Recombinant follicle-stimulating hormone versus human menopausal gonadotropin in the late follicular phase during ovarian hyperstimulation for in vitro fertilization.
Fertil Steril
; 78(5): 1049-54, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12413992
ABSTRACT
OBJECTIVE:
To study the effect of exogenous LH in the late follicular phase on ongoing pregnancies and at the different stages of IVF-ET (stimulation, fertilization, and implantation) in patients with low endogenous LH.DESIGN:
Retrospective cohort study with modeling of the different phases of IVF-ET.SETTING:
IVF center of the teaching hospital in Bordeaux, France. PATIENT(S) Women undergoing IVF and ICSI treatment. INTERVENTION(S) One group received recombinant FSH alone (FSH group) and the other received recombinant FSH and hMG in the late follicular phase (i.e., when the largest follicle reached 14 mm) (FSH/hMG group). MAIN OUTCOME MEASURE(S) Ongoing pregnancy, number of oocytes, and number of embryos. RESULT(S) The FSH/hMG group had a higher probability of having at least one oocyte (odds ratio [OR] = 2.75 [1.11-6.80]), of having at least one embryo after oocyte retrieval (OR = 2.84 [1.33-6.07]), and of ongoing pregnancy after ET (OR = 2.04 [0.83-5.01]), and globally had a higher probability of ongoing pregnancy (OR = 2.83 [1.19-6.71]). CONCLUSION(S) In ovarian hyperstimulation for IVF-ET, LH supplementation in the late follicular phase of women with low endogenous LH is beneficial for ongoing pregnancy by increasing the rate of success of all stages of the treatment.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fertilización In Vitro
/
Fase Folicular
/
Hormona Folículo Estimulante
/
Menotropinas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Año:
2002
Tipo del documento:
Article
País de afiliación:
Francia