Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio / Effects of low calcitonin doses on bone remodeling in postmenopausal women with high bone turnover rate
Rev. méd. Chile
; 128(4): 387-91, abr. 2000. tab
Article
en Es
| LILACS
| ID: lil-263707
Biblioteca responsable:
CL1.1
ABSTRACT
Background:
Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate.Aim:
To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover. Patients andmethods:
Forty one healthy women aged 56 ñ 6 years old, with a mean lapse after menopause of 7.6 ñ 6.5 years and with a high bone turnover rate, evidenced by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 ñ 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days.Results:
Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period.Conclusions:
Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women
Texto completo:
1
Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Calcitonina
/
Osteoporosis Posmenopáusica
/
Remodelación Ósea
/
Posmenopausia
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2000
Tipo del documento:
Article
/
Congress and conference
País de afiliación:
Chile