1.
J Org Chem
; 83(18): 11318-11322, 2018 09 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30015484
RESUMEN
A short formal synthesis of ent-Cephalotaxine is achieved. The approach features a new Lewis acid-mediated [2,3]-Stevens rearrangement of N-allylated prolineamide to generate a key quaternary stereogenic center. Additionally, a one-pot Parham-aldol sequence was developed to rapidly assemble two of the four rings in the cephalotaxine core.