Detalhe da pesquisa
1.
Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.
Brain Behav Immun
; 56: 271-80, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044335
2.
Lysophosphatidic acid receptor 1 antagonist (EPGN2154) causes regression of NASH in preclinical NASH models.
Hepatol Commun
; 7(12)2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37994050
3.
Role of endogenous adenine in kidney failure and mortality with diabetes.
medRxiv
; 2023 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398187
4.
Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients.
J Clin Invest
; 133(20)2023 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37616058
5.
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia.
Bioorg Med Chem Lett
; 22(1): 421-6, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153347
6.
Influence of pKa on the biotransformation of indene H1-antihistamines by CYP2D6.
Bioorg Med Chem Lett
; 21(3): 947-51, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21232954
7.
Therapeutic efficacy of α7 ligands after acute ischaemic stroke is linked to conductive states of α7 nicotinic ACh receptors.
Br J Pharmacol
; 178(7): 1684-1704, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496352
8.
Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
Bioorg Med Chem Lett
; 20(19): 5874-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20800486
9.
Novel benzothiophene H1-antihistamines for the treatment of insomnia.
Bioorg Med Chem Lett
; 20(7): 2316-20, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20188547
10.
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(17): 4817-22, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18682322
11.
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(3): 1124-30, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18082401
12.
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Bioorg Med Chem Lett
; 18(6): 1931-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18294847
13.
5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.
Bioorg Med Chem Lett
; 18(11): 3344-9, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18442905
14.
Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
Bioorg Med Chem Lett
; 18(11): 3301-5, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18442910
15.
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Bioorg Med Chem Lett
; 18(1): 129-36, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032040
16.
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
Bioorg Med Chem
; 16(10): 5606-18, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18417348
17.
Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists.
Med Chem
; 4(1): 67-74, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18220971
18.
Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.
Oncotarget
; 9(34): 23462-23481, 2018 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29805748
19.
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
J Med Chem
; 50(25): 6356-66, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994683
20.
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor.
Bioorg Med Chem Lett
; 17(24): 6825-31, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964151