Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
Science
; 299(5615): 2071-4, 2003 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-12663927
ABSTRACT
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genoma Bacteriano
/
Enterococcus faecalis
/
Análisis de Secuencia de ADN
/
Secuencias Repetitivas Esparcidas
/
Resistencia a la Vancomicina
/
Evolución Biológica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos