Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones.
Org Lett
; 4(22): 3811-4, 2002 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-12599465
ABSTRACT
[formula see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tolerates a wide range of functional groups.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Epotilonas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Suiza