Preparation of a cimetidine ion-selective electrode and its application to pharmaceutical analysis.
J Pharm Biomed Anal
; 27(6): 867-72, 2002 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-11836050
ABSTRACT
A novel cimetidine ion-selective electrode is prepared, characterized and used in pharmaceutical analysis. The electrode incorporates PVC-membrane with cimetidine-phospohotungstate ion pair complex. The electrode exhibits a Nernstian response for cimetidine in the concentration range 1.0 x 10(-5)-1.0 x 10(-2) M with a slope of 58+/-1 mV per decade. The limit of detection is 5.0 x 10(-6) M. The electrode displays a good selectivity for cimetidine with respect to a number of common foreign inorganic and organic species. It can be used in the pH range 3.0-5.5. The membrane sensor was successfully applied to the determination of cimetidine in its tablets as well as its recovery from a urine sample.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cimetidina
/
Antiulcerosos
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2002
Tipo del documento:
Article
País de afiliación:
Irán