Sporadic inclusion body myositis: Diagnostic value of p62 immunostaining / Miositis con cuerpos de inclusión: valor de la inmunohistoquímica para p62 en su diagnóstico
Artículo
en Inglés
| IBECS (España) | ID: ibc-186950
Background and
objectives:
Sporadic inclusion body myositis (sIBM) diagnosis is frequently delayed or confused with another class of disorders, and misdiagnosis is common. Sometimes, we have problems diagnosing an sIBM in the early stages or predicting when a PM is going to become an sIBM. In this sense, we believe that p62 immunostaining could help clinicians. Case report We report the case of a 61-year-old patient with sIBM who six years earlier had been diagnosed with polymyositis (PM). After musclebiopsies analyses, we showed the natural history of sIBM by p62 expression.
Results:
When we looked for p62 aggregates retrospectively we could see small dotted p62 aggregates in the muscle fibres of the first musclebiopsy. Six years later, the patient presented with the typical clinical picture of sIBM, also the musclebiopsy was characteristic, with large p62 aggregates.
Conclusions:
Probably p62 immunostaining could help to distinguish PM patients that are going to become sIBM, but to date there has been no systematic study to clarify p62 utility in myositis
Cuando buscamos los agregados de p62 retrospectivamente pudimos ver pequeños agregados de p62 en las fibras musculares de la primera biopsia. Seis años más tarde, coincidiendo con el cuadro de presentación clínica, típico de MCI, la biopsia muscular resultó característica, mostrando grandes agregados de p62.
Conclusiones:
Probablemente la inmunotinción para p62 ayudaría a distinguir los pacientes con diagnóstico de PM que posteriormente van a convertirse en MCI, pero hasta ahora no hay un estudio sistemático para dilucidar la utilidad de p62 en miositis