Different effects of endotoxin versus mite and cat allergen exposure on T-cell differentiation in infants.
J Allergy Clin Immunol
; 110(4): 634-40, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12373273
ABSTRACT
BACKGROUND:
Early exposure to bacterial endotoxin has been proposed to protect against allergy development in children. Whether endotoxin is able to direct T-cell differentiation into a predominance of type 1 immunity is still unresolved.OBJECTIVE:
We sought to compare the effects of endotoxin and mite and cat allergens on T-cell differentiation in infants.METHODS:
In a random population sample of 135 2-year-old children of an ongoing birth-cohort study, peripheral blood CD4+ and CD8+ T-cell subsets were defined by the expression of the chemokine receptors CCR5 and CCR3 as surrogate markers for type 1 and type 2 T cells, respectively. Endotoxin and mite and cat allergens were measured in house dust collected from the mother's mattress at the child's age of 3 months to assess early exposure.RESULTS:
In the CD4+ T-cell subset, endotoxin levels were positively associated with high proportions of type 1 CCR5+ cells (odds ratio for fourth exposure quartile [OR(Q4)], 7.68; 95% CI, 1.35-43.75), whereas cat allergen levels were associated with increased proportions of type 2 CCR3+ cells (OR(Q4), 4.07; 95% CI, 1.05-15.85). In contrast to endotoxin, allergen levels were associated with CD8+ T cells, showing an inverse relationship between mite allergen concentrations and high proportions of CCR5+ or CCR3+ cells (CCR5+ cells OR(Q4), 0.14; 95% CI, 0.03-0.74; CCR3+ cells OR(Q4), 0.16; 95% CI, 0.03-0.89) and a positive association of cat allergen levels with increased proportions of CCR5+ cells (OR(Q4), 9.24, 95% CI, 1.61-53.10), as well as CCR3+ cells (OR(Q3), 6.64; 95% CI, 1.21-36.51).CONCLUSION:
Our results indicate that endotoxin has the potential to promote the development of type 1 CD4+ T cells, whereas mite and cat allergens primarily modify the proportion of CD8+ cells of both types.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Alérgenos
/
Linfocitos T
/
Gatos
/
Endotoxinas
/
Ácaros
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania