Calcium sensitivity of glutamate release in a calyx-type terminal.
Science
; 289(5481): 953-7, 2000 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-10937999
ABSTRACT
Synaptic efficacy critically depends on the presynaptic intracellular calcium concentration ([Ca2+]i). We measured the calcium sensitivity of glutamate release in a rat auditory brainstem synapse by laser photolysis of caged calcium. A rise in [Ca2+]i to 1 micromolar readily evoked release. An increase to >30 micromolar depleted the releasable vesicle pool in <0.5 millisecond. A comparison with action potential-evoked release suggested that a brief increase of [Ca2+]i to approximately 10 micromolar would be sufficient to reproduce the physiological release pattern. Thus, the calcium sensitivity of release at this synapse is high, and the distinction between phasic and delayed release is less pronounced than previously thought.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Tronco Encefálico
/
Calcio
/
Ácido Glutámico
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania