RESUMEN
Corn oil, sesame oil, and 10% ethanol in corn oil are commonly used as dosing vehicles in toxicology studies. Since these vegetable oils contain bioactive compounds, it is important for toxicology studies to characterize the toxicities of the dosing vehicles themselves. It has been recently proposed that the width of the genital tubercle (GT), the dorsal-ventral length (D-V length) of the GT, and urethral tube closure in mouse fetuses can be used as novel markers for monitoring sexual development in mice. However, how these parameters are influenced by the dosing vehicles themselves remains unclear. Therefore, we evaluated the effects of corn oil, sesame oil, and 10% ethanol in corn oil on GT width, D-V length, and GT morphology in ICR mice. Our results showed that all three vehicles influenced GT width and D-V length, but not GT morphology, suggesting that the effects of dosing vehicles themselves might need to be considered when GT width or D-V length is used as a parameter to evaluate the effects of chemicals on GT development.
Asunto(s)
Etanol/efectos adversos , Desarrollo Fetal/efectos de los fármacos , Intercambio Materno-Fetal , Vehículos Farmacéuticos/efectos adversos , Aceites de Plantas/efectos adversos , Desarrollo Sexual/efectos de los fármacos , Animales , Aceite de Maíz/administración & dosificación , Aceite de Maíz/efectos adversos , Etanol/administración & dosificación , Femenino , Peso Fetal/efectos de los fármacos , Inyecciones Subcutáneas , Masculino , Ratones Endogámicos ICR , Vehículos Farmacéuticos/administración & dosificación , Placentación/efectos de los fármacos , Aceites de Plantas/administración & dosificación , Embarazo , Distribución Aleatoria , Reproducibilidad de los Resultados , Aceite de Sésamo/administración & dosificación , Aceite de Sésamo/efectos adversos , Caracteres Sexuales , Procesos de Determinación del Sexo/efectos de los fármacos , Pruebas de Toxicidad/métodos , Anomalías Urogenitales/inducido químicamente , Anomalías Urogenitales/embriología , Anomalías Urogenitales/patologíaRESUMEN
BACKGROUND: Exogenous lipoid pneumonia is a rare disease caused by aspiration or inhalation of oily substances. CASE PRESENTATION: A 66-year-old male with dry cough (Case 1) and a 38-year-old female with shortness of breath (Case 2) demonstrated ground-glass opacities on chest computed tomography and were diagnosed with lipoid pneumonia based on the confirmation of lipid-laden alveolar macrophages. Both patients habitually performed sesame oil pulling via nasal or mouth washing for several months prior to the diagnosis. CONCLUSION: Steroid therapy and bronchoalveolar lavage resulted in improvement in Case 1, and no intensive therapy was required for Case 2. Sesame oil pulling has been rarely been reported to cause lipoid pneumonia.
Asunto(s)
Exposición por Inhalación , Neumonía Lipoidea/diagnóstico , Neumonía Lipoidea/terapia , Aceite de Sésamo/efectos adversos , Adulto , Anciano , Lavado Broncoalveolar , Femenino , Humanos , Masculino , Prednisolona/administración & dosificación , Tomografía Computarizada por Rayos XRESUMEN
The present study aimed to build a DHEA-induced polycystic ovary syndrome (PCOS) rat model to evaluate the potential mechanism of DHEA-induced AMH rise in these rat ovarian tissues. A total of 36 female 3-week-old rats were allocated into two groups at random. The control group received merely the same amount of sesame oil for 20 days while the experimental group received 0.2 mL of sesame oil Plus DHEA 6 mg/100 g daily. Both groups' vaginal opening times were noted, and vaginal smears were taken. By using RT-qPCR and Western blot, the mRNA and protein expression of AMH, GATA4, SF1, and SOX9 in the ovarian tissues of the two groups was investigated.The rats in the experimental group appeared to have obvious disorders of the estrus cycle, as evidenced by the ratio of estrus being significantly higher than that in the control group (P < 0.05); HE staining revealed that the ovarian volume, follicular vacuoles, and follicular lumen of the rats in the experimental group increased significantly.The ELISA results revealed that T and AMH in the experimental group were higher than those in the control group at day 15 and 20. AMHãGATA4 and SF1 mRNA and protein expression were higher in the experimental group than in the control group on day 15 and 20 (P < 0.05). On day 20, the experimental group outperformed the control group (P < 0.05). In the DHEA-induced PCOS rat model, androgen may have enhanced AMH expression via increasing the expression of genes associated to the AMH promoter binding site (GATA4, SF1, SOX9).
Asunto(s)
Síndrome del Ovario Poliquístico , Humanos , Ratas , Femenino , Animales , Síndrome del Ovario Poliquístico/inducido químicamente , Síndrome del Ovario Poliquístico/metabolismo , Aceite de Sésamo/efectos adversos , Deshidroepiandrosterona/farmacología , ARN Mensajero , Hormona Antimülleriana/genéticaRESUMEN
Intramuscular oil injections generating slowly degrading oil-based depots represent a controversial subject in bodybuilding and fitness. However they seem to be commonly reported in a large number of non-medical reports, movies and application protocols for 'site-injections'. Surprisingly the impact of long-term (ab)use on the musculature as well as potential side-effects compromising health and sports ability are lacking in the medical literature. We present the case of a 40 year old male semi-professional bodybuilder with systemic infection and painful reddened swellings of the right upper arm forcing him to discontinue weightlifting. Over the last 8 years he daily self-injected sterilized sesame seed oil at numerous intramuscular locations for the purpose of massive muscle building. Whole body MRI showed more than 100 intramuscular rather than subcutaneous oil cysts and loss of normal muscle anatomy. 2-step septic surgery of the right upper arm revealed pus-filled cystic scar tissue with the near-complete absence of normal muscle. MRI 1 year later revealed the absence of relevant muscle regeneration. Persistent pain and inability to perform normal weight training were evident for at least 3 years post-surgery. This alarming finding indicating irreversible muscle mutilation may hopefully discourage people interested in bodybuilding and fitness from oil-injections. The impact of such chronic tissue stress on other diseases like malignancy remains to be determined.
Asunto(s)
Músculo Esquelético/efectos de los fármacos , Músculo Esquelético/lesiones , Aceite de Sésamo/efectos adversos , Levantamiento de Peso , Absceso/etiología , Absceso/patología , Absceso/cirugía , Adulto , Brazo/diagnóstico por imagen , Brazo/patología , Brazo/cirugía , Quistes/etiología , Quistes/patología , Quistes/cirugía , Edema/etiología , Edema/patología , Edema/cirugía , Granuloma/etiología , Granuloma/patología , Granuloma/cirugía , Humanos , Infecciones/etiología , Infecciones/patología , Infecciones/cirugía , Inyecciones Intramusculares/efectos adversos , Imagen por Resonancia Magnética , Masculino , Músculo Esquelético/anatomía & histología , Músculo Esquelético/patología , Músculo Esquelético/cirugía , Dolor/etiología , Dolor/patología , Dolor/cirugía , Radiografía , Aceite de Sésamo/administración & dosificación , Resultado del TratamientoRESUMEN
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world. There is strong evidence that dyslipidemia and other cardio-metabolic disorders are highly prevalent in patients with NAFLD. This trial aimed at examining the effect of sesame oil (SO) in the context of a weight loss program on lipid profile, blood pressure, and anthropometric indices in women with NAFLD. METHODS: This randomized, double-blind, controlled trial was carried out on 60 women with NAFLD. Subjects were randomly assigned to the SO group (n = 30) and sunflower oil (SFO) group (n = 30), each person consuming 30 g of oil per day for 12 weeks. All the participants received a hypocaloric diet (- 500 kcal/day) during the study. Lipid profile, blood pressure, and anthropometric indices were assessed at pre- and post-intervention phases. RESULTS: In total, 53 participants completed the study. Following 12 weeks of intervention, anthropometric indices (p < 0.001) and systolic blood pressure (SBP) (p < 0.05) were significantly decreased in both groups and diastolic blood pressure (DBP) was significantly decreased in So group (p = 0.03). There was no significant change in lipid profile in both groups (p > 0.05). After adjusting for confounders, DBP (p = 0.031) and total cholesterol (TC) divided by high-density lipoprotein cholesterol (HDL-C) (p = 0.039) in the SO group were significantly reduced compared to the SFO group (p < 0.05). CONCLUSIONS: The present clinical trial revealed that SO and SFO may not differently affect anthropometric indices, SBP, and lipid profile except for TC/HDL-C. In addition, SO may be effective in improvement of DBP and TC/HDL-C compared to the SFO group. TRIAL REGISTRATION: Ethical approval of this trial was obtained at Isfahan University of Medical Sciences with the reference number of IR.MUI. RESEARCH: REC.1399.548 ( https://ethics. RESEARCH: ac.ir/ProposalCertificateEn.php?id=158942&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true ), and it was registered before the start of the patient recruitment on December 12th, 2020 in the Iranian Registry of Clinical Trials (IRCT) with the registration number of IRCT20140208016529N6 .
Asunto(s)
Enfermedad del Hígado Graso no Alcohólico , Presión Sanguínea , HDL-Colesterol , Dieta Reductora , Método Doble Ciego , Femenino , Humanos , Irán , Enfermedad del Hígado Graso no Alcohólico/diagnóstico , Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico , Obesidad , Aceite de Sésamo/efectos adversos , Aceite de Girasol/farmacología , Aceite de Girasol/uso terapéuticoRESUMEN
Sesamum indicum (sesame) seed oil and related cosmetic ingredients are derived from Sesamum indicum. Sesamum indicum (sesame) seed oil, sesamum indicum (sesame) oil unsaponifiables, and hydrogenated sesame seed oil function as conditioning agents. Sodium sesameseedate functions as a cleansing agent, emulsifying agent, and a nonaqueous viscosity increasing agent. These ingredients are neither skin irritants, sensitizers, teratogens, nor carcinogens at exposures that would result from cosmetic use. Both animal and human data relevant to the cosmetic use of these ingredients were reviewed. The CIR Expert Panel concluded that these ingredients are safe in the present practices of use and concentration as described in this safety assessment.
Asunto(s)
Cosméticos/efectos adversos , Cosméticos/química , Aceite de Sésamo/efectos adversos , Aceite de Sésamo/química , Sesamum/química , Jabones/química , Animales , Seguridad de Productos para el Consumidor , Aditivos Alimentarios/efectos adversos , Aditivos Alimentarios/química , Humanos , Hidrogenación , Estructura Molecular , Pruebas de ToxicidadRESUMEN
OBJECTIVES: As a rose geranium in sesame oil spray product has been anecdotally noted to improve nasal vestibulitis symptoms, this study was designed to assess whether patients with nasal vestibulitis associated with cancer-directed therapy experienced symptomatic improvements from it. METHODS: Patients with breast cancer, prescribed rose geranium nasal spray, were identified by looking at pharmacy records and patient diagnosis at Mayo Clinic Rochester. Patient medical information, as well as documentation of symptoms, were gleaned from medical charts. Questionnaires were sent to patients regarding their experiences. RESULTS: Of the 40 patients with breast cancer who were prescribed rose geranium nasal spray, 100% were receiving cancer-directed therapy: 58 % were receiving taxane chemotherapy; others received a variety of cytotoxic and targeted therapy treatments. Twenty patients who had used the spray product returned surveys. Patient-reported nasal symptoms included bleeding (90%), dryness (86%), pain (81%), scabbing (67%) and sores (52%); patients consistently reported symptoms at a higher proportion than did healthcare providers. All patients who used the rose geranium nasal spray reported symptomatic benefit; one reported a little benefit, 11 (55%) reported moderate benefit and eight (40%) reported dramatic or complete resolution of symptoms. The therapy was well tolerated in most patients. CONCLUSIONS: Rose geranium in sesame oil nasal spray appears to improve patient-reported nasal symptoms associated with cancer-directed therapy.
