The role of calcium and fluoride in osteoporosis in rhesus monkeys.
Invest Radiol
; 10(3): 263-8, 1975.
Article
en En
| MEDLINE
| ID: mdl-1132953
ABSTRACT
Twenty-two female Rhesus monkeys were fed purified diets varying in calcium and fluoride content for five years and studied, using radiographic, photon absorptiometric and histologic techniques. The results suggested that 1) the addition of fluoride (50 ppm) to a diet containing 1 per cent calcium resulted in a reduction in bone growth rate and resorption, without affecting bone size or density nor resulting in fluorosis; 2) a diet containing 0.15 per cent calcium resulted in osteoporosis due to an increase in bone resorption; and 3) fluoride added to a similar low calcium diet prevented osteroporosis by reducing bone growth rate and resorption resulting in bones with normal density, but at the same time fluoride interfered with mineralization of osteoid leading to osteomalacia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Calcio
/
Fluoruros
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Invest Radiol
Año:
1975
Tipo del documento:
Article