Fluorescence in situ hybridization analysis of peripheral blood cells in Pearson marrow-pancreas syndrome.

Yanagihara, I; Inui, K; Yanagihara, K; Park, Y D; Tanaka, J; Ozono, K; Okada, S; Kurahashi, H

Yanagihara, I; Inui, K; Yanagihara, K; Park, Y D; Tanaka, J; Ozono, K; Okada, S; Kurahashi, H.

Afiliación

Yanagihara I; Department of Environmental Medicine, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi City, Osaka, Japan.

J Pediatr ; 139(3): 452-5, 2001 Sep.

Article en En | MEDLINE | ID: mdl-11562629

RESUMEN

We used a dual-color fluorescence in situ hybridization technique to estimate deleted mitochondrial DNA at a single-cell level and determine any correlation with the disease progression in lymphocytes from patients with Pearson marrow-pancreas syndrome. The method demonstrated a shift in heteroplasmy, paralleling the hematologic improvement.

Asunto(s)

Anemia Sideroblástica/genética; ADN Mitocondrial/sangre; Hibridación Fluorescente in Situ/métodos; Enfermedades Pancreáticas/genética; Anemia Sideroblástica/sangre; Femenino; Células Madre Hematopoyéticas/patología; Humanos; Lactante; Linfocitos; Enfermedades Pancreáticas/sangre; Síndrome

Buscar en Google

Imprimir

XML

PubMed Links

Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Pancreáticas / ADN Mitocondrial / Hibridación Fluorescente in Situ / Anemia Sideroblástica Límite: Female / Humans / Infant Idioma: En Revista: J Pediatr Año: 2001 Tipo del documento: Article País de afiliación: Japón

Buscar en Google

Imprimir

XML

PubMed Links