Asunto(s)
Geranium , Enfermedades Nasales/tratamiento farmacológico , Aceite de Sésamo/uso terapéutico , Administración Intranasal , Adulto , Aerosoles , Anciano , Antineoplásicos/efectos adversos , Antineoplásicos/uso terapéutico , Neoplasias de la Mama/complicaciones , Neoplasias de la Mama/tratamiento farmacológico , Método Doble Ciego , Femenino , Geranium/química , Humanos , Persona de Mediana Edad , Rociadores Nasales , Enfermedades Nasales/inducido químicamente , Aceite de Sésamo/administración & dosificación , Aceite de Sésamo/efectos adversos , Resultado del TratamientoRESUMEN
This study examined the dietary effects of enzymatically modified sesame oil with caprylic acid (structured lipids, SL) and phytosteryl esters (PE) on blood lipid profiles and cardiovascular parameters of spontaneously hypertensive rats (SHR) fed high-fat and high-cholesterol (HFHC) diets. The dietary groups were: normal diet (control), sesame oil (SO), SL, SO fortified with PE (SOP), and SL fortified with PE (SLP). After 9 weeks of feeding, the body weights, liver weights, and liver weight/body weight ratios in all HFHC-fed groups were higher than controls. Plasma total and LDL cholesterol levels in all HFHC-fed groups were similar to one another but higher than those in controls. Plasma HDL cholesterol levels in rats fed SOP and SLP were higher than those in controls or rats fed SO and SL. Plasma HDL/total cholesterol ratios in rats fed SOP and SLP were similar to those in controls and were higher than those in rats fed SO and SL. There was no difference in plasma lipid profiles between rats fed SO and SL. Arterial blood pressures (BP) in conscious HFHC-fed rats were similar to those in controls whereas heart rates (HR) in all HFHC-fed groups were similar to one another but were higher than that in controls. These findings demonstrate that (1) the dietary effects of SL on plasma lipid profiles and resting BP and HR are similar to those of SO, (2) PE had positive effects on plasma lipid profiles, and (3) 9-week intake of SL and PE did not have pronounced effects on resting BP but induced tachycardia in SHR.
Asunto(s)
Sistema Cardiovascular/efectos de los fármacos , Grasas de la Dieta/efectos adversos , Grasas de la Dieta/sangre , Hipertensión/dietoterapia , Fitosteroles/efectos adversos , Fitosteroles/sangre , Animales , Presión Sanguínea/efectos de los fármacos , Peso Corporal/efectos de los fármacos , Sistema Cardiovascular/fisiopatología , Dieta , Grasas de la Dieta/administración & dosificación , Modelos Animales de Enfermedad , Frecuencia Cardíaca/efectos de los fármacos , Hipertensión/sangre , Masculino , Tamaño de los Órganos/efectos de los fármacos , Fitosteroles/administración & dosificación , Ratas , Ratas Endogámicas SHR , Aceite de Sésamo/administración & dosificación , Aceite de Sésamo/efectos adversos , Aceite de Sésamo/sangre , Taquicardia/inducido químicamenteRESUMEN
Topical Chinese medicines are used for skin disorders as traditional medicine in Japan. We describe a case of allergic contact dermatitis from a topical Chinese medicine, shi-un-ko.
