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1.
Nature ; 629(8011): 295-306, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38720037

RESUMEN

Fossil fuels-coal, oil and gas-supply most of the world's energy and also form the basis of many products essential for everyday life. Their use is the largest contributor to the carbon dioxide emissions that drive global climate change, prompting joint efforts to find renewable alternatives that might enable a carbon-neutral society by as early as 2050. There are clear paths for renewable electricity to replace fossil-fuel-based energy, but the transport fuels and chemicals produced in oil refineries will still be needed. We can attempt to close the carbon cycle associated with their use by electrifying refinery processes and by changing the raw materials that go into a refinery from fossils fuels to carbon dioxide for making hydrocarbon fuels and to agricultural and municipal waste for making chemicals and polymers. We argue that, with sufficient long-term commitment and support, the science and technology for such a completely fossil-free refinery, delivering the products required after 2050 (less fuels, more chemicals), could be developed. This future refinery will require substantially larger areas and greater mineral resources than is the case at present and critically depends on the capacity to generate large amounts of renewable energy for hydrogen production and carbon dioxide capture.


Asunto(s)
Dióxido de Carbono , Combustibles Fósiles , Industria del Petróleo y Gas , Energía Renovable , Ciclo del Carbono , Dióxido de Carbono/efectos adversos , Dióxido de Carbono/aislamiento & purificación , Carbón Mineral/efectos adversos , Carbón Mineral/provisión & distribución , Combustibles Fósiles/efectos adversos , Combustibles Fósiles/provisión & distribución , Hidrógeno/química , Gas Natural/efectos adversos , Gas Natural/provisión & distribución , Petróleo/efectos adversos , Petróleo/provisión & distribución , Energía Renovable/estadística & datos numéricos , Industria del Petróleo y Gas/métodos , Industria del Petróleo y Gas/tendencias
2.
Calcif Tissue Int ; 115(2): 117-123, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38902530

RESUMEN

The cause of Paget's disease of bone (PDB) is unknown. It emerged as a distinct entity in Britain in the late nineteenth century when it was prevalent, and florid presentation not uncommon. Epidemiological surveys in the 1970s showed that Britain had a substantially higher prevalence of PDB than any other country. Studies in the late twentieth and early twenty-first centuries have documented an unexplained change in presentation, with a greatly reduced prevalence and less severe disease than formerly. The emergence of PDB in Britain coincided with rapid industrialization which, in turn, was driven by the use of coal for energy. In the home, bituminous coal was customarily burnt on an open hearth for heating. Using data on coal production, population size, and estimates of domestic use, the estimated exposure to domestic coal burning rose threefold in Britain during the nineteenth century and began to fall after 1900. This pattern fits well with the decline in PDB documented from death certification and prevalence surveys. Colonists moving from Britain to North America, Australia and New Zealand established coal mines and also used coal for domestic heating. PDB was found in these settler populations, but was largely absent from people indigenous to these lands. In all parts of the world PDB prevalence has fallen as the burning of coal in open hearths for domestic heating has reduced. The nature of the putative factor in coal that could initiate PDB is unknown, but possible candidates include both organic and inorganic constituents of bituminous coal.


Asunto(s)
Carbón Mineral , Osteítis Deformante , Humanos , Carbón Mineral/efectos adversos , Osteítis Deformante/epidemiología , Reino Unido/epidemiología , Historia del Siglo XIX , Prevalencia , Historia del Siglo XX , Minas de Carbón
3.
J Korean Med Sci ; 39(30): e227, 2024 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-39106890

RESUMEN

BACKGROUND: Cancer is a leading cause of death worldwide, posing a significant threat to human health and life expectancy. Numerous existing studies explored the correlation between coal-fired power plants and cancer development. Currently, Chungcheongnam-do Province hosts 29 coal-fired power plants, constituting half of the total 58 plants across South Korea. METHODS: This study assessed the cancer incidence by proximity to coal-fired power plants in Chungcheongnam-do Province, Korea. In this study, the exposed group comprised individuals residing within a 2-km radius of the coal-fired power plants, whereas the control group comprised individuals who had no prior residency within the 2-km radius of such plants or elsewhere in the province. Standardized incidence ratios were calculated using the cancer incidence cases retrieved from the National Health Insurance System data from 2007 to 2017. RESULTS: The study found that exposed men had a 1.11 (95% confidence interval [CI], 1.09-1.21) times higher risk of developing all cancer types and a 1.15 (95% CI, 1.09-1.22) times higher risk of developing cancers excluding thyroid cancer compared with control men. Exposed women had a 1.05 (95% CI, 1.00-1.14) times higher risk of developing all cancer types and a 1.06 (95% CI, 0.98-1.13) times higher risk of developing cancers excluding thyroid cancer than did control women. The colorectal, liver, prostate, and bladder cancer incidence rates were significantly higher in exposed men than that in all control groups. The incidence of esophageal, stomach, liver, and lung cancers were significantly higher in exposed women compared with all control groups. CONCLUSION: The residents near coal-fired power plants had a higher risk of developing cancer than did those living in other areas. In the future, long-term follow-up investigations in residents living in the vicinity of power plants are warranted.


Asunto(s)
Carbón Mineral , Neoplasias , Centrales Eléctricas , Humanos , República de Corea/epidemiología , Masculino , Femenino , Neoplasias/epidemiología , Incidencia , Carbón Mineral/efectos adversos , Programas Nacionales de Salud , Persona de Mediana Edad , Factores de Riesgo , Adulto , Anciano , Exposición a Riesgos Ambientales/efectos adversos
4.
Appl Radiat Isot ; 205: 111158, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38159450

RESUMEN

The risk of lung cancer or pneumoconiosis mortality, increases with radioactive radon gas exposures. This article report health risk for underground workers exposed to radioactive gas and radon daughters carried by airborne dust at the coal mining in the Central Mountainous Region of Colombia. A set of 33 measurement points located in that mine galleries were selected to monitor radon gas concentration activity, by passive LR-115 detectors, during two months. Resulting values provided radon concentrations, absorbed dose, environmental equivalent dose and the effective dose; miners increased risk of contracting lung cancer is included. It is concluded that the mine ventilation system satisfies the conditions required by the current radiological protection of the miners. Our study point out that Colombia can effectively address the potential risks associated with radon exposure and ensure a safer living environment for its citizens.


Asunto(s)
Neoplasias Pulmonares , Exposición Profesional , Radón , Humanos , Radón/efectos adversos , Radón/análisis , Neoplasias Pulmonares/etiología , Colombia , Hijas del Radón/análisis , Carbón Mineral/efectos adversos , Exposición Profesional/efectos adversos
5.
Artículo en Inglés | MEDLINE | ID: mdl-39147445

RESUMEN

Coal is a mixture of several chemicals, many of which have mutagenic and carcinogenic effects and are a key contributor to the global burden of mortality and disease. Previous studies suggest that coal is related to telomeric shortening in individuals occupationally exposed, however little is known about the effects of mining and burning coal on the telomeres of individuals living nearby. Therefore, the primary objective of this investigation was to assess the impact of proximity to coal power plants and coal mines on the genomic instability of individuals environmentally exposed, while also exploring potential associations with individual characteristics, oxidative stress, inflammatory responses, and the presence of inorganic elements. This study involved 80 men participants from three cities around a thermoelectric power plant and one city unexposed to coal and byproducts. DNA was extracted from peripheral blood samples obtained from each participant, and the telomeres length (TL) was assessed using quantitative real-time polymerase chain reaction (qPCR) methodology. No significant difference was observed between exposed individuals (6227 ± 2884 bp) when compared to the unexposed group (5638 ± 2452 bp). Nevertheless, TL decrease was associated with age and risk for cardiovascular disease; and longer TL was found to be linked with increased concentrations of silicon and phosphorus in blood samples. No correlations were observed between TL with comet assay (visual score), micronucleus test, oxidative stress, and inflammatory results. Additional research is required to ascertain the potential correlation between these changes and the onset of diseases and premature mortality.


