Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism.
Redox Rep
; 8(5): 246-50, 2003.
Article
en En
| MEDLINE
| ID: mdl-14962358
ABSTRACT
Over the last few years, an increasing number of different functions have been ascribed to small redox-active proteins like thioredoxins (Trx) and glutaredoxins (Grx). These functions include redox regulation of transcription and translation, antioxidant defence, involvement in protein folding and cellular signalling, and reduction of ribonucleotide reductase. In the malarial parasite Plasmodium falciparum, a classical Trx and a typical Grx have been described as well as a number of Trx- and Grx-like proteins including monothiol glutaredoxins. Furthermore, plasmoredoxin, a redox-active protein related to Trx, has been characterized; plasmoredoxin is unique for malarial parasites, therefore having great potential as diagnostic tool. In this minireview, we summarize the current knowledge on members of the thioredoxin superfamily and their function in the malarial parasite P. falciparum.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Plasmodium falciparum
/
Tiorredoxinas
/
Proteínas
/
Proteínas Protozoarias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Redox Rep
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania