Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.
Pharmacol Ther
; 92(2-3): 109-22, 2001.
Article
en En
| MEDLINE
| ID: mdl-11916532
When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential before approving it for clinical practice. In this review, identified predisposing factors have been related to specific electrophysiological parameters, allowing quantification of their contribution to Torsade de Pointes arrhythmias. In addition, arrhythmogenic mechanisms involved in the initiation and perpetuation of drug-induced Torsade de Pointes are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Torsades de Pointes
/
Muerte Súbita Cardíaca
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pharmacol Ther
Año:
2001
Tipo del documento:
Article
País de afiliación:
Países Bajos