[Urokinase stimulates whereas tissue plasminogen activator attenuates blood vessel stenosis]. / Urokinaza stimuliruet, a tkanevoi aktivator plazminogena podavliaet razvitie stenoza krovenosnykh sosudov.
Ross Fiziol Zh Im I M Sechenova
; 87(5): 584-93, 2001 May.
Article
en Ru
| MEDLINE
| ID: mdl-11452792
ABSTRACT
Periadventitial application of the urokinase-plasminogen activator (uPA) in pluronic gel to an injured artery stimulated the neointima and neoadventitia formation as well as cell migration and proliferation in vivo. In contrast, the tissue-type plasminogen activator (tPA) reduced the number of neointimal smooth muscle cells and neointimal area and attenuated the lumen stenosis after a balloon catheter injury of the rat carotid artery. This ability to stimulate the neointima and neoadbentitia formation was found to be quite specific for the uPA. The findings suggest that this uPA property provides a specific functional target for attenuating growth of the damage.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activador de Plasminógeno de Tipo Uroquinasa
/
Estenosis Carotídea
/
Activador de Tejido Plasminógeno
/
Arteria Carótida Común
Límite:
Animals
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Asunto de la revista:
FISIOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Rusia