Adrenomedullary response to caffeine in prepubertal and pubertal obese subjects.
Int J Obes Relat Metab Disord
; 23(9): 992-6, 1999 Sep.
Article
en En
| MEDLINE
| ID: mdl-10490807
ABSTRACT
OBJECTIVE:
To investigate whether blunted adrenomedullary responsiveness to stimuli is a primary feature of human obesity in childhood and adolescenceDESIGN:
Comparison of plasma catecholamine response to caffeine in obese and lean subjects before and after puberty onset.SUBJECTS:
Twelve lean prepubertal subjects (six males and six females), 15 prepubertal obese subjects (seven males and eight females), 12 pubertal lean subjects (six males and six females) and 24 pubertal obese subjects (12 males and 12 females) MEASUREMENTS Plasma levels of Luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17beta-estradiol and testosterone were used to validate Tanner score. Systolic and diastolic blood pressure, pulse rate and plasma catecholamines before and after caffeine administration (4 mg/kg of ideal body weight).RESULTS:
Caffeine administration significantly stimulated adrenaline release in all subjects studied. The incremental area of adrenaline response to caffeine, analysed by multiple comparison test, was lower in pubertal obese subjects with respect to other groups.CONCLUSIONS:
At variance with what is observed in adulthood obesity, prepubertal obese subjects show an intact adrenomedullary response to caffeine.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cafeína
/
Epinefrina
/
Pubertad
/
Médula Suprarrenal
/
Estimulantes del Sistema Nervioso Central
/
Obesidad
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Obes Relat Metab Disord
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia