Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Science
; 288(5464): 306-13, 2000 Apr 14.
Article
en En
| MEDLINE
| ID: mdl-10764638
ABSTRACT
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Receptores de Droga
/
Nociceptores
/
Capsaicina
/
Neuronas Aferentes
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos