Mechanobiology of the intervertebral disc.
Biochem Soc Trans
; 30(Pt 6): 853-8, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12440932
ABSTRACT
Intervertebral disc degeneration has been linked in humans to extreme spinal loading regimens. However, mechanisms by which spinal force influences disc cellularity, morphology and consequently biomechanical function are unclear. To gain insight into mechanobiological interactions within the disc, we developed an in vivo murine tail-compression model. Results from this model demonstrate how deviations in spinal stress induce a cycle of altered cell function and morphology as the disc remodels to a new homoeostatic configuration.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Disco Intervertebral
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos