Detalhe da pesquisa
1.
Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.
Bioorg Med Chem Lett
; 24(21): 4958-62, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288187
2.
Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg Med Chem Lett
; 24(17): 4110-3, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113934
3.
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 22(7): 2585-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22377514
4.
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg Med Chem Lett
; 22(2): 1019-22, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22222034
5.
Identification of two novel metabolites of SCH 486757, a nociceptin/orphanin FQ peptide receptor agonist, in humans.
Drug Metab Dispos
; 38(11): 2067-74, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20671096
6.
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2519-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339177
7.
The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.
Eur J Pharmacol
; 661(1-3): 63-71, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21545797
8.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Bioorg Med Chem Lett
; 17(11): 3023-7, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428659
9.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Bioorg Med Chem Lett
; 17(11): 3028-33, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17420123