Asunto(s)
Dermatitis Alérgica por Contacto/etiología , Medicina Tradicional China/efectos adversos , Aceite de Sésamo/efectos adversos , Administración Tópica , Dermatitis Alérgica por Contacto/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Pruebas del Parche , Psoriasis/tratamiento farmacológico , Piel/patologíaAsunto(s)
Hipersensibilidad a los Alimentos/diagnóstico , Hipersensibilidad a los Alimentos/inmunología , Inmunoglobulina E/sangre , Pruebas Inmunológicas/métodos , Aceite de Sésamo/administración & dosificación , Aceite de Sésamo/efectos adversos , Sesamum/efectos adversos , Sesamum/inmunología , Adulto , Anafilaxia/etiología , Anafilaxia/inmunología , Especificidad de Anticuerpos , Humanos , Masculino , Aceite de Sésamo/inmunología , Pruebas CutáneasRESUMEN
A 33-year-old woman presented to the emergency department (ED) with tachypnea, tachycardia, and hypoxia, complaining of dyspnea and paroxysms of dry cough for 2 days. The patient had undergone an unsuccessful in vitro fertilization procedure 1 month earlier and had had another embryo implantation 6 days earlier. She had been receiving intramuscular injections of estradiol and progesterone in sesame oil to support implantation. A chest radiograph demonstrated extensive bilateral pulmonary consolidation; a leukocytosis count of 19.7 x 10(9) with 20% eosinophils was noted on a CBC count. A MEDLINE search yielded a case report in infertility literature describing an eosinophilic pneumonitis with similar clinical features after injections of progesterone in sesame oil. Treatment with intravenous corticosteroids was initiated in the ED, resulting in symptom and chest radiograph result improvement within 2 days and sparing the patient further imaging and antibiotic therapy.
Asunto(s)
Eosinofilia/etiología , Fertilización In Vitro/efectos adversos , Hipersensibilidad/etiología , Neumonía/etiología , Aceite de Sésamo/efectos adversos , Corticoesteroides/uso terapéutico , Adulto , Eosinofilia/sangre , Eosinofilia/tratamiento farmacológico , Femenino , Humanos , Hipersensibilidad/diagnóstico , Inyecciones Intramusculares , Pulmón/diagnóstico por imagen , Neumonía/diagnóstico por imagen , Neumonía/tratamiento farmacológico , Progesterona/administración & dosificación , Radiografía , Aceite de Sésamo/administración & dosificación , Resultado del TratamientoRESUMEN
Aflatoxin B1 (AFB1) is considered as the most potent liver carcinogen for humans. A method for determination in sesame seeds was developed. AFB1 was extracted by methanol-water, cleaned by immunoaffinity columns and determined by high-performance liquid chromatography with fluorescence detection. The recovery factor and the limit of detection (LOD) of AFB1 in sesame seeds were 111.5% and 0.02 ng g(-1), respectively. Thirty samples of sesame products were examined for the presence of AFB1. After analysis, 77.6% of samples were found to be contaminated. Eight samples exceeded the European Union (EU) limit (2 µg AFB1 kg(-1)). In 15 samples, AFB1 was below the EU limit. Seven samples remained below the LOD. The most contaminated (14.49 ng AFB1 g(-1)) sample was unpeeled packaged sesame seeds. In all samples, aflatoxigenic Aspergilli fungi as well as the risk for AFB1 presence in sesame seed was investigated.
