Simultaneous pancreas-kidney transplantation in patients with antiphospholipid syndrome.
Transplantation
; 75(4): 562-3, 2003 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-12605129
ABSTRACT
BACKGROUND:
Graft thrombosis is one of the main reasons of graft loss following simultaneous pancreas-kidney transplantation (SPK). Although antiphospholipid syndrome (APLS) is known as a high risk for graft thrombosis in kidney transplants alone, little is known about APLS in SPK.METHODS:
Between September 2000 and December 2001, 45 SPK were performed. The treatment and clinical course of 2 patients with APLS is presented.RESULTS:
In one patient, APLS was known before transplantation. After SPK, she was treated by systemic heparin followed by coumarin. Both grafts are doing well 5 months posttransplant. The second patient underwent SPK without knowledge of APLS. The patient developed a deep vein thrombosis 5 weeks posttransplant. Hypercoagulability screening revealed APLS. Treatment consisted of systemic anticoagulation. Grafts were not affected.CONCLUSION:
SPK can successfully be performed in APLS patients if anticoagulation is performed consistently. To reduce the risk of graft thrombosis, a pretransplant screening for APLS would probably be of benefit.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Trasplante de Páncreas
/
Síndrome Antifosfolípido
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Transplantation
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania