Apparatus for studying in vitro drug release from medicated chewing gums.
Int J Pharm
; 189(1): 57-65, 1999 Oct 28.
Article
en En
| MEDLINE
| ID: mdl-10518685
ABSTRACT
An apparatus for in vitro drug release testing of medicated chewing gums has been developed and is described in detail. The effects on the drug release when varying critical instrumental settings such as the chewing stroke frequency, the distance between the chewing surfaces, the twisting movements of these surfaces and the temperature of the test medium have been thoroughly investigated. It has been shown that the drug release can be tuned to obtain suitable drug release profiles for a number of products Nicorette((R)) and Nicotinell((R)) (active substance nicotine), Travvell((R)) (dimenhydrinate), V6((R)) (xylitol) and an experimental formulation containing meclizine. The main usage of the present apparatus should be within quality control but the present study has also shown that it may be employed within development pharmaceutics since useful in vivo/in vitro relationships may be obtained due to the versatile settings of the critical instrumental parameters.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Goma de Mascar
/
Sistemas de Liberación de Medicamentos
Límite:
Humans
Idioma:
En
Revista:
Int J Pharm
Año:
1999
Tipo del documento:
Article
País de afiliación:
Suecia