Detalhe da pesquisa
1.
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Bioorg Med Chem Lett
; 56: 128463, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838652
2.
Design and synthesis of water soluble ß-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 26(23): 5836-5841, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27836402
3.
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
J Pharmacol Exp Ther
; 355(3): 397-409, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407721
4.
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Bioorg Med Chem Lett
; 25(15): 2958-62, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048804
5.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 844-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265892
6.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
7.
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Biochemistry
; 50(22): 4973-80, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21528914
8.
Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.
J Pharmacol Exp Ther
; 330(1): 294-303, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19332567
9.
Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.
Bioorg Med Chem Lett
; 19(21): 6032-7, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800786
10.
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Bioorg Med Chem Lett
; 19(21): 6018-22, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800231
11.
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Psychopharmacology (Berl)
; 200(3): 393-401, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18594798
12.
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 215-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988864
13.
Discovery of novel orally active ureido NPY Y5 receptor antagonists.
Bioorg Med Chem Lett
; 18(3): 1146-50, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160282
14.
Accuracy of data buoys for measurement of cyanobacteria, chlorophyll, and turbidity in a large lake (Lake Erie, North America): implications for estimation of cyanobacterial bloom parameters from water quality sonde measurements.
Environ Sci Pollut Res Int
; 25(25): 25175-25189, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29943249
15.
Bioprinted 3D Primary Human Intestinal Tissues Model Aspects of Native Physiology and ADME/Tox Functions.
iScience
; 2: 156-167, 2018 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30428372
16.
Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators.
ACS Med Chem Lett
; 8(10): 1002-1006, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057041
17.
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AßPPswe Mice Without Inducing Microhemorrhage.
J Alzheimers Dis
; 59(4): 1393-1413, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800329
18.
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.
Mol Neurodegener
; 12(1): 39, 2017 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28521765
19.
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J Med Chem
; 60(7): 2983-2992, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28245354
20.
Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
J Med Chem
; 49(8): 2661-5, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610810