Asunto(s)
Aflatoxina B1/análisis , Carcinógenos Ambientales/análisis , Contaminación de Alimentos , Manipulación de Alimentos , Semillas/química , Aceite de Sésamo/química , Sesamum/química , Aflatoxina B1/toxicidad , Métodos Analíticos de la Preparación de la Muestra , Aspergillus/crecimiento & desarrollo , Aspergillus/aislamiento & purificación , Carcinógenos Ambientales/toxicidad , Cromatografía de Afinidad , Cromatografía Líquida de Alta Presión , Unión Europea , Contaminación de Alimentos/prevención & control , Inspección de Alimentos/métodos , Grecia , Humanos , Internacionalidad , Límite de Detección , Nivel sin Efectos Adversos Observados , Reproducibilidad de los Resultados , Medición de Riesgo , Semillas/efectos adversos , Semillas/microbiología , Aceite de Sésamo/efectos adversos , Aceite de Sésamo/normas , Sesamum/efectos adversos , Sesamum/microbiología , Espectrometría de FluorescenciaRESUMEN
OBJECTIVE: To report the occurrence and management of pulmonary compromise, marked leukocytosis, and eosinophilia in a patient receiving P-in-oil after IVF and embryo transfer. DESIGN: Case report.A tertiary referral reproductive medicine unit. PATIENT(S): A 29-year-old patient receiving P-in-oil supplementation after IVF embryo transfer. INTERVENTION(S): Extensive diagnostic testing and surveillance for hypersensitivity to P in sesame oil; development of an alternative oil-based P-in-oil suspension. MAIN OUTCOME MEASURE(S): Tolerance of alternative P vehicle; clinical pregnancy. RESULT(S): The patient tolerated an alternative P oil vehicle and successfully achieved a clinical pregnancy after frozen embryo transfer. CONCLUSION(S): Although rare, hypersensitivity reactions may occur in patients receiving P-in-oil supplementation after IVF embryo transfer. Testing for tolerance and subsequent use of alternative P vehicles may be an effective strategy in managing patients with sensitivity to P-in-oil.
Asunto(s)
Hipersensibilidad a las Drogas/etiología , Transferencia de Embrión , Fertilización In Vitro , Vehículos Farmacéuticos/efectos adversos , Progesterona/administración & dosificación , Aceite de Sésamo/efectos adversos , Adulto , Hipersensibilidad a las Drogas/complicaciones , Eosinofilia/etiología , Femenino , Humanos , Leucocitosis/etiología , Enfermedades Pulmonares/diagnóstico por imagen , Enfermedades Pulmonares/etiología , Embarazo , Radiografía TorácicaRESUMEN
Cases of allergy to the oils of groundnut, sunflower, soya and sesame have been described in the literature. In parallel, other authors have affirmed that these oils are not allergenic. The objective of this article is to make the point on this question, to cite the procedures to which the seeds are submitted to extract the oil, to remember that the oils are not composed only of triglycerides and to describe the results of our work. Allergy of oils is a subject that is constantly submitted to controversy and the bibliography does not cease to give contradictory examples. This may be explained by the variations in extraction procedures used by the manufactures, as well as by the conditions of extraction of the proteins in the laboratory.
Asunto(s)
Grasas Insaturadas en la Dieta/efectos adversos , Hipersensibilidad a los Alimentos/etiología , Aceites de Plantas/efectos adversos , Alérgenos/efectos adversos , Alérgenos/aislamiento & purificación , Fraccionamiento Químico/métodos , Grasas Insaturadas en la Dieta/aislamiento & purificación , Proteínas en la Dieta/efectos adversos , Proteínas en la Dieta/aislamiento & purificación , Humanos , Aceite de Cacahuete , Extractos Vegetales/química , Aceites de Plantas/aislamiento & purificación , Proteínas de Plantas/efectos adversos , Proteínas de Plantas/aislamiento & purificación , Plantas Comestibles/química , Desnaturalización Proteica , Semillas/química , Aceite de Sésamo/efectos adversos , Aceite de Sésamo/aislamiento & purificación , Solubilidad , Solventes , Aceite de Soja/efectos adversos , Aceite de Soja/aislamiento & purificación , Aceite de GirasolRESUMEN
BACKGROUND & AIMS: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. METHODS: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil(TM)] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. RESULTS: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) and 43% reduction of HbA(1c) (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P < 0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. CONCLUSIONS: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia.
Asunto(s)
Diabetes Mellitus Tipo 2/dietoterapia , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Interacciones Alimento-Droga , Gliburida/uso terapéutico , Hipoglucemiantes/uso terapéutico , Aceite de Sésamo/uso terapéutico , Antioxidantes/análisis , Terapia Combinada , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/enzimología , Dislipidemias/prevención & control , Femenino , Gliburida/efectos adversos , Hemoglobina Glucada/análisis , Humanos , Hiperglucemia/prevención & control , Hipoglucemiantes/efectos adversos , Masculino , Persona de Mediana Edad , Oxidorreductasas/sangre , Aceite de Sésamo/efectos adversos , Índice de Severidad de la EnfermedadRESUMEN
This study examined the dietary effects of sesame oil (SO)-based structured lipids (SL) and phytosteryl esters (PE) on cardiovascular function in conscious spontaneously hypertensive rats (SHR) fed high-fat (HF) diets (20% w/w fat). The dietary groups were as follows: normal diet (4.5% w/w fat), SO, SO fortified with PE (SOP), SL, and SL fortified with PE (SLP). Mean arterial blood pressures were similar in all groups, whereas resting heart rates (HR) were higher in all HF-fed groups. The pressor responses to the alpha1-adrenoceptor agonist, phenylephrine (5 microg/kg), were similar in all groups. However, the pressor responses to phenylephrine (10 microg/kg) were diminished in SO- or SL-fed SHR, whereas they were not diminished in SOP- or SLP-fed SHR. The depressor responses elicited by the nitric oxide (NO) donor, sodium nitroprusside (5 and 10 microg/kg), were not diminished in HF-fed rats. Baroreflex-mediated changes in HR were variously decreased in the HF-fed groups, and this decrease tended to be greater in SOP and SLP than in SO and SL groups. The depressor and tachycardic responses elicited by the beta-adrenoceptor agonist, isoproterenol, were equivalent in all groups. The depressor responses elicited by the endothelium-dependent agonist, acetylcholine (0.1 microg/kg), and the hypertension elicited by the NO synthesis inhibitor, NG-nitro-L-arginine methylester (25 micromol/kg), were similar in all groups. These findings demonstrate that (1) HF diets increase resting HR and impair baroreflex function in SHR, whereas they do not obviously affect endothelium-dependent vasodilation, and (2) fortification with PE may be deleterious to cardiovascular function (eg, baroreflex activity) in SHR.
Asunto(s)
Sistema Cardiovascular/efectos de los fármacos , Grasas de la Dieta/efectos adversos , Hipertensión/fisiopatología , Fitosteroles/efectos adversos , Animales , Barorreflejo/efectos de los fármacos , Presión Sanguínea/efectos de los fármacos , Sistema Cardiovascular/fisiopatología , Grasas de la Dieta/farmacología , Endotelio Vascular/efectos de los fármacos , Frecuencia Cardíaca/efectos de los fármacos , Masculino , Fitosteroles/farmacología , Distribución Aleatoria , Ratas , Ratas Endogámicas SHR , Aceite de Sésamo/efectos adversos , Aceite de Sésamo/farmacología , Vasodilatación/efectos de los fármacosRESUMEN
A case of contact sensitivity to the unsaponifiable substances in sesame oil is reported. An ointment composed of 60% sesame oil was used for the treatment of a burn on the forearm. 10 days later, contact dermatitis developed. The allergens were shown to be sasamin and sesamolin, which are unsaponifiable substances in sesame oil.
Asunto(s)
Quemaduras/terapia , Erupciones por Medicamentos/etiología , Aceites de Plantas/efectos adversos , Aceite de Sésamo/efectos adversos , Adulto , Femenino , Humanos , Pruebas del Parche , Aceite de Sésamo/administración & dosificación , Relación Estructura-ActividadRESUMEN
Ten cases of carcinoma of the lung, mostly alveolar cell carcinomata, arising in patients after continuous use of (mostly mineral) oils as nose drops or laxatives, have till now been reported in the literature. We describe another such case, a man who used sesame oil to lubricate his tracheal cannula.