The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded.
FEBS Lett
; 527(1-3): 303-8, 2002 Sep 11.
Article
en En
| MEDLINE
| ID: mdl-12220679
ABSTRACT
The proteins securin and cyclin B are destroyed in mitosis by the ubiquitin/proteasome system. This destruction is important to mitotic progression. The N-terminal regions of these proteins contain the sequence features recognized by the ubiquitination system. We have demonstrated using circular dichroism and 1-D and 2-D nuclear magnetic resonance that these rather substantial regions are natively unfolded. Based on these findings, we propose a model that helps to explain previously enigmatic observations.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Fúngicas
/
Proteínas Nucleares
/
Proteínas de Ciclo Celular
/
Ciclina B
/
Proteínas de Saccharomyces cerevisiae
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos