Detalhe da pesquisa
1.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
2.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
3.
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Bioorg Med Chem Lett
; 19(4): 1105-9, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168351
4.
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2519-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339177
5.
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Bioorg Med Chem
; 17(13): 4486-95, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481946
6.
Discovery of novel orally active ureido NPY Y5 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 1146-50, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160282
7.
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
Bioorg Med Chem
; 16(4): 1874-83, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032054
8.
Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 852(1-2): 92-100, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17240204
9.
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
J Med Chem
; 49(3): 995-1005, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451065
10.
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
J Med Chem
; 49(9): 2750-7, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640336
11.
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
J Med Chem
; 49(20): 6074-86, 2006 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17004721
12.
Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.
ACS Med Chem Lett
; 5(3): 244-8, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900812
13.
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
J Med Chem
; 55(2): 754-65, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148957
14.
A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.
J Med Chem
; 55(5): 2089-101, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22247956
15.
The impact of protein on Caco-2 permeability of low mass balance compounds for absorption projection and efflux substrate identification.
J Pharm Biomed Anal
; 51(5): 1069-77, 2010 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20036089
16.
Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
J Med Chem
; 53(8): 3075-85, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20302300
17.
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
ACS Med Chem Lett
; 1(2): 64-9, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900178
18.
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
J Med Chem
; 52(12): 3679-88, 2009 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456105
19.
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J Med Chem
; 52(2): 336-46, 2009 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19102654
20.
Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.
J Med Chem
; 52(5): 1370-9, 2009 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196021