Asunto(s)
Carbón Mineral , Daño del ADN , Exposición a Riesgos Ambientales , Estrés Oxidativo , Centrales Eléctricas , Telómero , Humanos , Masculino , Carbón Mineral/efectos adversos , Persona de Mediana Edad , Adulto , Exposición a Riesgos Ambientales/efectos adversos , Telómero/efectos de los fármacos , Telómero/genética , Estrés Oxidativo/efectos de los fármacos , Acortamiento del Telómero/efectos de los fármacos , Ensayo Cometa , Pruebas de Micronúcleos , Minas de Carbón , Exposición Profesional/efectos adversos , Anciano , Homeostasis del Telómero/efectos de los fármacos
6.
J Ayub Med Coll Abbottabad ; 35(3): 482-486, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38404098

RESUMEN

Anthracosis is a type of mild pneumoconiosis secondary to harmless carbon dust deposits. Although anthracosis was previously associated with inhaled coal particles, such as coal workers' pneumoconiosis, this hypothesis was later abandoned; pathology has been associated with inhaled dust particles. Our paper is the first case report of ANCA-associated vasculitis and anthracosis coexistence. In addition, it aims to highlight that histopathologically proven anthracotic granulomatous nodules can show high FDG uptake in PET/CT contrary to expectation. We present a case of a 73-year-old male with p-ANCA-associated vasculitis and anthracotic lung nodules accompanied by radiological and clinical findings. The patient got diagnosis with p-ANCA-associated vasculitis with serological and rheumatological tests. Atypically, the clinical findings of the patient were weak (No dyspnoea, cough or additional pulmonary complaints). Nodules were present on X-ray graphics and nodules' contours were irregular on CT. On PET/CT, SUV values of the nodules were high [12 kBq/mL]. Histopathological specimens showed multiple lung granulomas including anthracosis particles. Until performing the biopsy, we could not exclude the possibility of malignancy. Conclusion: When lung involvement of vasculitis is superimposed by anthracosis, it can create granulomas with high SUV values. The relationship between anthracosis and parenchymal lung diseases is a current topic and many recently published papers are present on this subject. To the best of our knowledge, our paper is the first paper showing the relationship between parenchymal involvement of vasculitis and anthracosis in the literature. Environmental pollution and dust particles are the known reasons for anthracosis particles in the nodules. It is open to future research on whether air pollution triggers new atypical cases or not.


Asunto(s)
Antracosis , Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos , Neumoconiosis , Masculino , Humanos , Anciano , Tomografía Computarizada por Tomografía de Emisión de Positrones , Antracosis/complicaciones , Antracosis/diagnóstico , Antracosis/patología , Polvo , Carbón Mineral/efectos adversos , Granuloma
8.
Rev. salud pública ; 19(3): 362-367, mayo-jun. 2017. tab
Artículo en Español | LILACS | ID: biblio-903116

RESUMEN

RESUMEN Objetivo Evaluar la percepción de calidad de vida en habitantes de zonas mineras de explotación de carbón mineral y zonas agrícolas Materiales y Métodos Estudio de corte trasversal descriptivo en 228 individuos habitantes de municipios de explotación de carbón (n=151) y de municipios con actividades agrícolas (n=78). Quienes respondieron encuesta SF36 y test socio demográfico. Resultados Se encontró que la percepción de la calidad de vida relacionada con la salud es menor en los habitantes del área de explotación del carbón frente a los habitantes de zona agrícola solo con diferencia estadística en la percepción general de la escala y sin diferencia pro cada una de las escalas. Discusión La contaminación generada en zonas de explotación minera de carbón repercute en la salud de las personas y su percepción de calidad de vida, la evidencia es débil al no demostrar diferencias estadísticamente significativas por área en cada subescala y solo se demostró en percepción general.(AU)


ABSTRACT Objective To evaluate the perception of quality of life in inhabitants of mineral mining areas of mineral coal and agricultural areas. Materials and Methods Descriptive cross-sectional study of 229 individuals living in coal mining municipalities (n=151) and municipalities with agricultural activities (n=78). Those who answered SF36 survey and socio-demographic test. Results It was found that the perception of the health-related quality of life is lower in the inhabitants of the area of coal exploitation compared to the inhabitants of agricultural zone only with statistical difference in the general perception of the scale and with no difference pro each one of the scales. Discussion Pollution generated in coal mining areas has an impact on the health of people and their perception of quality of life. The evidence is weak in showing no statistically significant differences by area in each subscale and was only demonstrated in general perception.(AU)


Asunto(s)
Humanos , Calidad de Vida , Salud Ambiental , Carbón Mineral/efectos adversos , Minería , Epidemiología Descriptiva , Estudios Transversales , Colombia
9.
Med. clín (Ed. impr.) ; 153(3): 100-105, ago. 2019. mapas, graf, tab
Artículo en Español | IBECS (España) | ID: ibc-183431

RESUMEN

Introducción y objetivos: Actualmente en España, la quema del carbón sigue siendo una de las fuentes principales de electricidad. Su combustión genera la emisión de múltiples sustancias nocivas, entre ellas, las partículas PM2,5 que se han relacionado con incrementos en morbimortalidad cardiovascular. Los objetivos del estudio son: 1) determinar la distribución geográfica nacional de dichas partículas y su posible asociación con la proximidad a las centrales térmicas de carbón y 2) estimar el impacto sobre la salud cardiovascular derivado de las emisiones de partículas PM2,5 de las centrales térmicas de carbón en España durante el año 2014. Métodos: Para realizar el estudio de dispersión de los contaminantes atmosféricos procedentes de las centrales térmicas se empleó el modelo matemático CALPUFF. Los datos demográficos y epidemiológicos se obtuvieron del Instituto Nacional de Estadística. Se emplearon metodologías validadas en el ámbito internacional para valorar la asociación contaminante-respuesta. Resultados: El número total de defunciones atribuibles al carbón fue de 709 casos, de los cuales 586 (82,6%) se relacionaron con las partículas PM2,5. La mayor parte de ellas fueron debidas a infartos, ictus fatales y a insuficiencia cardiaca, que constituyeron un total de 170 de las muertes por PM2,5 (29%). Las tasas de incidencia más elevadas se observaron en Asturias y Castilla y León. Conclusiones: Este estudio describe un aumento de morbimortalidad cardiovascular en España relacionada con las emisiones procedentes de la quema de carbón. Refleja como aquellas comunidades con mayor presencia de centrales térmicas (Asturias y Castilla y León) fueron las más afectadas y extrapola que sus habitantes tienen un mayor riesgo de mortalidad por exposición a partículas PM2,5


Introduction and objectives: One of the main sources of energy in Spain is still coal combustion. It releases multiple pollutants into the atmosphere, such as PM2.5, that has been linked to an increase in cardiovascular morbidity and mortality. The objectives of this paper are: 1) to determine the national distribution of these particles and their proximity to coal plants, 2) to estimate the cardiovascular impact of PM2.5 particles in Spain in 2014. Methods: In order to complete the national pollutant dispersion study, we used the CALPUFF model. The epidemiologic and demographic data were obtained from the National Statistics Institute. The associations «pollutant-effect» were obtained by internationally validated methodologies. Results: The total number of deaths due to coal pollutants were 709, from which 586 (82.6%) were related to PM2.5 particles. Most of them were due to myocardial infarctions, fatal strokes and heart failure, adding up to 170 cases of mortality related to PM2.5 (29%). The greatest densities were found in the regions of Asturias and Castilla y León. Conclusions: This study describes an increase in cardiovascular mortality and morbidity in Spain, due to coal combustion pollutants. It finds a greater impact in the provinces of Asturias and Castilla León, where a higher presence of coal power plants can be found. This reflects that the people that live in those areas have a greater risk of cardiovascular death due to PM2.5 pollutant exposure from coal


Asunto(s)
Humanos , Contaminación del Aire/efectos adversos , Contaminación Ambiental/efectos adversos , 51777 , Carbón Mineral/efectos adversos , Enfermedades Cardiovasculares/complicaciones , Enfermedades Cardiovasculares/mortalidad , Centrales Eléctricas , Indicadores de Morbimortalidad , Exposición a Riesgos Ambientales/efectos adversos
10.
Rev. Col. Bras. Cir ; 39(6): 469-475, nov.-dez. 2012. ilus, tab
Artículo en Portugués | LILACS | ID: lil-662774

RESUMEN

OBJETIVO: Analisar a eficácia da suspensão de carvão inerte na marcação de lesões impalpáveis mamárias e as alterações morfológicas associadas ao seu uso, além de determinar se há ou não prejuízo na interpretação destas lesões pelo patologista. MÉTODOS: Foram atendidos 135 casos de lesões impalpáveis mamárias, previamente marcadas com suspensão de carvão. As lâminas coradas pelo método de HE contendo pigmentos de carvão foram analisadas ao microscópio óptico, onde se realizou avaliação quantitativa e qualitativa da resposta inflamatória e determinação da presença ou não de prejuízo ao diagnóstico anatomopatológico. Os índices avaliados quantitativamente quanto à resposta inflamatória foram as contagens de linfócitos, células gigantes e neutrófilos, todos observados e quantificados em campos de grande aumento. Foi, ainda, avaliada a quantidade e distribuição de carvão presente nas lesões. RESULTADOS: Na avaliação quantitativa e qualitativa da resposta inflamatória observou-se, independente da quantidade de carvão, granulomas a "corpo estranho" em todas as amostras. Em relação à resposta inflamatória linfocitária 5,19% das amostras não apresentaram infiltração linfocítica, sendo que em 82,22% ela era de discreta intensidade e em 12,59% de moderada intensidade. Quanto à resposta inflamatória aguda, observou-se ausência total de exsudação neutrofílica em 42,96% dos espécimes, exsudação neutrofílica discreta em 42,22%, moderada em 11,11% e acentuada, sob forma de microabscessos, em 3,7% dos casos. Nesta série foram observados cinco nódulos de carvão, posicionados paralesionalmente, e que não geraram interferência na análise morfológica. CONCLUSÃO: Este método é marcador eficaz de lesões impalpáveis, de baixo custo, alta efetividade, sem prejuízo à análise histológica, além de ser de fácil execução; é confortável para a paciente e de grande auxílio ao cirurgião e patologista na localização destas lesões.


OBJECTIVE: To analyze the efficiency of labeling impalpable breast lesions with inert charcoal suspension; to evaluate the morphological alterations associated with its use and to determine whether the use of charcoal labeling hampers the diagnostic interpretation of the pathologist. METHODS: Was evaluated a total of 135 cases of impalpable breast lesions previously labeled with charcoal suspension. Histological H&E stained slides containing charcoal pigments were analyzed using optical microscopy, by which both quantitative and qualitative evaluations with regards to inflammatory response and interference in diagnosis were performed. Lymphocyte, giant cells and neutrophils were evaluated and quantified. Moreover, the distribution of the charcoal suspension present in the lesions was evaluated. RESULTS: As to the quantitative and qualitative evaluation of the inflammatory response caused by the use of charcoal labeling, granulomas were present in all samples regardless of the quantity of injected charcoal. Lymphocytic inflammatory response was absent in only 5.19% of the samples, 82.22% exhibited discrete intensity and 12.59% were moderate. With regards to acute inflammatory response, 42.96% showed total absence of neutrophilic exudate, whereas 42.22% contained discrete and 11.11% moderate neutrophilic exudate, and only 3.7% of cases had intense neutrophilic exudate. CONCLUSION: This study corroborates the utility and easiness of the charcoal method as a mean of efficient labeling of impalpable breast lesions; this technique is easy to use, has a low cost, high efficiency and does not interfere with the histological analysis. Moreover, it is comfortable for the patient and is of great help in finding and localizing the lesions for both the surgeon and pathologist.


