Loss of capacity to elevate plasma cortisol in rainbow trout (Oncorhynchus mykiss) treated with a single injection of o,p'-dichlorodiphenyldichloroethane.
Environ Toxicol Chem
; 21(8): 1753-6, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12152779
ABSTRACT
The organochlorine o,p'- dichlorodiphenyldichloroethane (o,p'-DDD) is a metabolite of dichlorodiphenyltrichloroethane (DDT), known for its adrenolytic actions in birds and mammals. The effects of o,p'-DDD on the cortisol stress response were investigated in rainbow trout, Oncorhynchus mykiss, in a dose-response study in vivo. A dose-dependent decrease in plasma cortisol levels was observed on days 7 and 14 after a single i.p. injection of o,p'-DDD. Treatment with o,p'-DDD had no effect on weight gain, hematocrit, and gonado- or hepatosomatic index but decreased liver glycogen reserves. The results indicate that o,p'-DDD is an adrenotoxic compound in rainbow trout and that its effects can be detected even 14 d postinjection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hidrocortisona
/
Oncorhynchus mykiss
/
Glándulas Suprarrenales
/
Antineoplásicos Hormonales
/
Mitotano
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Chem
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá