Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons.
Neuron
; 9(2): 285-94, 1992 Aug.
Article
en En
| MEDLINE
| ID: mdl-1323312
ABSTRACT
Platelet-activating factor (PAF), an alkylether phospholipid, is produced in the brain when it is subjected to various stimuli. Using a Xenopus oocyte expression system, we obtained evidence for functional PAF receptor mRNA expression in rat brain. The presence of the PAF receptor was confirmed and shown to be quite ubiquitous in the CNS by RNA blot and radioligand binding studies. To investigate the neuronal functions of PAF, intracellular Ca2+ increase elicited by nanomolar PAF application was analyzed in cultured rat hippocampal cells. Fractions of NMDA-responsive cells and non-NMDA-responsive cells were shown to respond to PAF, suggesting a potential role for PAF in the Ca2+ signaling pathway in the hippocampus.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Factor de Activación Plaquetaria
/
Glicoproteínas de Membrana Plaquetaria
/
Calcio
/
Receptores de Superficie Celular
/
Receptores Acoplados a Proteínas G
/
Hipocampo
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Japón