Asunto(s)
Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Persona de Mediana Edad , Adulto Joven , Neoplasias de la Mama/patología , Mama/patología , Carbón Mineral , Carbón Mineral/efectos adversos , Estudios de Factibilidad , Inflamación/etiología , Palpación , Patología Clínica/métodos , Suspensiones
11.
Rev. chil. enferm. respir ; 26(2): 72-80, jun. 2010. tab
Artículo en Español | LILACS | ID: lil-577322

RESUMEN

The aim of this study is to report the association between indoor pollution (IP), chronic respiratory symptoms (CRS) and chronic obstructive pulmonary disease (COPD). Data provided from PLATINO study considering a sample of 1.208 subjects 40 and over years old population in Santiago, Chile. Analyses regarding indoor air pollution variables, smoking, environmental tobacco smoke (ETS) and lifetime exposure to occupational dust and CRS and COPD as main outcomes was performed. Crude and adjusted prevalence odds ratios (POR) were calculated using logistic regression, adjusting for potential confounders. Variables explaining higher COPD risk were age > 60 years (POR 3.94, CI95 percent 2.87-5.41, p < 0.01) and males (POR 2.08, CI95 percent 1.53-2.83, p < 0.01). Exposure to coal IP was associated with CRS (POR 1.41, CI95 percent 1.05-1.89; p = 0.024), as well as exposure to firewood IP (POR 1.42, CI95 percent 1.04-1.93; p = 0.029) and ETS (POR 2.15, CI95 percent 1.24-3.73, p = 0.006). Exposure to coal, firewood and ETS are independent risk factors for CRS. Association between exposure to IP and COPD was not observed.


El objetivo de la comunicación fue evaluar la asociación entre contaminación intradomiciliaria (CID) y la presencia de síntomas respiratorios crónicos (SRC) y Enfermedad Pulmonar Obstructiva Crónica (EPOC). Se analizó información del estudio de prevalencia Platino en base a una muestra de población general de 1.208 sujetos de 40 y más años de Santiago, Chile. Se analizó la CID derivada del uso de combustibles sólidos, exposición a humo ambiental (EHAT) y el reporte de exposición previa a polvo de origen ocupacional calculando Odds Ratio de Prevalencia (ORP) crudos y ajustados por potenciales variables confundentes. Las variables que determinan mayor riesgo de EPOC fueron edad mayor 60 años (ORP 3,9; IC95 por ciento 2,9-5,4; p < 0,01) y sexo masculino (OR 2,08; IC95 por ciento 1,5-2,8; p < 0,01). La CID derivada de carbón se asoció con síntomas respiratorios crónicos (ORP 1,4; IC95 por ciento 1,05-1,89; p = 0,024), al igual que el antecedente de exposición a humo de leña (ORP 1,4, IC95 por ciento 1,04-1,9; p = 0,029) y EHAT (ORP 2,1, IC95 por ciento 1,2-3,7; p = 0,006). La exposición a carbón, leña y EHAT constituyen factores de riesgo independientes para presentar SRC. No se encontró asociación entre CID y EPOC.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Contaminación del Aire Interior/efectos adversos , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Enfermedad Pulmonar Obstructiva Crónica/etiología , Exposición por Inhalación/efectos adversos , Factores de Edad , Biomasa , Carbón Mineral/efectos adversos , Chile/epidemiología , Contaminación por Humo de Tabaco/efectos adversos , Contaminantes Ocupacionales del Aire/efectos adversos , Disnea/epidemiología , Disnea/etiología , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Gases/efectos adversos , Modelos Logísticos , Prevalencia , Parafina/efectos adversos , Espirometría , Tos/epidemiología , Tos/etiología , Área Urbana
12.
Rev. bras. med. esporte ; 12(2): 81-84, mar.-abr. 2006. graf
Artículo en Portugués | LILACS | ID: lil-450174

RESUMEN

Estudos têm apontado o exercício físico regular de baixa a moderada intensidade como um importante agente no combate ao estresse oxidativo. O objetivo deste estudo foi investigar o efeito do exercício físico regular na resposta oxidativa pulmonar após a inalação de pó de carvão mineral. Vinte e quatro ratos Wistar machos (200-250g) foram divididos aleatoriamente em dois grupos com respectivos controles (treinado, n = 6 e não-treinado, n = 6). Os animais receberam, por instilação traqueal, pó de carvão mineral (3mg/0,5ml salina, três dias/semana, durante três semanas) ou 0,5ml de solução salina 0,9 por cento. Quarenta e oito horas após a última instilação, o grupo treinado foi submetido a um programa de exercício progressivo em esteira durante 12 semanas (até 17m.min-1, 50min.dia-1, 10 por cento de inclinação). Quarenta e oito horas após a última sessão de treinamento, todos os animais foram mortos por decapitação e os pulmões e sóleo foram cirurgicamente removidos para posterior análise bioquímica. A atividade da citrato-sintase foi determinada no músculo sóleo e os danos em lipídios e proteínas foram avaliados nos pulmões pela concentração de TBARS e pela determinação de grupos carbonil, respectivamente. Os resultados mostram que a prática regular de exercício físico reduz significativamente os níveis presentes de TBARS em ratos treinados e diminui os níveis de oxidação em proteínas em ambos os grupos quando comparados com os respectivos controles. Os resultados nos levam a sugerir que o exercício físico regular em esteira é um agente capaz de amenizar os danos oxidativos pulmonares induzidos pela inalação de partículas de carvão mineral.


Several studies have pointed the regular low to moderate intensity physical exercise an important agent to combat the oxidant stress. The purpose of this study was to investigate the effect of the physical exercise in the pulmonary oxidant response after inhaling mineral coal dust. Twenty-four male Wistar rats (200-250 g) were randomly divided in two groups with their respective controls (trained, n = 6; non-trained, n = 6). All animals received mineral coal dust via tracheal instillation (saline 3 mg/0.5 ml, 3 days/week for 3 weeks), or 0.5 ml of 0.9 percent saline solution. Forty-eight hours after the last instillation, the trained group was submitted to a progressive exercise program on treadmill for twelve weeks (up to 17 m.min-1, 50 min/day-1, 10 percent inclination). Forty-eight hours after the last training session, every animal was killed by decapitation, and their lungs and soleus were surgically removed for later biochemical analysis. The citrate synthase activity was determined in the soleus muscle, and the damages on the lipids and proteins were assessed into the lungs by means of the TBARS concentration and by determining the carbonyl groups, respectively. The results show that the regular practice of physical exercises reduces significantly the present TBARS levels in trained rats, decreasing the oxidation levels in proteins of both groups compared to their respective controls. The results lead us to suggest that the regular physical exercise on treadmill is an agent capable to soften the pulmonary oxidant damages caused by inhaling mineral coal particles.


Los estudios han estado apuntando el ejercicio físico regular de intensidad baja a moderada como un agente importante en el combate a la tensión oxidativa. El objetivo de ese estudio era investigar el efecto del ejercicio físico para regular la respuesta oxidativa pulmonar después de la inhalación de polvo de carbón mineral. Veinticuatro ratones varones Wistar (200-250g) fueron aleatoriamente divididos en 2 grupos con los mandos respectivos (, n = 6 y Ningún -, n = 6). Los animales recibieron, por instilación traqueal polvo de carbón mineral (3mg/0,5ml salina, 3 dias/semana, durante 3 semanas) o 0,5ml de solución salina 0,9 por ciento. Cuarenta ocho horas después de la última instilación, el grupo especializado fue sometido a un programa de ejercicio progresivo en la cinta durante 12 semanas (a 17m.min-1, 50min.dia-1, 10 por ciento de inclinación). Cuarenta ocho horas después de la última sesión de entrenamiento, todos los animales fueron sacrificados por decapitación y los pulmones y el músculo sóleo fueron extirpados por cirugía para el análisis bioquímico subsecuente. La actividad de la citrato-sintetasa fue determinada en los músculos así como los daños y perjuicios en los lipidos y las proteínas se estimaron en los pulmones para la concentración de TBARS y para la determinación de carbonilo de estos grupos, respectivamente. Los resultados mostraron que el ejercicio físico regular reduce los niveles presentes de TBARS significativamente en los ratones especializados y reduce los niveles de la oxidación en las proteínas en ambos grupos cuando se compararon los grupos respectivos. Los resultados permitieron sugerir que el ejercicio físico regular en la cinta es un agente capaz minimizarlos daños y perjuicios oxidativos pulmonares inducidos por la inhalación de partículas de carbón mineral.


Asunto(s)
Animales , Ratas , Carbón Mineral/efectos adversos , Ejercicio Físico/fisiología , Exposición por Inhalación , Pulmón , Estrés Oxidativo , Radicales Libres/metabolismo , Prueba de Esfuerzo/métodos , Ratas Wistar
13.
Rev. chil. salud pública ; 3(2/3): 92-8, 1999. ilus, tab, graf
Artículo en Español | LILACS | ID: lil-277977

RESUMEN

Actualmente se sabe que la calidad del aire intradomiciliario puede ser un factor tanto o más importante que la contaminación exterior en términos de salud de la población, lo que se debe principalmente al uso de fuentes de energía altamente contaminantes. Problema que adquiere gran importancia en aquellas ciudades con clima frío y lluvioso en donde las personas permanecen preferentemente en lugares cerrados. Por lo tanto, la elección de una determinada alternativa energética para calefacción debe considerar variables cualitativas y cuantitativas tales como: el beneficio entregado, el costo y los potenciales riesgos en salud y medioambiente. Con el objetivo de integrar la mayoría de los criterios de decisión, definidos sobre la base de su importancia relativa, se aplicó a 10 usuarios (incluidos los autores) una moderna y flexible herramienta de análisis multicriterio usada en la toma de decisiones denominada Analytic Hierarchy Process (AHP). Las alternativas energéticas analizadas fueron: gas, parafina, leña CL (combustión lenta), Leña N (combustión normal), electricidad (sistema oleolítico) y carbón. El análisi del conjunto de los criterios muestra que la electricidad es la mejor alternativa (49 por ciento) seguida del gas (30 por ciento), ambos sistemas fueron significativamente mejores que los otros. este estudio sugiere que el uso de herramientas modernas aplicadas como apoyo en la toma de decisiones en gestión ambiental, permiten evaluar objetivamente un importante problema de salud pública


Asunto(s)
Humanos , Contaminación del Aire Interior/prevención & control , Calefacción/métodos , Contaminantes Atmosféricos/efectos adversos , Contaminantes Atmosféricos/análisis , Calefacción/efectos adversos , Carbón Mineral/efectos adversos , Carbón Mineral , Combustibles Fósiles/efectos adversos , Combustibles Fósiles , Incendios , Toma de Decisiones , Electricidad/efectos adversos , Suministros de Energía Eléctrica/efectos adversos , Suministros de Energía Eléctrica , Medición de Riesgo/métodos , Parafina/efectos adversos , Factores de Riesgo
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