Control of pepsin secretion by regulatory peptides in the rat stomach: comparison with acid secretion.
Peptides
; 13(2): 233-9, 1992.
Article
en En
| MEDLINE
| ID: mdl-1409002
ABSTRACT
Previous studies of the control of pepsin secretion by neurohumoral agents showed some discrepancies between in vitro (isolated cells) and in vivo experiments. In the present work, the effects on pepsin secretion of CCK, pentagastrin, secretin, VIP, neurotensin, histamine, and methacholine were reinvestigated in conscious gastric fistula rats, in comparison to acid secretion. ED50's and doses inducing maximal responses were measured to directly compare the potency and efficacy of these substances. Methacholine was the most efficient (maximal response = 4.5 x basal level, ED50 = 1.3 mumol/kg.h) and CCK the most potent (ED50 = 1.9 nmol/kg.h) stimulant, whereas secretin was a potent (ED50 regulators of pepsin secretion in the rat. Pentagastrin and histamine did not stimulate pepsin output, as found by others with isolated chief cells in vitro. Neurotensin and large doses of VIP marginally inhibited pepsin secretion.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fármacos Gastrointestinales
/
Pepsina A
/
Ácido Gástrico
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia