Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery.
Brain Res
; 995(1): 145-9, 2004 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-14644480
ABSTRACT
In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Hemorragia Cerebral
/
Isquemia Encefálica
/
Circulación Cerebrovascular
/
Arteria Cerebral Media
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2004
Tipo del documento:
Article
País de afiliación:
Rusia