Autologous blood cell transplantation in multiple myeloma: impact of CD34+ cell selection with long follow-up.
J Hematother Stem Cell Res
; 12(1): 63-70, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12662437
ABSTRACT
Positive CD34(+) selection to purge blood cell harvests is one way to attempt to reduce the high relapse risk after high-dose chemotherapy (HDT) supported by autologous blood cell transplantation (ABCT) in patients with multiple myeloma (MM). Until recently, however, the impact of CD34(+) selection, if any, on long-term clinical outcome in MM has remained obscure. We have analyzed engraftment kinetics, response to HDT, progression-free survival (PFS), and overall survival (OS) for 64 consecutive MM patients who have been treated with up-front HDT plus ABCT at our institution between 1993 and 1998. Nonrandomized comparisons were made between transplants with unselected (39 patients) and CD34(+)-selected (25 patients) grafts. The engraftment kinetics, need of blood product support, discharge time from hospital, and response to HDT were similar for both unselected and selected transplants. The median PFS was also similar (26 and 30 months, respectively) for the both groups. With a median follow-up time for the survivors of 67.5 months, the median OS (78 and 75 months, respectively) did not differ between transplants with unselected and selected grafts. In conclusion, this nonrandomized study suggests that positive CD34(+) selection has no beneficial impact on long-term outcome of patients with MM.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transfusión de Sangre Autóloga
/
Antígenos CD34
/
Mieloma Múltiple
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Hematother Stem Cell Res
Asunto de la revista:
HEMATOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Finlandia