Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.
Nat Med
; 5(4): 399-404, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10202928
ABSTRACT
The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-cell surface. These results provide new insights into the mechanism of T-cell activation and evidence that CD8 function is exquisitely sensitive to disruption, an effect that might be exploited by molecular therapeutics.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T Citotóxicos
/
Antígenos CD8
/
Modelos Inmunológicos
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Reino Unido