Myc: a weapon of mass destruction.
Cell
; 117(2): 153-6, 2004 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-15084254
ABSTRACT
Growth and proliferation potentiated by deregulated myc oncogene expression is balanced by myc-induced apoptosis. Abrogation of this apoptotic pathway in Myc overexpressing cells leads to cancer progression. Recent work has shown that cell clones in the Drosophila wing disc with higher dMyc expression levels act as supercompetitors to potentiate the programmed death of surrounding normal cells. Yet another paper identifies dE2F1 as a critical component of pathways that normally restrict the ability of growth perturbing genes like dMyc to cause organ overgrowth.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Genes myc
/
Proteínas Proto-Oncogénicas c-myc
/
Apoptosis
/
Proteínas de Ciclo Celular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos