The utility of an anti-fos ribozyme in reversing cisplatin resistance in human carcinomas.
Adv Enzyme Regul
; 32: 195-209, 1992.
Article
en En
| MEDLINE
| ID: mdl-1496917
ABSTRACT
The results presented here demonstrate that expression of a fos ribozyme limits Fos protein synthesis and enhances sensitivity of A2780DDP cells to antineoplastic agents, including cisplatin. Moreover, the reversal of this resistance is associated with down-regulation of dTMP synthase, DNA polymerase beta, topoisomerase I and hMTII-A, genes previously linked to DNA synthesis and repair. Thus these studies further implicate the role of the c-fos gene in DNA synthesis through modulation of expression of dTMP syntase, DNA polymerase beta and topoisomerase I. Finally, the use of ribozymes to circumvent drug resistance suggests their potential utility as agents to inhibit tumor cell growth.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Regulación Neoplásica de la Expresión Génica
/
ARN Catalítico
/
Cisplatino
/
Proteínas Proto-Oncogénicas c-fos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Adv Enzyme Regul
Año:
1992
Tipo del documento:
Article