts repeated with changed response requirements. Showing that the formation of conjunctive task representations can have negative future effects generates novel insights into complex behavior and cognition, including task switching, planning, and problem solving.
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Encéfalo , Cognición , Adulto , Humanos , Masculino , Femenino , Cognición/fisiología , Tiempo de Reacción/fisiología , Electroencefalografía , Mapeo EncefálicoRESUMEN
A model based on inhibitory coupling has been proposed to explain perceptual oscillations. This 'adapting reciprocal inhibition' model postulates that it is the strength of inhibitory coupling that determines the fate of competition between percepts. Here, we used an fMRI-based adaptation technique to reveal the influence of neighboring neuronal populations, such as reciprocal inhibition, in motion-selective hMT+/V5. If reciprocal inhibition exists in this region, the following predictions should hold: 1. stimulus-driven response would not simply decrease, as predicted by simple repetition-suppression of neuronal populations, but instead, increase due to the activity from adjacent populations; 2. perceptual decision involving competing representations, should reflect decreased reciprocal inhibition by adaptation; 3. neural activity for the competing percept should also later on increase upon adaptation. Our results confirm these three predictions, showing that a model of perceptual decision based on adapting reciprocal inhibition holds true. Finally, they also show that the net effect of the well-known repetition suppression phenomenon can be reversed by this mechanism.
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Inhibición Psicológica , Neuronas , HumanosRESUMEN
The flexibility of the motor system to adjust a planned action before or during the execution of the movement in response to sensory information is critical for preventing errors in motor control. As individuals age, this function declines, leading to an increased incidence of motor errors. Although sensory processing and cognitive decline are known contributors to this impairment, here, we test the hypothesis that repetition of context-specific planned actions interferes with the adjustment of feedforward motor commands. Younger and older participants were instructed to grasp and lift a T-shaped object with a concealed, off-sided center of mass and minimize its roll through anticipatory force control, relying predominantly on predictive model-driven planning (i.e., sensorimotor memories) developed through repeated lifts. We selectively manipulate the number of trial repeats with the center of mass on one side before switching it to the other side of the T-shaped object. The results showed that increasing the number of repetitions improved performance in manipulating an object with a given center of mass but led to increased errors when the object's center of mass was switched. This deleterious effect of repetition on feedforward motor adjustment was observed in younger and older adults. Critically, we show these effects on an internal model-driven motor planning task that relies predominantly on sensorimotor memory, with no differences in sensory inputs from the repetition manipulation. The findings indicate that feedforward motor adjustments are hampered by repetitive stereotyped planning and execution of motor behavior.NEW & NOTEWORTHY Adjusting planned actions in response to sensory stimuli degrades with age contributing to increased incidence of errors ranging from clumsy spills to catastrophic falls. Multiple factors likely contribute to age-related motor inflexibility, including sensory- and cognition-supporting system declines. Here, we present compelling evidence for repetition to disrupt feedforward adjusting of motor commands in younger and older adults, which suggests increases in stereotypy as a deleterious potentiator of motor control errors.
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Envejecimiento , Desempeño Psicomotor , Humanos , Masculino , Anciano , Femenino , Adulto , Desempeño Psicomotor/fisiología , Adulto Joven , Envejecimiento/fisiología , Persona de Mediana Edad , Fuerza de la Mano/fisiología , Actividad Motora/fisiologíaRESUMEN
BACKGROUND: Suicide is one of the main external causes of death worldwide. People who have already attempted suicide are at high risk of new suicidal behavior. However, there is a lack of information on the risk factors that facilitate the appearance of reattempts. The aim of this study was to calculate the risk of suicide reattempt in the presence of suicidal history and psychosocial risk factors and to estimate the effect of each individual risk factor. METHODS: This systematic review and meta-analysis were conducted following the PRISMA-2020 guidelines. Studies on suicide reattempt that measured risk factors were searched from inception to 2022. The risk factors studied were those directly related to suicide history: history of suicide prior to the index attempt, and those that mediate the transition from suicidal ideation to attempt (alcohol or drug misuse, impulsivity, trauma, and non-suicidal self-injury). RESULTS: The initial search resulted in 11 905 articles. Of these, 34 articles were selected for this meta-analysis, jointly presenting 52 different effect sizes. The pooled effect size across the risk factors was significant (OR 2.16). Reattempt risk may be increased in presence of any of the following risk factors: previous history, active suicidal ideation, trauma, alcohol misuse, and drug misuse. However, impulsivity, and non-suicidal self-injury did not show a significant effect on reattempt. CONCLUSION: Most of the risk factors traditionally associated with suicide are also relevant when talking about suicide reattempts. Knowing the traits that define reattempters can help develop better preventive and intervention plans.
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In the human electroencephalogram (EEG), induced oscillatory responses in various frequency bands are regarded as valuable indices to examine the neural mechanisms underlying human memory. While the advent of virtual reality (VR) drives the investigation of mnemonic processing under more lifelike settings, the joint application of VR and EEG methods is still in its infancy (e.g., due to technical limitations impeding the signal acquisition). The objective of the present EEG study was twofold. First, we examined whether the investigation of induced oscillations under VR conditions yields equivalent results compared to standard paradigms. Second, we aimed at obtaining further insights into basic memory-related brain mechanisms in VR. To these ends, we relied on a standard implicit memory design, namely repetition priming, for which the to-be-expected effects are well-documented for conventional studies. Congruently, we replicated a suppression of the evoked potential after stimulus onset. Regarding the induced responses, we observed a modulation of induced alphaband in response to a repeated stimulus. Importantly, our results revealed a repetition-related suppression of the high-frequency induced gammaband response (>30 Hz), indicating the sharpening of a cortical object representation fostering behavioral priming effects. Noteworthy, the analysis of the induced gammaband responses required a number of measures to minimize the influence of external and internal sources of artefacts (i.e., the electrical shielding of the technical equipment and the control for miniature eye movements). In conclusion, joint VR-EEG studies with a particular focus on induced oscillatory responses offer a promising advanced understanding of mnemonic processing under lifelike conditions.
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Memoria Implícita , Realidad Virtual , Humanos , Memoria Implícita/fisiología , Encéfalo/fisiología , Electroencefalografía/métodos , Potenciales Evocados/fisiologíaRESUMEN
Water treatment is one of the most important issues for all walks of life around the world. The unique advantages of the solid-state power electronic pulses in water treatment make it attractive and promising in practical applications. The output voltage, rising time, repetition rate, and peak power of output pulses have a significant impact on the effectiveness of water treatment. Especially in pulse electric field treatment and pulse discharge treatment, the pulse with fast rising time achieves the advantage of generating plasma without corona, which can avoid water heating effect and greatly improve the efficiency of the pulse generator. High repetition rate can significantly reduce the peak power requirement of the pulse in water treatment application, making the equipment smaller and improving the power density. Therefore, the study developed a high-voltage high frequency sub-nanosecond pulse power generator (PPG) system for wastewater treatment. It adopts SiC DSRD (Drift Step Recovery Diode) solid-state switches and realize modular design, which can achieve high performance and can be flexible expanded according to the requirements of water treatment capacity. Finally, an expandable high-voltage PPG for water treatment is built. The output parameters of the PPG include output pulse voltage range from 1 to 5.28 kV, rise time <600 ps (20%-90%), repetition up to 1 MHz. The experiment results of PPG application for pulse discharge water treatment is presented. The results indicate that the proposed generator achieves high-efficiency degradation of 4-Chlorophenol (4-CP), which is one of the most common chlorophenol compounds in wastewater. From experiment, the homemade system can degrade 450 mL waste water containing 500 mg/L 4-CP in 35 min, with a degradation rate of 98%. Thereby, the requirement for electric field intensity decreased. Through the further quantitative analysis, the impact of frequency, voltage, and electrode spacing on the degradation effect of 4-CP is confirmed.
