Your browser doesn't support javascript.
loading
Diagnostic performance of thyroid ultrasound in Hürthle cell carcinomas
Santana, Nathalie Oliveira; Freitas, Ricardo Miguel Costa; Marcos, Vinicius Neves; Chammas, Maria Cristina; Camargo, Rosalinda Yossie Asato; Schmerling, Cláudia Kliemann; Vanderlei, Felipe Augusto Brasileiro; Hoff, Ana Oliveira; Marui, Suemi; Danilovic, Debora Lucia Seguro.
Afiliación
  • Santana, Nathalie Oliveira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Freitas, Ricardo Miguel Costa; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo. São Paulo. BR
  • Marcos, Vinicius Neves; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo. São Paulo. BR
  • Chammas, Maria Cristina; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Camargo, Rosalinda Yossie Asato; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Schmerling, Cláudia Kliemann; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo. São Paulo. BR
  • Vanderlei, Felipe Augusto Brasileiro; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Hoff, Ana Oliveira; Universidade de São Paulo. Faculdade de Medicina. Instituto do Câncer do Estado de São Paulo. São Paulo. BR
  • Marui, Suemi; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Danilovic, Debora Lucia Seguro; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 63(3): 300-305, May-June 2019. tab, graf
Article en En | LILACS | ID: biblio-1011171
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT Objective Hürthle cell carcinomas (HCCs) of the thyroid have been recently reclassified as a separate entity due to their distinct clinical and molecular profiles. Few studies have assessed the ability of preoperative characteristics in differentiating HCCs from Hürthle cell adenomas (HCAs) due to the low prevalence of both lesions. This study aimed to compare the preoperative features of HCCs and HCAs and evaluate the diagnostic performance of ultrasound in distinguishing between both. Subjetcs and methods Retrospective study including 101 patients (52 HCCs and 49 HCAs) who underwent thyroid surgery from 2000 to 2016. Clinical, ultrasonographic, and histological data were reviewed. Diagnostic performance of suspicious sonographic features was analyzed in 51 cases (24 HCCs and 27 HCAs). Results Hürthle cell neoplasms were predominant in females. Subjects ≥ 55 years represented 58% of the cases of HCCs and 53% of those of HCAs. Carcinomas were significantly larger (p < 0.001), and a tumor size ≥ 4 cm significantly increased the risk of malignancy (odds ratio 3.67). Other clinical, cytologic, and sonographic data were similar between HCCs and HCAs. Among the HCCs, the lesions were purely solid in 54.2%, hypoechoic in 37.5%, and had coarse calcifications in 12.5%, microcalcifications in 8.3%, irregular contours in 4.2%, and a taller-than-wide shape in 16.7%. Predominantly/exclusive intranodular vascularization was observed in 52.6%. Overall, 58% of the HCCs were classified as TI-RADS 4 or 5 compared with 48% of the HCAs. TI-RADS 4 or 5 had a specificity of only 51.8% and a positive likelihood ratio of 1.21. Conclusions Apart from the lesion size, no other preoperative feature adequately distinguished HCCs from HCAs. Sonographic characteristics raising suspicion for malignancy, which are mostly present in papillary carcinomas, were infrequent in HCCs. New tools must be developed to improve preoperative diagnosis and deferral of surgery in cases of adenomas.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: LILACS Asunto principal: Glándula Tiroides / Neoplasias de la Tiroides / Adenoma / Carcinoma Papilar Folicular / Ultrasonografía Doppler Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Banco de datos: LILACS Asunto principal: Glándula Tiroides / Neoplasias de la Tiroides / Adenoma / Carcinoma Papilar Folicular / Ultrasonografía Doppler Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Brasil