Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer.
Eur J Cancer
; 36(12): 1552-7, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10930803
ABSTRACT
The fragile histidine triad (FHIT) gene is a candidate tumour suppressor gene in breast and other cancers. We investigated deletions within the FHIT gene in lobular breast cancer and found that 16% of cases showed loss of heterozygosity (LOH) within the gene. We compared LOH within FHIT in lobular and ductal breast tumours and found a significant association between LOH at FHIT and the ductal histological type (P<0.001). To determine whether genomic alteration of the FHIT gene in lobular breast cancer leads to Fhit inactivation we have assessed the level of Fhit expression by immunohistochemical detection and determined that 27% (15 of 55) consecutive sporadic lobular tumours showed negative or reduced Fhit expression. A significant association was found between LOH at the FHIT gene and reduced Fhit expression in lobular and ductal tumours (P=0.025 and P=0.001, respectively). Thus, genetic alterations within the FHIT gene, leading to loss of Fhit protein, may play an important role in the carcinogenesis of a significant number of sporadic lobular breast cancers, even though the apparent frequency of genomic alterations within the gene is lower than in ductal breast cancer.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Proteínas
/
Carcinoma Lobular
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Carcinoma Ductal de Mama
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Ácido Anhídrido Hidrolasas
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Pérdida de Heterocigocidad
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Proteínas de Neoplasias
Límite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Cancer
Año:
2000
Tipo del documento:
Article
País de afiliación:
Islandia