Global field power of auditory N1 correlates with impaired verbal-memory performance in human alcoholics.
Neurosci Lett
; 285(2): 131-4, 2000 May 12.
Article
en En
| MEDLINE
| ID: mdl-10793244
ABSTRACT
First weeks after alcohol withdrawal, associated with profound changes in neural transmission, constitute the critical period for relapse prevention and pharmacological intervention in alcoholism. Here, 20 male alcoholics with 1-6 weeks of abstinence and 20 age-matched healthy controls were studied using auditory event-related potentials (ERP), measured with a 32-channel electroencephalogram, and neuropsychological tests of auditory-verbal memory. Global field power maximum of ERP during 80-150 ms period after presentation of unattended tones (binaural 700 Hz pure tones, inter-stimulus interval 2.5 s) was significantly (P<0.01) larger in the alcoholics than controls. This effect, reflecting augmented N1 generation, significantly correlated (r=0.5) with impaired memory performance in the alcoholics. The profound change in pre-attentive auditory processing, predicting impaired memory performance, might reflect impaired cerebral inhibitory transmission in alcoholics.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Alcoholismo
/
Potenciales Evocados Auditivos
/
Memoria
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurosci Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Finlandia