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Purificación del Agua , Purificación del Agua/métodos , Purificación del Agua/instrumentación , Contaminantes Químicos del Agua/análisis , Aguas Residuales/química , Eliminación de Residuos Líquidos/métodos , Eliminación de Residuos Líquidos/instrumentación , ElectricidadRESUMEN
The learning process encompasses exploration and exploitation phases. While reinforcement learning models have revealed functional and neuroscientific distinctions between these phases, knowledge regarding how they affect visual attention while observing the external environment is limited. This study sought to elucidate the interplay between these learning phases and visual attention allocation using visual adjustment tasks combined with a two-armed bandit problem tailored to detect serial effects only when attention is dispersed across both arms. Per our findings, human participants exhibited a distinct serial effect only during the exploration phase, suggesting enhanced attention to the visual stimulus associated with the non-target arm. Remarkably, although rewards did not motivate attention dispersion in our task, during the exploration phase, individuals engaged in active observation and searched for targets to observe. This behavior highlights a unique information-seeking process in exploration that is distinct from exploitation.
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Atención , Recompensa , Percepción Visual , Humanos , Atención/fisiología , Adulto , Adulto Joven , Masculino , Percepción Visual/fisiología , Femenino , Desempeño Psicomotor/fisiología , Conducta Exploratoria/fisiologíaRESUMEN
Fluency theories predict higher truth judgments for easily processed statements. We investigated two factors relevant for processing fluency: repetition and syntactic complexity. In three online experiments, we manipulated syntactic complexity by creating simple and complex versions of trivia statements. Experiments 1 and 2 replicated the repetition-based truth effect. However, syntactic complexity did not affect truth judgments although complex statements were processed slower than simple statements. This null effect is surprising given that both studies had high statistical power and varied in the relative salience of syntactic complexity. Experiment 3 provides a preregistered test of the discounting explanation by using improved trivia statements of equal length and by manipulating the salience of complexity in a randomized design. As predicted by fluency theories, simple statements were more likely judged as true than complex ones, while this effect was small and not moderated by the salience of complexity.
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Juicio , Publicación de Preinscripción , HumanosRESUMEN
A form of repetition blindness in visually unimpaired individuals was found for objects presented during saccades. Observers were asked to draw their percepts after making saccades across an LED strip that "painted" an image on their retinas by presenting sequential columns of a bitmap at a speed to match a 30-degree saccade. During experimental trials, repetitions of a single letter (either "A," "X," "H," or "V") were presented across saccades. Although an average of six letters were presented across each saccade, observers typically indicated perceiving only a single instance of the letter in their drawings. This inability to perceive multiple instances of a letter was not due to a limited region of attentional processing, as it only attained for multiple instances along the axis of the saccade-horizontal saccades did not affect perception of multiple letters along the vertical axis. This effect is likely due to selective suppression of visual areas during saccades.
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Movimientos Sacádicos , Humanos , Movimientos Sacádicos/fisiología , Adulto , Adulto Joven , Masculino , Femenino , Atención/fisiología , Percepción Visual/fisiología , Reconocimiento Visual de Modelos/fisiologíaRESUMEN
People not only judge repeatedly perceived information as more likely being true (the so-called truth effect) they also tend to be more confident after judging the validity of repeated information. These phenomena are assumed to be caused by a higher subjective feeling of ease (i.e., fluency) when processing repeated (vs. new) information. Based on the suggestion that a higher number of coherent mental activations is promoting a fluency experience, we argue that besides repetition an already existing information network, that is (nonspecific) prior knowledge, can enhance fluency. Following this argumentation, information repetition as well as the act of judging incoming information as being true (vs. false) should feed into subjective confidence - independently of the factual truth (when judging under uncertainty). To test this, we reanalyzed two published data sets and conducted a new study. In total, participants (N = 247) gave 29,490 truth judgments and corresponding ratings of subjective confidence while attending two judgement phases (i.e., 10 min and 1 week after the exposure phase in each experiment). Results showed that (a) repetition (in 3 of 3 data sets) and (b) impressions of truth (in 2 of 3 data sets) were systematically related to higher subjective confidence. Moreover, we found (c) a significant positive interaction between repetition and impressions of truth after both intervals in all data sets. Our analyses further underline the moderating effect of time: Influences of repetition significantly decreased with increasing time interval. Notably, the factual truth did not systematically affect any of the above reported effects.
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Juicio , Humanos , Juicio/fisiología , Femenino , Masculino , Adulto , Adulto Joven , Incertidumbre , AdolescenteRESUMEN
Many studies have shown that compared to the restudy condition (RS), retrieval practice (RP) enhances the long-retention memory of retrieved items (i.e., the testing effect), and facilitates later memory of non-retrieved but related items (i.e., the transfer effect). However, previous studies have usually used repeated study and repeated testing, which are included in study-testing cycles. Therefore, it is unclear to what extent the factors of repeated study and repeated testing influence testing and transfer effects over time. In this study, participants studied sentences that described various episodes, then tested a half subset of the original sentences under three conditions (RP, RS, control). After retention intervals of 10 min, 1 day and 7 days, they recalled all of the information in the sentences. The results showed that the testing effect was enhanced by repeated study or repeated testing, while the transfer effect occurred only after both repeated study and repeated testing. Furthermore, repeated study or repeated testing slowed down the forgetting of retrieved items, while the forgetting of non-retrieved items occurred after both repeated study and repeated testing. The testing effect increased over time, but the transfer effect remained relatively stable over time. These results clarified different roles of multiple study repetitions and testing opportunities in the testing effect and the transfer effect, and suggest that the repeated retrieval could be combined with repeated study to optimally promote long-term retention of the memory of tested and non-tested items.
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Memoria , Recuerdo Mental , Humanos , LenguajeRESUMEN
Inhibition during task switching is assumed to be indexed by n - 2 repetition costs-that is, performance costs when the task in the current trial equals the task in trial n - 2 (sequences of type ABA) compared with two consecutive switches to another task each (sequences CBA). The present study examined effects of a short-term reduction of the number of candidate tasks on these costs. For this purpose, a variant of the task switching paradigm was used in which in half of the trials, a precue that preceded the task cue allowed for a short-term reduction of the number of candidate tasks. In Experiment 1, one out of three tasks could be excluded. In Experiment 2, one or two out of four tasks could be excluded. Experiment 3 served as control condition using the standard cueing paradigm. Significant n - 2 repetition costs were present with three candidate tasks. In contrast, no costs were visible when the number of candidate tasks was reduced to two. This result is interpreted in terms of a task selection mechanism based on antagonistic constraints among task representations, which operates on a rather superficial level when switching among only two tasks, thereby reducing the need for inhibition.
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Señales (Psicología) , Inhibición Psicológica , Humanos , Tiempo de Reacción/fisiología , Desempeño Psicomotor/fisiologíaRESUMEN
Studies on the SPoARC effect have shown that serial information is spatially processed in working memory. However, it remains unknown whether these spatial-positional associations are durable or only temporary. This study aimed at investigating whether spatialization would persist when a sequence presented repeatedly is expected to be chunked. If chunked, the items could be unified spatially and their spatialization could vanish. Thirty-seven participants performed a spatialization task which was remotely inspired by the Hebb repetition paradigm. A sequence of four stimuli presented individually in the middle of a computer screen was repeated throughout the task. After each sequence, participants had to decide whether a probe belonged to the series using two lateralized response keys. The results showed no spatialization for these repetitive sequences, on average. Moreover, further analysis revealed that the effect was detectable at the beginning of the task, suggesting that the more the sequence was repeated, the less participants spatialized information from left to right. These findings show that associations created in working memory between items and space can vanish in repeated sequences: we discuss the idea that working memory progressively saves on spatialization once a sequence is chunked in long-term memory.
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Recognition of speech in noise is facilitated when spoken sentences are repeated a few minutes later, but the levels of representation involved in this effect have not been specified. Three experiments tested whether the effect would transfer across modalities and languages. In Experiment 1, participants listened to sets of high- and low-constraint sentences and read other sets in an encoding phase. At test, these sentences and new sentences were presented in noise, and participants attempted to report the final word of each sentence. Recognition was more accurate for repeated than for new sentences in both modalities. Experiment 2 was identical except for the implementation of an articulatory suppression task at encoding to reduce phonological recoding during reading. The cross-modal repetition priming effect persisted but was weaker than when the modality was the same at encoding and test. Experiment 3 showed that the repetition priming effect did not transfer across languages in bilinguals. Taken together, the results indicate that the facilitated recognition of repeated speech is based on a combination of modality-specific processes at the phonological word form level and modality-general processes at the lemma level of lexical representation, but the semantic level of representation is not involved.
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Percepción del Habla , Habla , Humanos , Memoria Implícita , Lenguaje , SemánticaRESUMEN
It is now well established that general information processing causes the activation of memories in the autobiographical memory system, and these memories on occasion emerge as involuntary autobiographical memories. This priming phenomenon has been dubbed semantic-to-autobiographical memory priming, and our goal in the current study was to examine the effects of cue/prime repetition on the production of involuntary autobiographical memories that were primed with semantic stimuli. In three experiments, participants were primed with words (e.g., cat), and then they were given an involuntary memory task (the vigilance task), which contained cues related to the primed stimuli. In Experiment 1, the cues were phrases containing the primes (e.g., getting a cat), which were presented one or five times. In Experiment 2, the cues were also phrases containing the primes (e.g., getting a cat), but they changed their context (e.g., feeding a cat), every time they repeated in the five-presentation condition. Experiment 3 also presented the cues one or five times, but the cues were replicas of the primes (e.g., cat). Consistent with predictions, greater priming was found in the five-presentation cue conditions in all three experiments, and Experiment 3 failed to find priming in the one-presentation cue condition, also consistent with predictions. We explain the findings in terms of semantic-to-autobiographical memory priming theory, and also argue that the results help explain the production of involuntary memories in everyday life.
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OBJECTIVES: To investigate the appropriate combination of pulse length (PL) and pulse repetition frequency (PRF) when performing ultrasound stimulated microbubble (USMB) to enhance doxorubicin (DOX) delivery to tumors. METHODS: A total of 48 tumor-bearing mice were divided into four groups, namely groups A-D. The mice in groups B-D were treated with chemotherapy and USMB treatment with different combinations of PL and PRF, and group A was control. Contrast-enhanced ultrasound imaging was conducted to analyze tumor blood perfusion. Fluorescence microscopy and high-performance liquid chromatography were used to qualitatively and quantitatively analyse DOX release. The structural changes of tumors were observed under light microscope and transmission electron microscope. Furthermore, another 24 tumor-bearing mice were treated with sonochemotherapy and some related inflammatory factors were measured to explore the underlying mechanism. RESULTS: With PL of three cycles and PRF of 2 kHz, the tumor perfusion area ratio increased by 26.67%, and the DOX concentration was 4.69 times higher than the control (P < .001). With PL of 34.5 cycles and PRF of 200 Hz, the tumor perfusion area ratio decreased by 12.7% and DOX did not exhibit increased extravasation compared with the control. Microvascular rupture and hemorrhage were observed after long PL and low PRF treatment. While vasodilation and higher levels of some vasodilator inflammatory factors were found after treatment with short PL and high PRF. CONCLUSIONS: USMB treatment using short PL and high PRF could enhance tumor blood perfusion and increase DOX delivery, whereas long PL and low PRF could not serve the same purpose.