Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C).
Brain Res Mol Brain Res
; 71(2): 349-53, 1999 Aug 25.
Article
en En
| MEDLINE
| ID: mdl-10521590
ABSTRACT
Prions are the causative agents of transmissible spongiform encephalopathies. The transmissible agent (PrP(Sc)) is an abnormal form of PrP(C), a normal neuronal protein. The physiological role of PrP(C) remains unclear. In the present report, we evaluated behavioral parameters in Prnp(0/0) mice devoid of PrP(C). Prnp(0/0) mice showed normal short- and long-term retention of a step-down inhibitory avoidance task and normal behavior in an elevated plus maze test of anxiety. During a 5-min exploration of an open field, Prnp(0/0) mice showed normal number of rearings, defecation, and latency to initiate locomotion, but a significant increase in the number of crossings. The results suggest that Prnp(0/0) mice show normal fear-motivated memory, anxiety and exploratory behavior, and a slight increase in locomotor activity during exploration of a novel environment.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Reacción de Prevención
/
Proteínas PrPC
/
Locomoción
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1999
Tipo del documento:
Article
País de afiliación:
Brasil