Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease.
Neurobiol Dis
; 10(1): 28-32, 2002 Jun.
Article
en En
| MEDLINE
| ID: mdl-12079401
ABSTRACT
In the present study, we tried to clarify the potentially protective role of Bcl-x(L), an anti-apoptotic member of the Bcl-2 family of proteins, in Parkinson's disease (PD). Using in situ hybridization on human postmortem mesencephalon sections, we show that in PD patients Bcl-x(L) mRNA expression per dopaminergic neuron was almost double that of controls. We also show that, ultrastructurally, this effect may be mediated by a redistribution of Bcl-x(L) from the cytosol to the outer mitochondrial membrane.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Apoptosis
/
Proteínas Proto-Oncogénicas c-bcl-2
Límite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Neurobiol Dis
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia