Inference of Euler angles for single particle analysis by using Genetic Algorithms.
Genome Inform
; 13: 133-42, 2002.
Article
en En
| MEDLINE
| ID: mdl-14571382
ABSTRACT
Single particle analysis is one of the methods for structural studies of protein and macromolecules developed in image analysis on electron microscopy. Reconstructing 3D structure from microscope images is not an easy analysis because of the low resolution of images and lack of the directional information of images in 3D structure. To improve the resolution, different projections are aligned, classified and averaged. Inferring the orientations of these images is so difficult that the task of reconstructing 3D structures depends upon the experience of researchers. But recently, a method to reconstruct 3D structures is automatically devised. In this paper, we propose a new method for determining Euler angles of projections by applying Genetic Algorithms (i.e., GAs). We empirically show that the proposed approach has improved the previous one in terms of computational time and acquired precision.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Interpretación Estadística de Datos
/
Estructura Terciaria de Proteína
/
Biología Computacional
Idioma:
En
Revista:
Genome Inform
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón