Asunto(s)
Neuritis del Plexo Braquial/inducido químicamente , Neuritis del Plexo Braquial/diagnóstico , Vacunas contra la COVID-19/efectos adversos , Vacunación/efectos adversos , Neuritis del Plexo Braquial/sangre , COVID-19/prevención & control , Vacunas contra la COVID-19/administración & dosificación , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Neuralgic amyotrophy (NA), also known as acute brachial plexitis, is postulated as an autoimmune pathogenesis. In a well-defined cohort of patients with NA, we analyzed the cerebrospinal fluid (CSF) profile and the prevalence of antiganglioside antibodies. Patients with Varicella zoster-associated radiculitis and healthy blood donors served as controls. An abnormal routine laboratory CSF profile was found in 29% of those with NA, mostly showing a disruption of the blood-brain barrier. Antibodies predominantly from the immunoglobulin M (IgM) isotype against at least one human ganglioside were detected in 36% of sera from patients with NA but in only 2% of controls. An NA-specific reactivity pattern was not detected, and there was no significant association with clinical or CSF parameters. This suggests that the seroprevalence of antiganglioside autoantibodies in patients with NA is nonspecific.
Asunto(s)
Neuritis del Plexo Braquial/líquido cefalorraquídeo , Neuritis del Plexo Braquial/inmunología , Gangliósidos/inmunología , Adulto , Anciano , Anciano de 80 o más Años , Autoanticuerpos/sangre , Autoanticuerpos/líquido cefalorraquídeo , Autoanticuerpos/inmunología , Autoantígenos/inmunología , Neuritis del Plexo Braquial/sangre , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Estudios Seroepidemiológicos , Adulto JovenRESUMEN
We report an unusual case of Parsonage-Turner syndrome with relapses and simultaneous bilateral anterior interosseous neuropathy (AIN). A 66-year-old man, after a typical right brachial amyotrophic neuralgia few months previously, underwent surgery for left carpal tunnel syndrome. The day following surgery, wrist aching and bilateral weakness, even if prevalent on the right side, on thumb and index finger flexion appeared. Neurophysiology was consistent with bilateral AIN neuropathy and serology revealed anti-nucleus antibody positivity. Association of relapses with bilateral acute AIN involvement in the subject with autoantibody detection can suggest an immunological pathogenesis.
Asunto(s)
Neuritis del Plexo Braquial/sangre , Neuritis del Plexo Braquial/fisiopatología , Enfermedades del Sistema Nervioso Periférico/sangre , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Anciano , Brazo/fisiopatología , Autoanticuerpos/sangre , Neuritis del Plexo Braquial/patología , Síndrome del Túnel Carpiano/cirugía , Electromiografía , Humanos , Masculino , Músculo Esquelético/fisiopatología , Conducción Nerviosa , Enfermedades del Sistema Nervioso Periférico/patología , Factores de TiempoAsunto(s)
Autoanticuerpos/inmunología , Neuritis del Plexo Braquial/inmunología , Neuritis del Plexo Braquial/microbiología , Infecciones por Campylobacter/inmunología , Adulto , Anciano , Autoanticuerpos/sangre , Autoantígenos/inmunología , Neuritis del Plexo Braquial/sangre , Infecciones por Campylobacter/complicaciones , Campylobacter jejuni/inmunología , Ensayo de Inmunoadsorción Enzimática , Femenino , Gangliósidos/inmunología , Humanos , Masculino , Imitación Molecular/inmunologíaAsunto(s)
Dolor de Espalda/sangre , Dolor/sangre , Triptófano/sangre , Adulto , Anciano , Dolor de Espalda/fisiopatología , Neuritis del Plexo Braquial/sangre , Neuritis del Plexo Braquial/fisiopatología , Femenino , Humanos , Dolor de la Región Lumbar/sangre , Dolor de la Región Lumbar/fisiopatología , Masculino , Persona de Mediana Edad , Neuralgia/sangre , Neuralgia/fisiopatología , Dolor/fisiopatología , Recurrencia , Valores de ReferenciaRESUMEN
A hypothesis that selenium deficiency predisposes the development of occupational cervicobrachial complaints was tested in 134 females working in an assembly factory, with constrained work postures and repetitive work tasks. Seventeen subjects, who reported intake of selenium tablets, had higher plasma selenium levels than the others (104 vs 89 micrograms/l, P = 0.01). Among those who did not take selenium tablets, 21% reported symptoms from the upper back during the last 7d, 21% from the neck, 38% from the shoulders, 15% from the elbows, and 27% from the hands. Subjects with pain in their elbows had slightly, but significantly, lower plasma selenium levels than asymptomatics (84 vs 90 micrograms/l, P = 0.048). For the other anatomical regions, there were no statistically significant differences. Thus, there was no major association between selenium status and pain; conclusions regarding any minor association must await further studies.
Asunto(s)
Neuritis del Plexo Braquial/sangre , Enfermedades Profesionales/sangre , Selenio/sangre , Adulto , Dolor de Espalda/etiología , Neuritis del Plexo Braquial/etiología , Femenino , Humanos , Persona de Mediana Edad , Enfermedades Profesionales/etiología , Selenio/deficienciaRESUMEN
We report 16 adult men (age, 41 to 75 yr) with neuralgic amyotrophy (NA) who presented with dyspnea due to involvement of the diaphragm. All patients developed breathlessness after a prodrome of acute severe neck and shoulder pain. Bilateral diaphragm paralysis (BDP) was confirmed in 12 patients and unilateral diaphragm paralysis (UDP) in four by the absence of electrical and mechanical responses to percutaneous phrenic nerve stimulation. Global expiratory muscle strength was well preserved in all patients, but inspiratory muscle strength was reduced in proportion to the extent of diaphragmatic involvement. Lung function showed low lung volumes with preservation of carbon monoxide transfer coefficient in all patients. Two BDP patients were hypoxic (PaO2 = 67 and 54 mm Hg, respectively) on daytime arterial blood gas analysis; the latter patient with pre-existing chronic obstructive pulmonary disease and marked obesity also had borderline hypercapnia (PaO2 = 49 mm Hg). Overnight sleep studies in three BDP and two UDP patients showed frequent intermittent arterial oxygen desaturations apparently caused by obstructive sleep apneas, but there was no evidence of alveolar hypoventilation. Follow-up muscle studies in five BDP and four UDP patients between 2 and 4 yr after initial referral showed complete recovery of diaphragmatic function in only two UDP patients, one of whom relapsed a year later. We postulate that NA may be an important but underrecognized cause of diaphragmatic paralysis in otherwise normal patients. Diaphragmatic strength returns very slowly, if at all.