Detalhe da pesquisa
1.
Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.
Bioorg Med Chem Lett
; 24(21): 4958-62, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288187
2.
Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg Med Chem Lett
; 24(17): 4110-3, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113934
3.
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 22(7): 2585-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22377514
4.
Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.
Bioorg Med Chem Lett
; 22(3): 1335-9, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22227212
5.
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg Med Chem Lett
; 22(2): 1019-22, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22222034
6.
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2519-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339177
7.
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Pharmacology
; 84(3): 153-61, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19696521
8.
The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).
J Pharmacol Exp Ther
; 326(2): 672-82, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18492950
9.
The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.
Eur J Pharmacol
; 661(1-3): 63-71, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21545797
10.
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
Eur J Pharmacol
; 630(1-3): 112-20, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20006596
11.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Bioorg Med Chem Lett
; 17(11): 3023-7, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17428659
12.
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Bioorg Med Chem Lett
; 17(11): 3028-33, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17420123