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A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript.
Imamura, T; Morimoto, A; Ikushima, S; Kakazu, N; Hada, S; Tabata, Y; Yagi, T; Inaba, T; Hibi, S; Sugimoto, T; Imashuku, S.
Afiliación
  • Imamura T; Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Leukemia ; 16(11): 2302-8, 2002 Nov.
Article en En | MEDLINE | ID: mdl-12399976
Infant acute lymphoblastic leukemia (ALL) is characterized by the presence of the proB phenotype (CD10(-)/CD19(+)), poor prognosis and frequent rearrangement of the mixed lineage leukemia (MLL) gene. The most frequent rearrangement is t(4;11)(q21;q23), the role of whose product, the MLL-AF4 fusion transcript, has been extensively studied in leukemogenesis. In a cell line of infant leukemia with MLL rearrangement denoted KP-L-RY, panhandle PCR amplification of cDNA revealed the presence of a fusion transcript, MLL-AF5q31, indicating that AF5q31 is also a partner gene of MLL. In this fusion transcript the MLL exon 6 is fused in frame to the 5' side of the putative transactivation domain of AF5q31. The AF5q31 protein is a member of the AF4/LAF4/FMR2-related family of proteins, which have been suggested to play a role in hematopoietic cell growth and differentiation. The MLL-AF5q31 fusion transcript, although probably rare, appears to be associated with the pathogenesis of infant ALL like MLL-AF4. Co-expression of HoxA9 and Meis1 genes in the KP-L-RY cell line indicated possible functional similarity between MLL-AF4 and MLL-AF5q31. Further understanding of the function of AF5q31 as well as the specific leukemogenic mechanism of MLL-AF5q31 awaits future studies.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Proteínas de Fusión Oncogénica / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Male Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2002 Tipo del documento: Article País de afiliación: Japón
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Proteínas de Fusión Oncogénica / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans / Infant / Male Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2002 Tipo del documento: Article País de afiliación: Japón